All Outputs (206)

A systematic review and narrative synthesis exploring the relationship between friendships and peer relationships, and self-harm ideation and behaviour among young people (2024)
Working Paper

Friendships and peer relationships have an important role in the experience of self-harm ideation and behaviour in young people, yet they typically remain overlooked. The present systematic review and narrative synthesis explore the extant literature... Read More about A systematic review and narrative synthesis exploring the relationship between friendships and peer relationships, and self-harm ideation and behaviour among young people.

A protocol to assess risk of fractures associated with use of menopausal hormone therapy: nested case-control study using CPRD (2024)
Working Paper

Menopausal hormone therapy (MHT) is prescribed to women with severe symptoms of menopause. Various studies have demonstrated increased bone density and decreased fracture risk in women using MHT. The randomised controlled trials were, however, run ov... Read More about A protocol to assess risk of fractures associated with use of menopausal hormone therapy: nested case-control study using CPRD.

Reinforcement learning when your life depends on it: a neuro-economic theory of learning (2024)
Working Paper

Synaptic plasticity enables animals to adapt to their environment, but memory formation can consume a substantial amount of metabolic energy, potentially impairing survival. Hence, a neuro-economic dilemma arises whether learning is a profitable inve... Read More about Reinforcement learning when your life depends on it: a neuro-economic theory of learning.

Peer-Reviews and AI Feedback Compared: University Students’ Preferences (2024)
Working Paper

This article seeks to contribute to the existing literature on peer review by comparing human with machine reviews based on the implementation of a chatbot responding with reference to a large language model for the review of open-ended student work.... Read More about Peer-Reviews and AI Feedback Compared: University Students’ Preferences.

Open and closed conformations of a sub-80 kDa Chagas vaccine candidate defined by a cryo-EM led integrative approach (2024)
Working Paper

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, remains a significant global public health concern. It affects an estimated eight million individuals worldwide, with the majority remaining undiagnosed. Despite its profound health... Read More about Open and closed conformations of a sub-80 kDa Chagas vaccine candidate defined by a cryo-EM led integrative approach.

Characterising the stimulus-response function of mouse C-Low threshold mechanoreceptors to mechanical stimuliin vivo (2024)
Working Paper

C-low threshold mechanoreceptors (C-LTMRs) in animals (termed C-tactile (CT) fibres in humans) are a subgroup of C-fibre primary afferents, which innervate hairy skin and respond to low threshold punctate indentations and brush stimuli. These afferen... Read More about Characterising the stimulus-response function of mouse C-Low threshold mechanoreceptors to mechanical stimuliin vivo.

Non-Consensual Sex among Japanese Women in the COVID-19 Pandemic: A Large-Scale Nationwide Survey-Based Study (2024)
Working Paper

Background: Non-consensual sex including rape and sexual assault has been a global concern and may have been influenced by the COVID-19 pandemic, however the information on this topic is limited. Therefore, our objective was to survey the incidence r... Read More about Non-Consensual Sex among Japanese Women in the COVID-19 Pandemic: A Large-Scale Nationwide Survey-Based Study.

Direct Deposition of Copper Atoms onto Graphitic Step Edges Lowers Overpotential and Improves Selectivity of Electrocatalytic CO2 Reduction (2024)
Working Paper

Minimizing our reliance on bulk precious metals is to increase the fraction of surface atoms and improve the metal-support interface. In this work, we employ a solvent/ligand/counterion-free method to deposit copper in the atomic form directly onto a... Read More about Direct Deposition of Copper Atoms onto Graphitic Step Edges Lowers Overpotential and Improves Selectivity of Electrocatalytic CO2 Reduction.

Assessing spontaneous sensory neuron activity usingin vivocalcium imaging (2024)
Working Paper

Heightened spontaneous activity in sensory neurons is often reported in individuals living with chronic pain. It is possible to study this activity in rodents using electrophysiology, but these experiments require great skill and can be prone to bias... Read More about Assessing spontaneous sensory neuron activity usingin vivocalcium imaging.

Author Response: Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet (2024)
Working Paper

Seedling root traits impact plant establishment under challenging environments. Pearl millet is one of the most heat and drought tolerant cereal crops that provides a vital food source across the sub-Saharan Sahel region. Pearl millet’s early root sy... Read More about Author Response: Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet.

A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom (2024)
Working Paper

Background To explore how a vocational rehabilitation (VR) intervention can be integrated within existing healthcare services for people with multiple sclerosis (MS) in the United Kingdom (UK) National Health Service (NHS). Methods Data from 37... Read More about A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom.

Conofolidine, a Natural Plant Alkaloid Causes Apoptosis and Senescence in Cancer Cells (2024)
Working Paper

Natural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel Aspidosperma-Aspidosperma bisindole alkaloid isolated from the Malayan plant Tabernaemontana corymbo... Read More about Conofolidine, a Natural Plant Alkaloid Causes Apoptosis and Senescence in Cancer Cells.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2023)
Working Paper

Background Sulfasalazine induced cytopenia, nephrotoxicity, and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend three monthly monitoring blood-tests indefinitely while others recommend stopping monitoring after one ye... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial (2023)
Working Paper

The study aimed to investigate the effect of climate change exposure on affect and pro-environmental behavioural intentions in a randomised controlled trial. An online survey was completed by 100 adult participants and included measures of affect and... Read More about Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial.

Origins of polysaccharide conformation and viscoelasticity in miscible heterogeneous solvent (2023)
Working Paper

A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2 (2023)
Working Paper

The human ATP-binding cassette (ABC) transporter, ABCG2 is responsible for multidrug resistance in some tumours. Detailed knowledge of its activity is crucial for understanding drug transport and resistance in cancer, and has implications for wider p... Read More about A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2.

Understanding public perceptions of virtual reality psychological therapy: development of the attitudes towards virtual reality therapy (AVRT) Scale (Preprint) (2023)
Working Paper

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases (2023)
Working Paper

Aging is a major driving force for many diseases but the relationship between age, aging processes and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related... Read More about Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

Progress in lignocellulosic biomass valorization for biofuels and value‐added chemical production in the EU: A focus on thermochemical conversion processes (2023)
Working Paper

The demand for sustainable energy sources has increased owing to environmental concerns, such as climate change, rising energy demand and rapid industrialization. Biomass utilization for bioenergy and value‐added chemical production has become essent... Read More about Progress in lignocellulosic biomass valorization for biofuels and value‐added chemical production in the EU: A focus on thermochemical conversion processes.

Beyond the Bedside: Protocol for a scoping review exploring the experiences of non-practicing healthcare professionals within health professions education (2023)
Working Paper

Background: The number of healthcare professionals leaving clinical practice and transitioning to alternative careers in health professions education is increasing. Among these non-practicing healthcare professionals, concerns have been reported rega... Read More about Beyond the Bedside: Protocol for a scoping review exploring the experiences of non-practicing healthcare professionals within health professions education.