Exploring the advantages of multiband fMRI with simultaneous EEG to investigate coupling between gamma frequency neural activity and the BOLD response in humans

Uji, Makoto; Wilson, Ross; Francis, Susan T.; Mullinger, Karen J.; Mayhew, Stephen D.

Abstract

We established an optimal combination of EEG recording during sparse multiband (MB) fMRI that preserves high resolution, whole brain fMRI coverage whilst enabling broad-band EEG recordings which are uncorrupted by MRI gradient artefacts (GAs). We firstly determined the safety of simultaneous EEG recording during MB fMRI. Application of MB factor = 4 produced <1°C peak heating of electrode/hardware during 20-minutes of GE–EPI data acquisition. However, higher SAR sequences require specific safety testing, with greater heating observed using PCASL with MB factor =4. Heating was greatest in the electrocardiogram channel, likely due to it possessing longest lead length. We investigated the effect of MB factoron the temporal signal to noise ratio for a range of GE-EPI sequences (varying MB factor and temporal interval between slice acquisitions). We found that, for our experimental purpose, the optimal acquisition was achieved with MB factor=3, 3mm isotropic voxels and 33 slices providing whole head coverage. This sequence afforded a 2.25s duration quiet period (without GAs) in every 3s TR. Using this sequence we demonstrated the ability to record gamma frequency (55-80Hz) EEG oscillations, in response to right index finger abduction, that are usually obscured by Gas during continuous fMRI data acquisition. In this novel application of EEG - MB fMRI to a motor task we observed a positive correlation between gamma and BOLD responses in bilateral motor regions. These findings support and extend previous work regarding coupling between neural and haemodynamic measures of brain activity in humans and showcase the utility of EEG-MB fMRI for future investigations.

Citation

Uji, M., Wilson, R., Francis, S. T., Mullinger, K. J., & Mayhew, S. D. (2018). Exploring the advantages of multiband fMRI with simultaneous EEG to investigate coupling between gamma frequency neural activity and the BOLD response in humans. Human Brain Mapping, 39(4), 1673-1687. https://doi.org/10.1002/hbm.23943

• Journal Article Type: Article
• Acceptance Date: Dec 21, 2017
• Online Publication Date: Jan 13, 2018
• Publication Date: 2018-04
• Deposit Date: Jan 17, 2018
• Publicly Available Date: Jan 14, 2019
• Journal: Human Brain Mapping
• Print ISSN: 1065-9471
• Electronic ISSN: 1097-0193
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 39
• Issue: 4
• Pages: 1673-1687
• DOI: https://doi.org/10.1002/hbm.23943
• Keywords: EEG-fMRI; Multiband or multislice fMRI; Gamma-BOLD coupling;; Gradient artefacts; Safety; Heating; Motor gamma oscillations
• Public URL: https://nottingham-repository.worktribe.com/output/904341
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1002/hbm.23943/abstract
• Additional Information: This is the peer reviewed version of the following article: Uji M, Wilson R, Francis ST, Mullinger KJ, Mayhew SD. Exploring the advantages of multiband fMRI with simultaneous EEG to investigate coupling between gamma frequency neural activity and the BOLD response in humans. Hum Brain Mapp. 2017;00:1–15, which has been published in final form at https://doi.org/10.1002/hbm.23943. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
• Contract Date: Jan 17, 2018