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Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility

Sevlever, Daniel; Zou, Fanggeng; Ma, Li; Carrasquillo, Sebastian; Crump, Michael G.; Culley, Oliver J.; Hunter, Talisha A.; Bisceglio, Gina D.; Younkin, Linda; Allen, Mariet; Carrasquillo, Minerva M.; Sando, Sigrid B.; Aasly, Jan O.; Dickson, Dennis W.; Graff-Radford, Neill R.; Petersen, Ronald C.; Morgan, Kevin; Belbin, Olivia

Authors

Daniel Sevlever

Fanggeng Zou

Li Ma

Sebastian Carrasquillo

Michael G. Crump

Oliver J. Culley

Talisha A. Hunter

Gina D. Bisceglio

Linda Younkin

Mariet Allen

Minerva M. Carrasquillo

Sigrid B. Sando

Jan O. Aasly

Dennis W. Dickson

Neill R. Graff-Radford

Ronald C. Petersen

KEVIN MORGAN kevin.morgan@nottingham.ac.uk
Professor of Human Genomics and Molecular Genetics

Olivia Belbin



Abstract

Background

Alzheimer’s disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of hyperphosphorylated tau and cell death. Since proteins in the SNAP (Soluble N-ethylmaleimide-sensitive factor Attachment Protein) REceptors (SNARE) complex are essential for neuronal Aβ release at pre-synaptic terminals, we hypothesized that genetically controlled SNARE expression could alter neuronal Aß release at the synapse and hence play an early role in Alzheimer’s pathophysiology.

Results

Here we report 5 polymorphisms in Vesicle-Associated Membrane Protein 1 (VAMP1), a gene encoding a member of the SNARE complex, associated with bidirectionally altered cerebellar VAMP1 transcript levels (all p 

Journal Article Type Article
Publication Date Apr 9, 2015
Journal Molecular Neurodegeneration
Electronic ISSN 1750-1326
Publisher Humana Press
Peer Reviewed Peer Reviewed
Volume 10
Article Number 18
APA6 Citation Sevlever, D., Zou, F., Ma, L., Carrasquillo, S., Crump, M. G., Culley, O. J., …Belbin, O. (2015). Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility. Molecular Neurodegeneration, 10, doi:10.1186/s13024-015-0015-x
DOI https://doi.org/10.1186/s13024-015-0015-x
Keywords SNARE, Vesicle-Associated Membrane Protein 1, β-amyloid, Alzheimer’s disease, Synapse
Publisher URL http://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-015-0015-x
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0



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