All Outputs (4605)

Synthetic glycopolymers as modulators of protein aggregation: influence of chemical composition, topology and concentration (2018)
Journal Article

Novel drug excipients are required to achieve stable formulations of protein drug candidates. Synthetic glycopolymers have been shown in some cases to improve protein formulation stability, although their structure function relationship remains unkno... Read More about Synthetic glycopolymers as modulators of protein aggregation: influence of chemical composition, topology and concentration.

The use of visual schedules and work systems to increase the on-task behaviour of students on the autism spectrum in mainstream classrooms (2018)
Journal Article

Apparent differences in executive function can lead to challenges for students on the autism spectrum in mainstream settings. Difficulties with staying on-task and transitioning between tasks or task elements can interfere with students’ participatio... Read More about The use of visual schedules and work systems to increase the on-task behaviour of students on the autism spectrum in mainstream classrooms.

Five years of monitoring for the emergence of oseltamivir resistance in patients with influenza A infections in the Influenza Resistance Information Study (IRIS) (2018)
Journal Article

Duration and magnitude of postoperative risk of venous thromboembolism after planned inguinal hernia repair in men: a population-based cohort study (2018)
Journal Article

Purpose Little is known regarding the magnitude and timing of the risk of VTE following inguinal hernia surgery. We aimed to determine the absolute and relative rates of venous thromboembolism (VTE) following planned inguinal hernia repair. Metho... Read More about Duration and magnitude of postoperative risk of venous thromboembolism after planned inguinal hernia repair in men: a population-based cohort study.

Characteristics and needs of long-stay forensic psychiatric inpatients: a rapid review of the literature (2018)
Journal Article

This rapid review summarises currently available information on the definition, prevalence, characteristics and needs of long-stay patients within forensic psychiatric settings. Sixty nine documents from 14 countries were identified. Reports on what... Read More about Characteristics and needs of long-stay forensic psychiatric inpatients: a rapid review of the literature.

A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink (2018)
Journal Article

Purpose: The CirCom score has been developed from Danish data as a specific measure of comorbidity for cirrhosis to predict all-cause mortality. We compared its performance with the Charlson Comorbidity Index (CCI) in an English cirrhosis population.... Read More about A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink.

Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF) (2018)
Journal Article

Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its translational regulation by HIF-1?. The rol... Read More about Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF).

Human Trafficking on the Global Periphery: A Terrible Spectacle (2018)
Book Chapter

In mainstream criminological research, human trafficking has been constructed as a form of transnational organized crime, with the institutionalization of this approach reflected in international criminal law. Based on ethnographic research and secon... Read More about Human Trafficking on the Global Periphery: A Terrible Spectacle.

Estimation and analysis of multi-GNSS differential code biases using a hardware signal simulator (2018)
Journal Article

In ionospheric modeling, the differential code biases (DCBs) are a non-negligible error source, which are routinely estimated by the different analysis centers of the International GNSS Service (IGS) as a by-product of their global ionospheric analys... Read More about Estimation and analysis of multi-GNSS differential code biases using a hardware signal simulator.

Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells (2018)
Journal Article

The efficacy of temozolomide (TMZ) treatment for cancers is currently limited by inherent or the development of resistance, particularly, but not exclusively, due to the expression of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT... Read More about Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells.

Exploring the advantages of multiband fMRI with simultaneous EEG to investigate coupling between gamma frequency neural activity and the BOLD response in humans (2018)
Journal Article

We established an optimal combination of EEG recording during sparse multiband (MB) fMRI that preserves high resolution, whole brain fMRI coverage whilst enabling broad-band EEG recordings which are uncorrupted by MRI gradient artefacts (GAs). We fir... Read More about Exploring the advantages of multiband fMRI with simultaneous EEG to investigate coupling between gamma frequency neural activity and the BOLD response in humans.

On Ehrhart Polynomials of Lattice Triangles (2018)
Journal Article

The Ehrhart polynomial of a lattice polygon PP is completely determined by the pair (b(P),i(P))(b(P),i(P)) where b(P)b(P) equals the number of lattice points on the boundary and i(P)i(P) equals the number of interior lattice points. All possible pair... Read More about On Ehrhart Polynomials of Lattice Triangles.

Pharmacologic evidence for a putative conserved allosteric site on opioid receptors (2018)
Journal Article

Allosteric modulators of G protein-coupled receptors, including opioid receptors, have been proposed as possible therapeutic agents with enhanced selectivity. BMS-986122 is a positive allosteric modulator (PAM) of the μ-opioid receptor (μ-OR). BMS-98... Read More about Pharmacologic evidence for a putative conserved allosteric site on opioid receptors.

Informality in the New Urban Agenda: from the aspirational policies of integration to a politics of constructive engagement (2018)
Journal Article

Numerical and Experimental Investigations of Reinforced Masonry Structures Across Multiple Scales (2018)
Book Chapter

© Springer International Publishing AG 2018. This review chapter outlines the outcomes of a combined experimental-numerical investigation on the retrofitting of masonry structures by means of polymeric textile reinforcement. Masonry systems comprise... Read More about Numerical and Experimental Investigations of Reinforced Masonry Structures Across Multiple Scales.

Large neighbourhood search with adaptive guided ejection search for the pickup and delivery problem with time windows (2018)
Journal Article

© 2018, The Author(s). An effective and fast hybrid metaheuristic is proposed for solving the pickup and delivery problem with time windows. The proposed approach combines local search, large neighbourhood search and guided ejection search in a novel... Read More about Large neighbourhood search with adaptive guided ejection search for the pickup and delivery problem with time windows.

Growing up in a megalopolis: environmental effects on galaxy evolution in a supercluster at z?0.65 in UKIDSS UDS (2018)
Journal Article

We present a large-scale galaxy structure Cl J021734-0513 at z ∼ 0.65 discovered in the UKIDSS UDS field, made of ∼ 20 galaxy groups and clusters, spreading over 10 Mpc. We report on a VLT/VIMOS spectroscopic follow-up program that, combined with pas... Read More about Growing up in a megalopolis: environmental effects on galaxy evolution in a supercluster at z?0.65 in UKIDSS UDS.

Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging (2018)
Journal Article

The short shelf-life of water-soluble quantum dots (QDs) due to colloidal instability represents a major drawback to their exploitation. This work examines the colloidal stability of PbS nanoparticles capped with dihydrolipoic acid–polyethylene glyco... Read More about Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging.

Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24–48 h after exercise in young and old humans (2018)
Journal Article

The molecular and metabolic mechanisms underlying the increase in insulin sensitivity (i.e. increased insulin-stimulated skeletal muscle glucose uptake, phosphorylation and storage as glycogen) observed from 12 to 48 h following a single bout of exer... Read More about Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24–48 h after exercise in young and old humans.

Quantitative outcomes of a One Health approach to study global health challenges (2018)
Journal Article

Having gained momentum in the last decade, the One Health initiative promotes a holistic approach to address complex global health issues. Before recommending its adoption to stakeholders, however, it is paramount to first compile quantitative eviden... Read More about Quantitative outcomes of a One Health approach to study global health challenges.