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Full hydrodynamic reversibility of the weak dimerization of vancomycin and elucidation of its interaction with VanS monomers at clinical concentration (2017)
Journal Article
Phillips-Jones, M. K., Lithgo, R., Dinu, V., Gillis, R. B., Harding, J. E., Adams, G. G., & Harding, S. E. (2017). Full hydrodynamic reversibility of the weak dimerization of vancomycin and elucidation of its interaction with VanS monomers at clinical concentration. Scientific Reports, 7(1), 1-10. https://doi.org/10.1038/s41598-017-12620-z

The reversibility and strength of the previously established dimerization of the important glycopeptide antibiotic vancomycin in four different aqueous solvents (including a medically-used formulation) have been studied using short-column sedimentati... Read More about Full hydrodynamic reversibility of the weak dimerization of vancomycin and elucidation of its interaction with VanS monomers at clinical concentration.

Glargine and degludec: solution behaviour of higher dose synthetic insulins (2017)
Journal Article
Adams, G. G., Alzahrani, Q., Jiwani, S. I., Meal, A., Morgan, P. S., Coffey, F., …Gillis, R. B. (2017). Glargine and degludec: solution behaviour of higher dose synthetic insulins. Scientific Reports, 7(1), Article 7287. https://doi.org/10.1038/s41598-017-06642-w

Single, double and triple doses of the synthetic insulins glargine and degludec currently used in patient therapy are characterised using macromolecular hydrodynamic techniques (dynamic light scattering and analytical ultracentrifugation) in an attem... Read More about Glargine and degludec: solution behaviour of higher dose synthetic insulins.

In situ polymerisation of isoeugenol as a green consolidation method for waterlogged archaeological wood (2017)
Journal Article
McHale, E., Steindal, C. C., Kutzke, H., Benneche, T., & Harding, S. E. (2017). In situ polymerisation of isoeugenol as a green consolidation method for waterlogged archaeological wood. Scientific Reports, 7, Article 46481. https://doi.org/10.1038/srep46481

Waterlogged archaeological wood is often in need of consolidation prior to drying to prevent shrinkage and cracking of the object. There is a need for new greener materials (than for example polyethylene glycol) and methods for consolidation to be de... Read More about In situ polymerisation of isoeugenol as a green consolidation method for waterlogged archaeological wood.

Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin (2017)
Journal Article
Phillips-Jones, M. K., Channell, G. A., Kelsall, C. J., Hughes, C. S., Ashcroft, A. E., Patching, S. G., …Harding, S. E. (2017). Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin. Scientific Reports, 7(1), 1-12. https://doi.org/10.1038/srep46180

VanA-type resistance to glycopeptide antibiotics in clinical enterococci is regulated by the VanSARA two-component signal transduction system. The nature of the molecular ligand that is recognised by the VanSA sensory component has not hitherto been... Read More about Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin.