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3D printed fluidics with embedded analytic functionality for automated reaction optimisation

Capel, Andrew J.; Wright, Andrew; Harding, Matthew J.; Weaver, George W.; Li, Yuqi; Harris, Russell A.; Edmondson, Steve; Goodridge, Ruth D.; Christie, Steven D.R.

Authors

Andrew J. Capel

Andrew Wright

Matthew J. Harding

George W. Weaver

Yuqi Li

Russell A. Harris

Steve Edmondson

Ruth D. Goodridge

Steven D.R. Christie



Abstract

Additive manufacturing or ‘3D printing’ is being developed as a novel manufacturing process for the production of bespoke micro- and milliscale fluidic devices. When coupled with online monitoring and optimisation software, this offers an advanced, customised method for performing automated chemical synthesis. This paper reports the use of two additive manufacturing processes, stereolithography and selective laser melting, to create multifunctional fluidic devices with embedded reaction monitoring capability. The selectively laser melted parts are the first published examples of multifunctional 3D printed metal fluidic devices. These devices allow high temperature and pressure chemistry to be performed in solvent systems destructive to the majority of devices manufactured via stereolithography, polymer jetting and fused deposition modelling processes previously utilised for this application. These devices were integrated with commercially available flow chemistry, chromatographic and spectroscopic analysis equipment, allowing automated online and inline optimisation of the reaction medium. This set-up allowed the optimisation of two reactions, a ketone functional group interconversion and a fused polycyclic heterocycle formation, via spectroscopic and chromatographic analysis.

Journal Article Type Article
Publication Date Jan 18, 2017
Journal Beilstein Journal of Organic Chemistry
Print ISSN 1860-5397
Electronic ISSN 1860-5397
Publisher Beilstein-Institut
Peer Reviewed Peer Reviewed
Volume 13
APA6 Citation Capel, A. J., Wright, A., Harding, M. J., Weaver, G. W., Li, Y., Harris, R. A., …Christie, S. D. (2017). 3D printed fluidics with embedded analytic functionality for automated reaction optimisation. Beilstein Journal of Organic Chemistry, 13, https://doi.org/10.3762/bjoc.13.14
DOI https://doi.org/10.3762/bjoc.13.14
Keywords 3D printing; Inline reaction analysis; Reaction optimisation; Selective laser melting; Stereolithography
Publisher URL http://http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-13-14
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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