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A novel Alzheimer disease locus located near the gene encoding tau protein

Jun, Gyungah; Ibrahim-Verbaas, Carla A.; Vronskaya, Maria; Lambert, Jean-Charles; Chung, Jaeyoon; Naj, Adam C.; Kunkle, Brian W.; Wang, Li-San; Bis, Joshua C.; Bellenguez, Céline; Harold, Denise; Lunetta, Kathryn L.; Destefano, Anita L.; Grenier-Boley, Benjamin; Sims, Rebecca; Morgan, Kevin

Authors

Gyungah Jun

Carla A. Ibrahim-Verbaas

Maria Vronskaya

Jean-Charles Lambert

Jaeyoon Chung

Adam C. Naj

Brian W. Kunkle

Li-San Wang

Joshua C. Bis

Céline Bellenguez

Denise Harold

Kathryn L. Lunetta

Anita L. Destefano

Benjamin Grenier-Boley

Rebecca Sims

KEVIN MORGAN kevin.morgan@nottingham.ac.uk
Professor of Human Genomics and Molecular Genetics



Abstract

APOE ε4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’s Project (IGAP) Consortium in APOE ε4+ (10,352 cases and 9,207 controls) and APOE ε4- (7,184 cases and 26,968 controls) subgroups as well as in the total sample testing for interaction between a SNP and APOE ε4 status. Suggestive associations (P

Citation

Jun, G., Ibrahim-Verbaas, C. A., Vronskaya, M., Lambert, J., Chung, J., Naj, A. C., …Morgan, K. (2015). A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular Psychiatry, 21, https://doi.org/10.1038/mp.2015.23

Journal Article Type Article
Acceptance Date Jan 8, 2015
Publication Date Mar 17, 2015
Deposit Date Mar 3, 2016
Publicly Available Date Mar 3, 2016
Journal Molecular Psychiatry
Print ISSN 1359-4184
Electronic ISSN 1476-5578
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 21
DOI https://doi.org/10.1038/mp.2015.23
Public URL http://eprints.nottingham.ac.uk/id/eprint/32100
Publisher URL http://www.nature.com/mp/journal/v21/n1/full/mp201523a.html
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
Additional Information 117 authors.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf



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