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All Outputs (191)

Molecular mechanism of target recognition by subtilin, a class I lanthionine antibiotic (2008)
Journal Article
Parisot, J., Carey, S., Breukink, E., Chan, W. C., Narbad, A., & Bonev, B. (2008). Molecular mechanism of target recognition by subtilin, a class I lanthionine antibiotic. Antimicrobial Agents and Chemotherapy, 52(2), 612-618. https://doi.org/10.1128/AAC.00836-07

The increasing resistance of human pathogens to conventional antibiotics presents a growing threat to the chemotherapeutic management of infectious diseases. The lanthionine antibiotics, still unused as therapeutic agents, have recently attracted sig... Read More about Molecular mechanism of target recognition by subtilin, a class I lanthionine antibiotic.

Panel discussion [of paper: Thyroid disrupting chemicals: mechanisms and mixtures] (2008)
Journal Article
Anand-Ivell, R., Crofton, K., Ivell, R., Köhrle, J., & Kortenkamp, A. (2008). Panel discussion [of paper: Thyroid disrupting chemicals: mechanisms and mixtures]. International Journal of Andrology, 31(2), 222-223. https://doi.org/10.1111/j.1365-2605.2007.00857.x

This is a panel discussion (pages 222-223) of Kevin M. Crofton's paper Thyroid disrupting chemicals: mechanisms and mixtures. Summary of main paper: Environmental contaminants are known to act as thyroid disrupting chemicals (TDCs). Broadly def... Read More about Panel discussion [of paper: Thyroid disrupting chemicals: mechanisms and mixtures].

Association of antibodies to hepatitis C virus glycoproteins 1 and 2 (anti-E1E2) with HCV disease (2008)
Journal Article
Hamed, M. R., Tarr, A. W., McClure, C. P., Ball, J. K., Hickling, T. P., & Irving, W. L. (2008). Association of antibodies to hepatitis C virus glycoproteins 1 and 2 (anti-E1E2) with HCV disease. Journal of Viral Hepatitis, 15(5), 339-345. https://doi.org/10.1111/j.1365-2893.2007.00947.x

Hepatitis C virus (HCV) causes acute and chronic liver diseases in humans. Its two envelope glycoproteins, E1 and E2, provide a target for host immune recognition. HCV genotypes are classified into six genetic groups. To study the role of anti-HCV E1... Read More about Association of antibodies to hepatitis C virus glycoproteins 1 and 2 (anti-E1E2) with HCV disease.

Antibodies that identify only the active conformation of G(i) family G protein alpha subunits (2008)
Journal Article
Lane, J. R., Henderson, D., Powney, B., Wise, A., Rees, S., Daniels, D., …Milligan, G. (2008). Antibodies that identify only the active conformation of G(i) family G protein alpha subunits. FASEB Journal, 22(6), 1924-1932. https://doi.org/10.1096/fj.07-100388

Production of antisera able to recognize individual heterotrimeric G protein alpha subunits resulted in rapid expansion of information on their distribution and function. However, no antibodies that specifically recognize the active state have been a... Read More about Antibodies that identify only the active conformation of G(i) family G protein alpha subunits.

Stroke outcome in clinical trial patients deriving from different countries (2008)
Journal Article
Ali, M., Atula, S., Bath, P. M., Grotta, J., Hacke, W., Lyden, P. D., …Lees, K. R. (2008). Stroke outcome in clinical trial patients deriving from different countries. Stroke, 40(1), https://doi.org/10.1161/STROKEAHA.108.518035

Background and Purpose—Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across geographical locations rem... Read More about Stroke outcome in clinical trial patients deriving from different countries.

p53 represses human papillomavirus type 16 DNA replication via the viral E2 protein (2008)
Journal Article
Brown, C., Kowalczyk, A. M., Taylor, E. R., Morgan, I. M., & Gaston, K. (2008). p53 represses human papillomavirus type 16 DNA replication via the viral E2 protein. Virology Journal, 5, doi:10.1186/1743-422X-5-5

Background. Human papillomavirus (HPV) DNA replication can be inhibited by the cellular tumour suppressor protein p53. However, the mechanism through which p53 inhibits viral replication and the role that this might play in the HPV life cycle are not... Read More about p53 represses human papillomavirus type 16 DNA replication via the viral E2 protein.

Differential acetylation of histone H4 lysine during development of in vitro fertilized, cloned and parthenogenetically activated bovine embryos (2008)
Journal Article
Maalouf, W. E., Alberio, R., & Campbell, K. H. (2008). Differential acetylation of histone H4 lysine during development of in vitro fertilized, cloned and parthenogenetically activated bovine embryos. Epigenetics, 3(4), 199-209. https://doi.org/10.4161/epi.3.4.6497

The oocyte is remarkable in its ability to remodel parental genomes following fertilization and to reprogram somatic nuclei after nuclear transfer (NT). To characterize the patterns of histone H4 acetylation and DNA methylation during development of... Read More about Differential acetylation of histone H4 lysine during development of in vitro fertilized, cloned and parthenogenetically activated bovine embryos.

Panel discussion [of paper: Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat] (2008)
Journal Article
Ivell, R., Hass, U., Anand-Ivell, R., & Gray, E. (2008). Panel discussion [of paper: Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat]. International Journal of Andrology, 31(2), 247-248. https://doi.org/10.1111/j.1365-2605.2008.00866.x

This is a panel discussion of: Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat / S. Christiansen, M. Scholze, M. Axelstad, J. Boberg, A. Kortenkamp, U. Hass. Summary of main paper: The incidence... Read More about Panel discussion [of paper: Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat].

Identification of a broadly cross-reacting and neutralizing human monoclonal antibody directed against the hepatitis C virus E2 protein (2008)
Journal Article
Perotti, M., Mancini, N., Diotti, R. A., Tarr, A. W., Ball, J. K., Owsianka, A., …Burioni, R. (2008). Identification of a broadly cross-reacting and neutralizing human monoclonal antibody directed against the hepatitis C virus E2 protein. Journal of Virology, 82(2), 1047-1052. https://doi.org/10.1128/JVI.01986-07

Identification of anti-hepatitis C virus (anti-HCV) human antibody clones with broad neutralizing activity is important for a better understanding of the interplay between the virus and host and for the design of an effective passive immunotherapy an... Read More about Identification of a broadly cross-reacting and neutralizing human monoclonal antibody directed against the hepatitis C virus E2 protein.

New insights into the internationalization of producer services: Organizational strategies and spatial economies for global headhunting firms (2008)
Journal Article
Faulconbridge, J. R., Hall, S. J., & Beaverstock, J. V. (2008). New insights into the internationalization of producer services: Organizational strategies and spatial economies for global headhunting firms. Environment and Planning A, 40(1), 210-234. https://doi.org/10.1068/a3924

This paper uses the exemplar of global headhunting firms to provide new insights into the intricacies of internationalization and related 'spatial economies' of producer services in the world economy. In particular, we unpack the complex relationship... Read More about New insights into the internationalization of producer services: Organizational strategies and spatial economies for global headhunting firms.

Influencing organisational change in the NHS: lessons learned from workplace wellness initiatives in practice (2008)
Journal Article
Blake, H., & Lloyd, S. (2007). Influencing organisational change in the NHS: lessons learned from workplace wellness initiatives in practice. Quality in Primary Care, 16(6), (449-455). ISSN 1479-1072

This article presents a discussion of the key issues in influencing organisational change in NHS settings, in the development of workplace wellness interventions to improve employee health and wellbeing. To tackle poor public health and associated ri... Read More about Influencing organisational change in the NHS: lessons learned from workplace wellness initiatives in practice.

A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection (2008)
Journal Article
Abedin, A., Mohammed, I., Hopkinson, A., & Dua, H. S. (2008). A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection. Investigative Ophthalmology & Visual Science, 49(1), (28-33). doi:10.1167/iovs.07-0645. ISSN 1552-5783

PURPOSE: Antimicrobial peptides (AMPs) are cationic host defense peptides with microbicidal and cell-signaling properties. They show promise as potential therapeutic agents. In the present study, a beta-defensin AMP gene was isolated from the ocular... Read More about A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection.

The Motif Tracking Algorithm (2008)
Journal Article
Wilson, W., Birkin, P., & Aickelin, U. (2008). The Motif Tracking Algorithm. International Journal of Automation and Computing, 5(January), 32–44

The search for patterns or motifs in data represents a problem area of key interest to finance and economic researchers. In this paper we introduce the Motif Tracking Algorithm, a novel immune inspired pattern identification tool that is able to iden... Read More about The Motif Tracking Algorithm.

The effect of laser transformation notching on the controlled fracture of a high carbon (C70S6 ) steel (2008)
Journal Article
Zhang, D., Harris, S. J., McCartney, D., Pashby, I., Powell, J., Shipway, P., & Voisey, K. (2008). The effect of laser transformation notching on the controlled fracture of a high carbon (C70S6 ) steel. Materials Science and Engineering: A, 489(1-2), https://doi.org/10.1016/j.msea.2007.12.040

A high carbon (C70S6) steel has been laser surface treated using CO2 and Diode lasers in order to produce an embrittled region to act as a fracture notch. Such a process has been investigated as a precursor to the fracture splitting of automotive eng... Read More about The effect of laser transformation notching on the controlled fracture of a high carbon (C70S6 ) steel.

Dum (assombrado) complexo de Bartleby: Isto [não] é um livro e eu [não] sou daqui (ou da [im]possibilidade lusófona da Galiza) (2008)
Journal Article
Vidal Bouzon, Á. J. (2008). Dum (assombrado) complexo de Bartleby: Isto [não] é um livro e eu [não] sou daqui (ou da [im]possibilidade lusófona da Galiza)

In 2003 the Galizan writer João Guisan published Isto é um livro. Projecto Dicionário Vivo, conceived as ‘a project of a Project’ which would retain an essential relationship with language and writing but would potentially exceed them, crossing the b... Read More about Dum (assombrado) complexo de Bartleby: Isto [não] é um livro e eu [não] sou daqui (ou da [im]possibilidade lusófona da Galiza).

Resettlement and reintegration: single mothers' reflections after homelessness (2008)
Journal Article
Tischler, V. (2008). Resettlement and reintegration: single mothers' reflections after homelessness. Community, Work and Family, 11(3), https://doi.org/10.1080/13668800802133628

Previous research has identified that most families who become homeless are women with dependent children. Homeless families are reported to have a variety of complex needs however little is known about the experiences of families once they are re-ho... Read More about Resettlement and reintegration: single mothers' reflections after homelessness.

Isotope offsets in marine diatom ?18O over the last 200 ka (2008)
Journal Article
Swann, G. E., Leng, M. J., Sloane, H. J., & Maslin, M. A. (2008). Isotope offsets in marine diatom ?18O over the last 200 ka. Journal of Quaternary Science, 23(4), https://doi.org/10.1002/jqs.1185

Previous work has suggested that a species effect may be present in diatom oxygen isotope ratios (δ18Odiatom). While predominantly attributed to be a size related species effect, currently the precise mechanism remains unknown. Here, two size fractio... Read More about Isotope offsets in marine diatom ?18O over the last 200 ka.

Ambivalent improvements: biography, biopolitics, and colonial Delhi (2008)
Journal Article
Stephen, L. (2008). Ambivalent improvements: biography, biopolitics, and colonial Delhi. Environment and Planning A, 40(1), https://doi.org/10.1068/a38460

This paper explores the ambivalent feelings towards the Government of India produced in one of the government’s own employees. In establishing the Delhi Improvement Trust in the 1930s, Arthur Parke Hume had to battle against governmental cost cutting... Read More about Ambivalent improvements: biography, biopolitics, and colonial Delhi.