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The Virtual International Stroke Trials Archive

Myzoon, Ali; Bath, Philip M.W.; Curram, John; Davis, Stephen M.; Diener, Hans-Christoph; Donnan, Geoffrey A.; Fisher, Marc; Gregson, Barbara A.; Grotta, James; Hacke, Werner; Hennerici, Michael G.; Hommel, Marc; Kaste, Markku; Marler, John R.; Sacco, Ralph L.; Teal, Philip; Wahlgren, Nils-Gunnar; Warach, Steven; Weir, Christopher J.; Lees, Kennedy R.

Authors

Ali Myzoon

Philip M.W. Bath

John Curram

Stephen M. Davis

Hans-Christoph Diener

Geoffrey A. Donnan

Marc Fisher

Barbara A. Gregson

James Grotta

Werner Hacke

Michael G. Hennerici

Marc Hommel

Markku Kaste

John R. Marler

Ralph L. Sacco

Philip Teal

Nils-Gunnar Wahlgren

Steven Warach

Christopher J. Weir

Kennedy R. Lees

Abstract

Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and
economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs
highlights the need for reliable data on which to plan future clinical trials. The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses.
Methods - Data were contributed by the principal investigators of numerous trials from the past 16 years. These data have been centrally collated and are available for anonymized analysis and hypothesis testing.
Results - ”Currently, the Virtual International Stroke Trials Archive contains 21 trials. There are data on 15 000 patients with both ischemic and hemorrhagic stroke. Ages range between 18 and 103 years, with a mean age of 6912 years. Outcome measures include the Barthel Index, Scandinavian Stroke Scale, National Institutes of Health Stroke Scale, Orgogozo Scale, and modified Rankin Scale. Medical history and onset-to-treatment time are readily available, and computed tomography lesion data are available for selected trials.
Conclusions - This resource has the potential to influence clinical trial design and implementation through data analyses that inform planning. (Stroke. 2007;38:1905-1910.)

Journal Article Type Article
Publication Date Jun 1, 2007
Journal Stroke
Print ISSN 0039-2499
Publisher American Heart Association
Peer Reviewed Peer Reviewed
Volume 38
Issue 6
Institution Citation Myzoon, A., Bath, P. M., Curram, J., Davis, S. M., Diener, H., Donnan, G. A., …Lees, K. R. (2007). The Virtual International Stroke Trials Archive. Stroke, 38(6),
Keywords clinical trials trial design natural history database modified Rankin Scale
National Institutes of Health Stroke Scale
Related Public URLs http://stroke.ahajournals.org/
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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