Acetarsol in the management of mesalazine refractory ulcerative proctitis: a tertiary-level care experience

Argyriou, Konstantinos; Samuel, Sunil; Moran, Gordon W.

Abstract

© 2018 Wolters Kluwer Health, Inc. All rights reserved. Background Mesalazine-refractory ulcerative proctitis is common, with a significant proportion of the patients requiring escalation to immunomodulators or biological therapy. Three small preliminary cohort studies suggested good clinical efficacy for the organic arsenic derivative acetarsol in the management of proctitis. Our aim was to describe our experience on the use of acetarsol in proctitis and to review all existing evidence on its safety and efficacy.Patients and methodsWe retrospectively reviewed clinical records of all ulcerative colitis patients exposed to acetarsol at Nottingham University Hospitals since 2012. Clinical response was determined basing on physicians' global assessments and patients' improvement over the baseline (reduction in stool frequency and rectal bleeding). Clinical remission was defined as total resolution of symptoms including bleeding cessation. Serum arsenic, C-reactive protein and faecal calprotectin levels reviewed when available. Nonparametric analysis performed.ResultsTwenty-eight (16 males) patients with median (range) age 39 (35) and 9 (19) years disease duration received acetarsol suppositories for proctitis. All had failed mesalazine or corticosteroid topical therapy, with 50% having additionally failed immunomodulators. Median treatment duration was 70 (64) days. 16/28 were prescribed acetarsol more than once. 67.9% achieved clinical response and 46.4% clinical remission. 32.1% required treatment escalation to steroids, thiopurines or antitumour necrosis factor agents. 6/28 patients stopped acetarsol due to side effects.ConclusionAcetarsol could be an effective and safe option in the management of refractory proctitis. A definitive trial with long-term safety follow-up is required to investigate the efficacy and safety of this promising drug.

Citation

Argyriou, K., Samuel, S., & Moran, G. W. (2019). Acetarsol in the management of mesalazine refractory ulcerative proctitis: a tertiary-level care experience. European Journal of Gastroenterology and Hepatology, 31(2), 183-186. https://doi.org/10.1097/MEG.0000000000001326

• Journal Article Type: Article
• Acceptance Date: Nov 14, 2018
• Online Publication Date: Nov 29, 2018
• Publication Date: Feb 1, 2019
• Deposit Date: Nov 27, 2018
• Publicly Available Date: Nov 30, 2019
• Journal: European Journal of Gastroenterology and Hepatology
• Print ISSN: 0954-691X
• Electronic ISSN: 1473-5687
• Publisher: Lippincott, Williams & Wilkins
• Peer Reviewed: Peer Reviewed
• Volume: 31
• Issue: 2
• Pages: 183-186
• DOI: https://doi.org/10.1097/MEG.0000000000001326
• Keywords: Acetarsol, Ulcerative proctitis, Refractory proctitis, Ulcerative colitis
• Public URL: https://nottingham-repository.worktribe.com/output/1309820
• Publisher URL: https://journals.lww.com/eurojgh/Abstract/2019/02000/Acetarsol_in_the_management_of.6.aspx
• Contract Date: Nov 27, 2018