All Outputs (4)

Tissue-specific expression of p73 C-terminal isoforms in mice (2012)
Journal Article
Grespi, F., Amelio, I., Tucci, P., Annicchiarico-Petruzzelli, M., & Melino, G. (2012). Tissue-specific expression of p73 C-terminal isoforms in mice. Cell Cycle, 11(23), 4474-4483. https://doi.org/10.4161/cc.22787

p73 is a p53 family transcription factor. Due to the presence in the 5? flanking region of two promoters, there are two N-terminal variants, TAp73, which retains a fully active transactivation domain (TA), and ?Np73, in which the N terminus is trunca... Read More about Tissue-specific expression of p73 C-terminal isoforms in mice.

The “Sharp” blade against HIF-mediated metastasis (2012)
Journal Article
Amelio, I., & Melino, G. (2012). The “Sharp” blade against HIF-mediated metastasis. Cell Cycle, 11(24), 4530-4535. https://doi.org/10.4161/cc.22820

Hypoxia-inducible factors (HIFs) control cellular adaptation to oxygen deprivation. Cancer cells engage HIFs to sustain their growth in adverse conditions, thus promoting a cellular reprograming that includes metabolism, proliferation, survival and m... Read More about The “Sharp” blade against HIF-mediated metastasis.

p63 the guardian of human reproduction (2012)
Journal Article
Amelio, I., Grespi, F., Annicchiarico-Petruzzelli, M., & Melino, G. (2012). p63 the guardian of human reproduction. Cell Cycle, 11(24), 4545-4551. https://doi.org/10.4161/cc.22819

p63 is a transcriptional factor implicated in cancer and development. The presence in TP63 gene of alternative promoters allows expression of one isoform containing the N-terminal transactivation domain (TA isoform) and one N-terminal truncated isofo... Read More about p63 the guardian of human reproduction.

miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration (2012)
Journal Article
Amelio, I., Lena, A. M., Viticchiè, G., Shalom-Feuerstein, R., Terrinoni, A., Dinsdale, D., …Melino, G. (2012). miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration. Journal of Cell Biology, 199(2), 347-363. https://doi.org/10.1083/jcb.201203134

During keratinocyte differentiation and stratification, cells undergo extensive remodeling of their actin cytoskeleton, which is important to control cell mobility and to coordinate and stabilize adhesive structures necessary for functional epithelia... Read More about miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration.