All Outputs (4)

Common polygenic variation can predict risk of Alzheimer’s disease (2015)
Journal Article
Escott-Price, V., Sims, R., Bannister, C., Harold, D., Vronskaya, M., Majounie, E., …Williams, J. (2015). Common polygenic variation can predict risk of Alzheimer’s disease. Brain, https://doi.org/10.1093/brain/awv268

Background: The identification of subjects at high risk for Alzheimer’s disease is important for prognosis and early intervention. We investigated the polygenic architecture of Alzheimer’s disease (AD) and the accuracy of AD prediction models, includ... Read More about Common polygenic variation can predict risk of Alzheimer’s disease.

Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility (2015)
Journal Article
Sevlever, D., Zou, F., Ma, L., Carrasquillo, S., Crump, M. G., Culley, O. J., …Belbin, O. (2015). Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility. Molecular Neurodegeneration, 10, Article 18. https://doi.org/10.1186/s13024-015-0015-x

Background Alzheimer’s disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of hyperphosphorylated tau and ce... Read More about Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility.

Blood type gene locus has no influence on ACE association with Alzheimer's disease (2015)
Journal Article
Braae, A., Medway, C., Carrasquillo, M., Younkin, S., Kehoe, P. G., & Morgan, K. (2015). Blood type gene locus has no influence on ACE association with Alzheimer's disease. Neurobiology of Aging, 36(4), Article 1767.e1-1767.e2. https://doi.org/10.1016/j.neurobiolaging.2015.01.013

The ABO blood group locus was recently found to contribute independently as well as via interactions with ACE gene variation to plasma levels of angiotensin converting enzyme (ACE). Variation in ACE has also previously been implicated as conferring s... Read More about Blood type gene locus has no influence on ACE association with Alzheimer's disease.

A novel Alzheimer disease locus located near the gene encoding tau protein (2015)
Journal Article
Jun, G., Ibrahim-Verbaas, C. A., Vronskaya, M., Lambert, J., Chung, J., Naj, A. C., …Morgan, K. (2015). A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular Psychiatry, 21, https://doi.org/10.1038/mp.2015.23

APOE ε4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’s Project (IGAP) Consortium in APOE ε4... Read More about A novel Alzheimer disease locus located near the gene encoding tau protein.