p63 the guardian of human reproduction

Amelio, Ivano; Grespi, Francesca; Annicchiarico-Petruzzelli, Margherita; Melino, Gerry

Abstract

p63 is a transcriptional factor implicated in cancer and development. The presence in TP63 gene of alternative promoters allows expression of one isoform containing the N-terminal transactivation domain (TA isoform) and one N-terminal truncated isoform (ΔN isoform). Complete ablation of all p63 isoforms produced mice with fatal developmental abnormalities, including lack of epidermal barrier, limbs and other epidermal appendages. Specific TAp63-null mice, although they developed normally, failed to undergo in DNA damage-induced apoptosis during primordial follicle meiotic arrest, suggesting a p63 involvement in maternal reproduction. Recent findings have elucidated the role in DNA damage response of a novel Hominidae p63 isoform, GTAp63, specifically expressed in human spermatic precursors. Thus, these findings suggest a unique strategy of p63 gene, to evolve in order to preserve the species as a guardian of reproduction. Elucidation of the biological basis of p63 function in reproduction may provide novel approaches to the control of human fertility.

Citation

Amelio, I., Grespi, F., Annicchiarico-Petruzzelli, M., & Melino, G. (2012). p63 the guardian of human reproduction. Cell Cycle, 11(24), 4545-4551. https://doi.org/10.4161/cc.22819

• Journal Article Type: Article
• Online Publication Date: Nov 19, 2012
• Publication Date: Dec 15, 2012
• Deposit Date: Apr 1, 2020
• Journal: Cell Cycle
• Print ISSN: 1538-4101
• Electronic ISSN: 1551-4005
• Publisher: Taylor and Francis
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 24
• Pages: 4545-4551
• DOI: https://doi.org/10.4161/cc.22819
• Keywords: p63, oocytes, spermatozoa, reproduction, DNA damage, p53, c-Abl
• Public URL: https://nottingham-repository.worktribe.com/output/4237332
• Publisher URL: https://www.tandfonline.com/doi/full/10.4161/cc.22819