Ivano Amelio
p63 the guardian of human reproduction
Amelio, Ivano; Grespi, Francesca; Annicchiarico-Petruzzelli, Margherita; Melino, Gerry
Authors
Francesca Grespi
Margherita Annicchiarico-Petruzzelli
Gerry Melino
Abstract
p63 is a transcriptional factor implicated in cancer and development. The presence in TP63 gene of alternative promoters allows expression of one isoform containing the N-terminal transactivation domain (TA isoform) and one N-terminal truncated isoform (ΔN isoform). Complete ablation of all p63 isoforms produced mice with fatal developmental abnormalities, including lack of epidermal barrier, limbs and other epidermal appendages. Specific TAp63-null mice, although they developed normally, failed to undergo in DNA damage-induced apoptosis during primordial follicle meiotic arrest, suggesting a p63 involvement in maternal reproduction. Recent findings have elucidated the role in DNA damage response of a novel Hominidae p63 isoform, GTAp63, specifically expressed in human spermatic precursors. Thus, these findings suggest a unique strategy of p63 gene, to evolve in order to preserve the species as a guardian of reproduction. Elucidation of the biological basis of p63 function in reproduction may provide novel approaches to the control of human fertility.
Citation
Amelio, I., Grespi, F., Annicchiarico-Petruzzelli, M., & Melino, G. (2012). p63 the guardian of human reproduction. Cell Cycle, 11(24), 4545-4551. https://doi.org/10.4161/cc.22819
Journal Article Type | Article |
---|---|
Online Publication Date | Nov 19, 2012 |
Publication Date | Dec 15, 2012 |
Deposit Date | Apr 1, 2020 |
Journal | Cell Cycle |
Print ISSN | 1538-4101 |
Electronic ISSN | 1551-4005 |
Publisher | Taylor and Francis |
Peer Reviewed | Peer Reviewed |
Volume | 11 |
Issue | 24 |
Pages | 4545-4551 |
DOI | https://doi.org/10.4161/cc.22819 |
Keywords | p63, oocytes, spermatozoa, reproduction, DNA damage, p53, c-Abl |
Public URL | https://nottingham-repository.worktribe.com/output/4237332 |
Publisher URL | https://www.tandfonline.com/doi/full/10.4161/cc.22819 |
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