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A novel Alzheimer disease locus located near the gene encoding tau protein

Jun, Gyungah; Ibrahim-Verbaas, Carla A.; Vronskaya, Maria; Lambert, Jean-Charles; Chung, Jaeyoon; Naj, Adam C.; Kunkle, Brian W.; Wang, Li-San; Bis, Joshua C.; Bellenguez, Céline; Harold, Denise; Lunetta, Kathryn L.; Destefano, Anita L.; Grenier-Boley, Benjamin; Sims, Rebecca; Morgan, Kevin

Authors

Gyungah Jun

Carla A. Ibrahim-Verbaas

Maria Vronskaya

Jean-Charles Lambert

Jaeyoon Chung

Adam C. Naj

Brian W. Kunkle

Li-San Wang

Joshua C. Bis

Céline Bellenguez

Denise Harold

Kathryn L. Lunetta

Anita L. Destefano

Benjamin Grenier-Boley

Rebecca Sims

KEVIN MORGAN kevin.morgan@nottingham.ac.uk
Professor of Human Genomics and Molecular Genetics



Abstract

APOE ε4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’s Project (IGAP) Consortium in APOE ε4+ (10,352 cases and 9,207 controls) and APOE ε4- (7,184 cases and 26,968 controls) subgroups as well as in the total sample testing for interaction between a SNP and APOE ε4 status. Suggestive associations (P

Journal Article Type Article
Publication Date Mar 17, 2015
Journal Molecular Psychiatry
Print ISSN 1359-4184
Electronic ISSN 1476-5578
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 21
APA6 Citation Jun, G., Ibrahim-Verbaas, C. A., Vronskaya, M., Lambert, J., Chung, J., Naj, A. C., …Morgan, K. (2015). A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular Psychiatry, 21, https://doi.org/10.1038/mp.2015.23
DOI https://doi.org/10.1038/mp.2015.23
Publisher URL http://www.nature.com/mp/journal/v21/n1/full/mp201523a.html
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information 117 authors.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf



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