All Outputs (1292)

Computational assessment of drug-induced effects on the electrocardiogram: From ion channel to body surface potentials (2013)
Journal Article

Background and Purpose: Understanding drug effects on the heart is key to safety pharmacology assessment and anti-arrhythmic therapy development. Here our goal is to demonstrate the ability of computational models to simulate the effect of drug actio... Read More about Computational assessment of drug-induced effects on the electrocardiogram: From ion channel to body surface potentials.

Exploitation of interspecific diversity for monocot crop improvement (2013)
Journal Article

In many cultivated crop species there is limited genetic variation available for the development of new higher yielding varieties adapted to climate change and sustainable farming practises. The distant relatives of crop species provide a vast and la... Read More about Exploitation of interspecific diversity for monocot crop improvement.

Psychological and social factors influencing patients' treatment selection for localised prostate cancer (2013)
Book Chapter

Chapter 3. Prostate cancer is the most common form of cancer in men in the United Kingdom (UK). A quarter of all new cases of cancer diagnosed in men are prostate cancers. In 2009, over 40,000 cases of prostate cancer were reported in the UK and m... Read More about Psychological and social factors influencing patients' treatment selection for localised prostate cancer.

Analysing the hidden curriculum: use of a cultural web (2013)
Journal Article

CONTEXT Major influences on learning about medical professionalism come from the hidden curriculum. These influences can contribute positively or negatively towards the professional enculturation of clinical students. The fact that there is no valid... Read More about Analysing the hidden curriculum: use of a cultural web.

Acute intestinal obstruction secondary to left paraduodenal hernia: a case report and literature review (2013)
Journal Article

Introduction: An internal hernia is a protrusion of bowel through a normal or abnormal orifice in the peritoneum or mesentery. Although they are considered as a rare cause of intestinal obstruction, paraduodenal hernias are the most common type of... Read More about Acute intestinal obstruction secondary to left paraduodenal hernia: a case report and literature review.

Empowering processes within prostate cancer online support groups (2013)
Journal Article

A growing body of literature suggests that participation in online support groups may empower patients. Indeed, a number of potentially empowering processes have been identified, however to date these processes have been described using data derived... Read More about Empowering processes within prostate cancer online support groups.

Abnormal T regulatory cells (Tregs: FOXP3+, CTLA-4+), myeloid-derived suppressor cells (MDSCs: monocytic, granulocytic) and polarised T helper cell profiles (Th1, Th2, Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC (2013)
Journal Article

Background: Host defences play a key role in tumour growth. Some of the benefits of chemotherapy may occur through modulation of these defences. The aim of this study was to define the status of regulatory cells in women with large and locally advanc... Read More about Abnormal T regulatory cells (Tregs: FOXP3+, CTLA-4+), myeloid-derived suppressor cells (MDSCs: monocytic, granulocytic) and polarised T helper cell profiles (Th1, Th2, Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC.

Light drinking in pregnancy and mid-childhood mental health and learning outcomes (2013)
Journal Article

OBJECTIVE: To investigate whether light drinking in pregnancy is associated with adverse child mental health and academic outcomes. DESIGN: Using data from the prospective, population-based Avon Longitudinal Study of Parents and Children (ALSPAC),... Read More about Light drinking in pregnancy and mid-childhood mental health and learning outcomes.

The destruction mechanism in GCTs (2013)
Journal Article

This paper focuses on the causes that lead to the final destruction in standard gate-commutated thyristor (GCT) devices. A new 3-D model approach has been used for simulating the GCT which provides a deep insight into the operation of the GCT in extr... Read More about The destruction mechanism in GCTs.

Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line (2013)
Journal Article

Polymer particles consisting of a biodegradable poly[lactide-co-glycolide] (PLGA) core and a thermoresponsive shell have been formulated to encapsulate the dye rhodamine 6G and the potent cytotoxic drug paclitaxel. Cellular uptake of these particles... Read More about Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line.

Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring (2013)
Journal Article

Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in the distortion of early male reproductive development, referred to in humans as the testicular dysgenesis syndrome. It is not known, however, whether such early gestatio... Read More about Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring.

Threshold criteria for incipient sediment motion on an inclined bedform in the presence of oscillating-grid turbulence (2013)
Journal Article

Here, we report laboratory experiments to investigate the threshold criteria for incipient sediment motion in the presence of oscillating-grid turbulence, with the bed slope inclined at angles between the horizontal and the repose limit for the sedim... Read More about Threshold criteria for incipient sediment motion on an inclined bedform in the presence of oscillating-grid turbulence.

Axillary treatment for patients with early breast cancer and lymph node metastasis: systematic review protocol (2013)
Journal Article

Background: For patients with early breast cancer and lymph node metastasis, axillary treatment is widely recommended. This is either surgical removal of the axillary lymph nodes, or axillary radiotherapy. The rationale for axillary treatment is that... Read More about Axillary treatment for patients with early breast cancer and lymph node metastasis: systematic review protocol.

Hsmar1 transposition is sensitive to the topology of the transposon donor and the target (2013)
Journal Article

Hsmar1 is a member of the Tc1-mariner superfamily of DNA transposons. These elements mobilize within the genome of their host by a cut-and-paste mechanism. We have exploited the in vitro reaction provided by Hsmar1 to investigate the effect of DNA su... Read More about Hsmar1 transposition is sensitive to the topology of the transposon donor and the target.

A global assessment of the effects of climate policy on the impacts of climate change (2013)
Journal Article

This study presents the first global-scale multi-sectoral regional assessment of the magnitude and uncertainty in the impacts of climate change avoided by emissions policies. The analysis suggests that the most stringent emissions policy considered h... Read More about A global assessment of the effects of climate policy on the impacts of climate change.

Association of season and herd size with somatic cell count for cows in Irish,English, and Welsh dairy herds (2013)
Journal Article

The aims of this study were to describe associations of time of year, and herd size with cow somatic cell count (SCC) for Irish, English, and Welsh dairy herds. Random samples of 497 and 493 Irish herds, and two samples of 200 English and Welsh (UK)... Read More about Association of season and herd size with somatic cell count for cows in Irish,English, and Welsh dairy herds.

Tuning the mechanical properties of self-assembled mixed-peptide tubes (2013)
Journal Article

In this study, nano- and microscale fibrillar and tubular structures formed by mixing two aromatic peptides known to self-assemble separately, (diphenylalanine and di-D-2-napthylalanine) have been investigated. The morphology, mechanical strength and... Read More about Tuning the mechanical properties of self-assembled mixed-peptide tubes.

Reliability and identification of aortic valve prolapse in the horse (2013)
Journal Article

Background The objectives were to determine and assess the reliability of criteria for identification of aortic valve prolapse (AVP) using echocardiography in the horse. Results Opinion of equine cardiologists indicated that a long-axis view of... Read More about Reliability and identification of aortic valve prolapse in the horse.

The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study (2013)
Journal Article

Background: No studies have investigated the immediate impact of receiving an allogeneic hematopoietic stem cell transplant (HSCT) on pulmonary inflammation or lung function. Methods: Using a prospective study design, we quantified the changes in... Read More about The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study.

Proteomic Analysis of Clathrin Interactions in Trypanosomes Reveals Dynamic Evolution of Endocytosis (2013)
Journal Article

Endocytosis is a vital cellular process maintaining the cell surface, modulating signal transduction and facilitating nutrient acquisition. In metazoa, multiple endocytic modes are recognized, but for many unicellular organisms the process is likely... Read More about Proteomic Analysis of Clathrin Interactions in Trypanosomes Reveals Dynamic Evolution of Endocytosis.