All Outputs (145)

Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications (2017)
Journal Article
Rogerson, D., Williams, J. P., Yates, S., & Rogers, E. (2017). Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications. European Journal of Anaesthesiology, 34(8), 492-507. https://doi.org/10.1097/EJA.0000000000000646

BACKGROUND Limited information exists about the epidemiology and outcome of surgical patients at increased risk of postoperative pulmonary complications (PPCs), and how intraoperative ventilation was managed in these patients. OBJECTIVES To determin... Read More about Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications.

Controversial issues in the management of older adults with early breast cancer (2017)
Journal Article
Mislang, A. R., Cheung, K., Hamaker, M. E., Kunkler, I., Markopoulos, C., Orecchia, R., …Biganzoli, L. (in press). Controversial issues in the management of older adults with early breast cancer. Journal of Geriatric Oncology, https://doi.org/10.1016/j.jgo.2017.05.004

It is well recognized that the incidence of breast cancer increases significantly with age. Despite this, older people remain under-represented in many clinical trials and their management relies on extrapolation of data from younger patients. Provid... Read More about Controversial issues in the management of older adults with early breast cancer.

The use of an online support group for neuromuscular disorders: a thematic analysis of message postings (2017)
Journal Article
Meade, O., Buchanan, H., & Coulson, N. S. (2018). The use of an online support group for neuromuscular disorders: a thematic analysis of message postings. Disability and Rehabilitation, 40(19), 2300-2310. https://doi.org/10.1080/09638288.2017.1334239

Purpose: People affected by neuromuscular disorders can experience adverse psychosocial consequences and difficulties accessing information and support. Online support groups provide new opportunities for peer support. The aim of this study was to un... Read More about The use of an online support group for neuromuscular disorders: a thematic analysis of message postings.

A validation of the Nottingham Clavicle Score: a clavicle, acromioclavicular joint and sternoclavicular joint–specific patient-reported outcome measure (2017)
Journal Article
Charles, E. R., Kumar, V., Blacknall, J., Edwards, K. L., Geoghegan, J. M., Manning, P. A., & Wallace, W. A. (2017). A validation of the Nottingham Clavicle Score: a clavicle, acromioclavicular joint and sternoclavicular joint–specific patient-reported outcome measure. Journal of Shoulder and Elbow Surgery, 26(10), https://doi.org/10.1016/j.jse.2017.03.036

Background Patients with acromioclavicular joint (ACJ) and sternoclavicular joint (SCJ) injuries and with clavicle fractures are typically younger and more active than those with other shoulder pathologies. We developed the Nottingham Clavicle Sco... Read More about A validation of the Nottingham Clavicle Score: a clavicle, acromioclavicular joint and sternoclavicular joint–specific patient-reported outcome measure.

Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis (2017)
Journal Article
Valdes, A. M., Abhishek, A., Muir, K., Zhang, W., Maciewicz, R. A., & Doherty, M. (2017). Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis. Arthritis Care and Research, 69(7), 1076-1081. https://doi.org/10.1002/acr.23091

Objective: Recent findings suggest that β-adrenergic blockers have anti-nociceptive properties. The aim of this study was to compare levels of large joint pain between those on adrenergic blockers and those on other antihypertensive medications. Met... Read More about Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis.

Clinical assessment of gastric emptying and sensory function utilizing gamma scintigraphy: Establishment of reference intervals for the liquid and solid components of the Nottingham test meal in healthy subjects (2017)
Journal Article
Parker, H. L., Tucker, E., Blackshaw, E., Hoad, C., Marciani, L., Perkins, A., …Fox, M. (2017). Clinical assessment of gastric emptying and sensory function utilizing gamma scintigraphy: Establishment of reference intervals for the liquid and solid components of the Nottingham test meal in healthy subjects. Neurogastroenterology and Motility, 29(11), e13122. https://doi.org/10.1111/nmo.13122

Background: Current investigations of stomach function are based on small test meals that do not reliably induce symptoms and analysis techniques that rarely detect clinically relevant dysfunction. This study presents the reference intervals of the m... Read More about Clinical assessment of gastric emptying and sensory function utilizing gamma scintigraphy: Establishment of reference intervals for the liquid and solid components of the Nottingham test meal in healthy subjects.

Ciclosporin compared to prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial (2017)
Journal Article
Mason, J., Thomas, K., Ormerod, A., Craig, F., Mitchell, E., Norrie, J., & Williams, H. (2017). Ciclosporin compared to prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial. British Journal of Dermatology, 177(6), 1527-1536. https://doi.org/10.1111/bjd.15561

Background Pyoderma gangrenosum (PG) is a painful, ulcerating skin disease with poor evidence for management. Prednisolone and ciclosporin are the most commonly used treatments, although not previously compared within a randomised controlled trial... Read More about Ciclosporin compared to prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial.

Impact of stimulus-related factors and hearing impairment on listening effort as indicated by pupil dilation (2017)
Journal Article
Ohlenforst, B., Zekveld, A. A., Lunner, T., Wendt, D., Naylor, G., Wang, Y., …Kramer, S. E. (2017). Impact of stimulus-related factors and hearing impairment on listening effort as indicated by pupil dilation. Hearing Research, 351, https://doi.org/10.1016/j.heares.2017.05.012

Previous research has reported effects of masker type and signal-to-noise ratio (SNR) on listening effort, as indicated by the peak pupil dilation (PPD) relative to baseline during speech recognition. At about 50% correct sentence recognition perform... Read More about Impact of stimulus-related factors and hearing impairment on listening effort as indicated by pupil dilation.

An assessment of the clinical acceptability of direct acoustic cochlear implantation for adults with advanced otosclerosis in the United Kingdom (2017)
Journal Article
Kitterick, P. T., Reddy-Kolanu, G., Baguley, D., Lavy, J., Monksfield, P., Banga, R., …O'Donoghue, G. (2017). An assessment of the clinical acceptability of direct acoustic cochlear implantation for adults with advanced otosclerosis in the United Kingdom. Otology and Neurotology, 38(7), https://doi.org/10.1097/MAO.0000000000001450

Hypothesis: Assess the clinical acceptability of direct acoustic cochlear implantation for patients with advanced otosclerosis and the support for conducting a controlled trial of its effectiveness in the United Kingdom. Background: Emerging evide... Read More about An assessment of the clinical acceptability of direct acoustic cochlear implantation for adults with advanced otosclerosis in the United Kingdom.

Attitudes of older people with mild dementia and mild cognitive impairment and their relatives about falls risk and prevention: a qualitative study (2017)
Journal Article
Peach, T., Pollock, K., van der Wardt, V., das Nair, R., Logan, P., & Harwood, R. H. (2017). Attitudes of older people with mild dementia and mild cognitive impairment and their relatives about falls risk and prevention: a qualitative study. PLoS ONE, 12(5), 1-15. https://doi.org/10.1371/journal.pone.0177530

Objective: To explore the perceptions of older people with mild dementia and mild cognitive impairment, and their family carers, about falling, falls risk and the acceptability of falls prevention interventions. Design: Qualitative study involving t... Read More about Attitudes of older people with mild dementia and mild cognitive impairment and their relatives about falls risk and prevention: a qualitative study.

Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER (2017)
Journal Article
Chen, C., Sigurdsson, H. P., Pépés, S. E., Auer, D. P., Morris, P. G., Morgan, P. S., …Jackson, S. R. (2017). Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER. NeuroImage, 156, 207-213. https://doi.org/10.1016/j.neuroimage.2017.05.044

Functional magnetic resonance spectroscopy (fMRS) has been used to assess the dynamic metabolic responses of the brain to a physiological stimulus non-invasively. However, only limited information on the dynamic functional response of γ-aminobutyric... Read More about Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER.

First validation of the gout activity score against gout impact scale in a primary care based gout cohort (2017)
Journal Article
La-Crette, J., Jenkins, W., Fernandes, G. S., Valdes, A. M., Doherty, M., & Abhishek, A. (in press). First validation of the gout activity score against gout impact scale in a primary care based gout cohort. Joint Bone Spine, https://doi.org/10.1016/j.jbspin.2017.05.010

Objectives To validate the gout activity score (GAS) against the gout impact scale in a primary care based gout cohort. Methods This was a single-centre cross-sectional study. People with gout who participated in previous research at Academic Rheuma... Read More about First validation of the gout activity score against gout impact scale in a primary care based gout cohort.

Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene (2017)
Journal Article
Warner, S., Walsh, D. A., Laslett, L., Maciewicz, R., Soni, A., Hart, D., …Valdes, A. M. (2017). Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene. European Journal of Pain, 21(7), 1277-1284. https://doi.org/10.1002/ejp.1027

Background: Substance P (SP) is a pain- and inflammation-related neuropeptide which preferentially binds to the neurokinin receptor 1 (NK1). SP and NK1 receptors have been implicated in joint pain, inflammation and damage in animal models and human s... Read More about Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene.

Assessment of motion of colonic contents in the human colon using MRI tagging (2017)
Journal Article
Pritchard, S. E., Paul, J., Major, G., Marciani, L., Gowland, P. A., Spiller, R. C., & Hoad, C. (2017). Assessment of motion of colonic contents in the human colon using MRI tagging. Neurogastroenterology and Motility, 29(9), Article e13091. https://doi.org/10.1111/nmo.13091

Background We have previously reported a non-invasive, semi-automated technique to assess motility of the wall of the ascending colon (AC) using Magnetic Resonance Imaging. This study investigated the feasibility of using a tagged MRI technique to vi... Read More about Assessment of motion of colonic contents in the human colon using MRI tagging.

Interruption to antiplatelet therapy early after acute ischaemic stroke: a nested case-control study (2017)
Journal Article
Mazlan-Kepli, W., Macisaac, R. L., Walters, M., Bath, P. M. W., & Dawson, J. (2017). Interruption to antiplatelet therapy early after acute ischaemic stroke: a nested case-control study. British Journal of Clinical Pharmacology, 83(9), https://doi.org/10.1111/bcp.13290

Aims: Antiplatelet drugs are often discontinued early after ischaemic stroke, either because of poor compliance, complications or withdrawal of care. It is unclear whether this places patients at increased risk of recurrence. We explored the associat... Read More about Interruption to antiplatelet therapy early after acute ischaemic stroke: a nested case-control study.

The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis (2017)
Journal Article
Amer, S. A., Shamy, T. T. E., James, C., Yosef, A. H., & Mohamed, A. A. (2017). The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis. Reproduction, 154(1), R13-R21. https://doi.org/10.1530/REP-17-0063

Laparoscopic ovarian drilling (LOD) has been widely used as an effective treatment of anovulatory women with polycystic ovarian syndrome (PCOS). However, there has been a growing concern over a possible damaging effect of this procedure on ovarian re... Read More about The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis.

The role of CB1 in intestinal permeability and inflammation (2017)
Journal Article
Karwad, M. A., Couch, D. G., Theophilidou, E., Sarmad, S., Barrett, D. A., Larvin, M., …O'Sullivan, S. (2017). The role of CB1 in intestinal permeability and inflammation. FASEB Journal, 31(8), 3267-3277. https://doi.org/10.1096/fj.201601346R

The endocannabinoid system has previously been shown to play a role in the permeability and inflammatory response of the human gut. The goal of our study was to determine the effects of endogenous anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) o... Read More about The role of CB1 in intestinal permeability and inflammation.

Antipsychotic treatment resistance in first-episode psychosis: prevalence, subtypes and predictors (2017)
Journal Article
Demjaha, A., Demjaha, A., Lappin, J. M., Stahl, D., Patel, M. X., MacCabe, J. H., …Murray, R. M. (2017). Antipsychotic treatment resistance in first-episode psychosis: prevalence, subtypes and predictors. Psychological Medicine, 47(11), 1981-1989. https://doi.org/10.1017/S0033291717000435

Background: We examined longitudinally the course and predictors of treatment resistance in a large cohort of first-episode psychosis (FEP) patients from initiation of antipsychotic treatment. We hypothesized that antipsychotic treatment resistance i... Read More about Antipsychotic treatment resistance in first-episode psychosis: prevalence, subtypes and predictors.

Vision zero: from accident prevention to the promotion of health, safety and well-being at work (2017)
Journal Article
Zwetsloot, G., Leka, S., & Kines, P. (in press). Vision zero: from accident prevention to the promotion of health, safety and well-being at work. Policy and Practice in Health and Safety, 15(2), https://doi.org/10.1080/14773996.2017.1308701

There is growing attention in industry for the Vision Zero strategy, which in terms of work-related health and safety is often labelled as Zero Accident Vision or Zero Harm. The consequences of a genuine commitment to Vision Zero for addressing healt... Read More about Vision zero: from accident prevention to the promotion of health, safety and well-being at work.

Exploring barriers to South Asian help-seeking for eatingdisorders (2017)
Journal Article
Wales, J., Brewin, N., Raghavan, R., & Arcelus, J. (2017). Exploring barriers to South Asian help-seeking for eatingdisorders. Mental Health Review Journal, 22(1), 40-50. https://doi.org/10.1108/MHRJ-09-2016-0017

Purpose: Referrals to specialist eating disorder (ED) services from the South Asian (SA) community are under-represented, despite research suggesting that disordered eating attitudes and behaviours of SA people are similar to the population in genera... Read More about Exploring barriers to South Asian help-seeking for eatingdisorders.