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All Outputs (225)

Effect of maternal dietary restriction during pregnancy on lamb carcass characteristics and muscle fiber composition (2007)
Journal Article

Two experiments were conducted to determine whether the decreased proportion of fast muscle fibers seen previously in 2-wk-old lambs from ewes that were dietary restricted from d 30 to 70 of gestation are still evident in older lambs and what the con... Read More about Effect of maternal dietary restriction during pregnancy on lamb carcass characteristics and muscle fiber composition.

Critical Psychiatry (2007)
Journal Article

Critical psychiatry appraises and comments upon psychiatric services as they are usually provided. This article, prompted by the publication of a recent book, considers the place of critical psychiatry historically and in the context of contemporar... Read More about Critical Psychiatry.

National evaluation of NHS genetics service investments: emerging issues from the cancer genetics pilots (2007)
Journal Article

In seeking to fulfil the ambition of the 2003 genetics white paper, Our Inheritance, Our Future, to ‘mainstream’ genetic knowledge and practices, the Department of Health provided start-up funding for pilot services in various clinical areas, includi... Read More about National evaluation of NHS genetics service investments: emerging issues from the cancer genetics pilots.

A Utilitarian Perspective of Social and Medical Contributions to Three Illustrative Conditions, and Recent UK NHS Policy Initiatives (2007)
Journal Article

Background: To date debate concerning the relative merits of social and medical sciences has been largely academic. Aims: To outline and critically appraise a utilitarian approach to mental health research that reflects a critical realist perspect... Read More about A Utilitarian Perspective of Social and Medical Contributions to Three Illustrative Conditions, and Recent UK NHS Policy Initiatives.

Randomized controlled trial of the intraligamental use of a local anaesthetic (lignocaine 2%) versus controls in paediatric tooth extraction (2007)
Journal Article

Background. Children still experience pain upon waking following dental extraction under general anaesthesia. Local anaesthetic has been shown to reduce this pain, but needs to be administered via a method that causes minimum injury or distress to th... Read More about Randomized controlled trial of the intraligamental use of a local anaesthetic (lignocaine 2%) versus controls in paediatric tooth extraction.

Systemic administration of the benzodiazepine receptor partial inverse agonist FG-7142 disrupts corticolimbic network interactions (2007)
Journal Article

The medial prefrontal cortex (mPFC) and basolateral amygdala(BLA) coordinate various stress responses. Although the effects of stressors on mPFCand BLA activity have been previously examined, it remains unclear to what extent stressors affect functio... Read More about Systemic administration of the benzodiazepine receptor partial inverse agonist FG-7142 disrupts corticolimbic network interactions.

The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in rats (2007)
Journal Article

This study assessed whether dopamine in the dorsomedial striatum is necessary for flexible adaptation to changes in stimulus–response contingencies. As KW-6002 (Istradefylline), an adenosine A2A antagonist, improves motor deficits resulting from stri... Read More about The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in rats.

Can we improve the statistical analysis of stroke trials? Statistical re-analysis of functional outcomes in stroke trials (2007)
Journal Article

Background and Purpose—Most large acute stroke trials have been neutral. Functional outcome is usually analyzed usinga yes or no answer, eg, death or dependency versus independence. We assessed which statistical approaches are mostefficient in analyz... Read More about Can we improve the statistical analysis of stroke trials? Statistical re-analysis of functional outcomes in stroke trials.

Protean agonism at the dopamine D2 receptor: (S)-3-(3-hydroxyphenyl)-N-propylpiperidine is an agonist for activation of Go1 but an antagonist/inverse agonist for Gi1,Gi2, and Gi3 (2007)
Journal Article

A range of ligands displayed agonism at the long isoform of the human dopamine D(2) receptor, whether using receptor-G protein fusions or membranes of cells in which pertussis toxin-resistant mutants of individual Galpha(i)-family G proteins could be... Read More about Protean agonism at the dopamine D2 receptor: (S)-3-(3-hydroxyphenyl)-N-propylpiperidine is an agonist for activation of Go1 but an antagonist/inverse agonist for Gi1,Gi2, and Gi3.