Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis

Valdes, Ana M.; Abhishek, Abhishek; Muir, Kenneth; Zhang, Weiya; Maciewicz, Rose A.; Doherty, Michael

Abstract

Objective: Recent findings suggest that β-adrenergic blockers have anti-nociceptive properties. The aim of this study was to compare levels of large joint pain between those on adrenergic blockers and those on other antihypertensive medications.
Methods: Data from the GOAL study, a secondary care cohort of osteoarthritis (OA), were used. Joint pain was assessed using the Western Ontario and McMaster Universities Arthritis (WOMAC) pain score in 873 individuals who had symptomatic hip and/or knee OA and hypertension, and who were on ≥1 prescription antihypertensive medications. The association between adrenergic blocker prescription and a) at least moderate joint pain (WOMAC

Citation

Valdes, A. M., Abhishek, A., Muir, K., Zhang, W., Maciewicz, R. A., & Doherty, M. (2017). Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis. Arthritis Care and Research, 69(7), 1076-1081. https://doi.org/10.1002/acr.23091

• Journal Article Type: Article
• Acceptance Date: Sep 13, 2016
• Online Publication Date: Jun 7, 2017
• Publication Date: Jun 27, 2017
• Deposit Date: Jan 27, 2017
• Publicly Available Date: Jun 7, 2017
• Journal: Arthritis Care & Research
• Print ISSN: 2151-464X
• Electronic ISSN: 2151-4658
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 69
• Issue: 7
• Pages: 1076-1081
• DOI: https://doi.org/10.1002/acr.23091
• Public URL: https://nottingham-repository.worktribe.com/output/868289
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1002/acr.23091/full
• Additional Information: This is the peer reviewed version of the following article: Valdes, A. M., Abhishek, A., Muir, K., Zhang, W., Maciewicz, R. A. and Doherty, M. (2017), Association of Beta-Blocker Use With Less Prevalent Joint Pain and Lower Opioid Requirement in People With Osteoarthritis. Arthritis Care & Research. doi:10.1002/acr.23091 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/acr.23091/full This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.