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All Outputs (4387)

The anthroposcenic (2017)
Journal Article

This paper presents the ‘Anthroposcenic’ as a geographical contribution to debates around the Anthropocene, deploying the insights of cultural and historical geography to ask how thinking through landscape and time might shape understanding. The pape... Read More about The anthroposcenic.

Randomised controlled trial to evaluate the effect of foot trimming before and after first calving on subsequent lameness episodes and productivity in dairy heifers (2017)
Journal Article

The objective of this study was to assess both independent and combined effects of routine foot trimming of heifers at 3 weeks pre-calving and 100 days post calving on the first lactation lameness and lactation productivity. A total of 419 pre-calvin... Read More about Randomised controlled trial to evaluate the effect of foot trimming before and after first calving on subsequent lameness episodes and productivity in dairy heifers.

Combined inkjet printing and infrared sintering of silver nanoparticles using a swathe-by-swathe and layer-by-layer approach for 3-dimensional structures (2017)
Journal Article

Despite the advancement of additive manufacturing (AM)/3-dimensional (3D) printing, single-step fabrication of multifunctional parts using AM is limited. With the view of enabling multifunctional AM (MFAM), in this study, sintering of metal nanoparti... Read More about Combined inkjet printing and infrared sintering of silver nanoparticles using a swathe-by-swathe and layer-by-layer approach for 3-dimensional structures.

Patient safety incidents involving sick children in primary care in England and Wales: a mixed methods analysis (2017)
Journal Article

Background: The UK performs poorly relative to other economically developed countries on numerous indicators of care quality for children. The contribution of iatrogenic harm to these outcomes is unclear. As primary care is the first point of health... Read More about Patient safety incidents involving sick children in primary care in England and Wales: a mixed methods analysis.

Development of Clostridium difficile R20291?PaLoc model strains and in vitro methodologies reveals CdtR is required for the production of CDT to cytotoxic levels (2017)
Journal Article

Assessing the regulation of Clostridium difficile transferase (CDT), is complicated by the presence of a Pathogenicity locus (PaLoc) which encodes Toxins A and B. Here we developed R20291?PaLoc model strains and cell-based assays to quantify CDT-medi... Read More about Development of Clostridium difficile R20291?PaLoc model strains and in vitro methodologies reveals CdtR is required for the production of CDT to cytotoxic levels.

High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with acidic stores (lysosomes) in the heart (2017)
Journal Article

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) stimulates calcium release from acidic stores such as lysosomes and is a highly potent calcium-mobilising second messenger. NAADP plays an important role in calcium signalling in the heart under b... Read More about High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with acidic stores (lysosomes) in the heart.

Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer (2017)
Journal Article

Inflammatory breast cancer (IBC) is a virulent form of breast cancer, and novel treatment strategies are urgently needed. Immunohistochemical analysis of tumors from women with a clinical diagnosis of IBC (n = 147) and those with non-IBC breast cance... Read More about Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer.