All Outputs (210)

Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports (2023)
Working Paper

Injury to the proximal part of the equine suspensory ligament (SL), called proximal suspensory desmitis (PSD), commonly causes lameness in horses. PSD is extremely difficult to manage and treat, with present methods often unable to achieve full recov... Read More about Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports.

Differences between online trial participants who have used statutory mental health services and who have not: analysis of baseline data from two pragmatic trials of a digital health intervention (2023)
Working Paper

Background: Digital health interventions have become an established part of mental health service provision internationally. Regulators have positioned the best-practice standard of evidence as an interventional study with a comparator reflective of... Read More about Differences between online trial participants who have used statutory mental health services and who have not: analysis of baseline data from two pragmatic trials of a digital health intervention.

Next-generation sequencing of pancreatic cyst wall specimens obtained using Moray micro-forceps for improving diagnostic accuracy (2023)
Working Paper

Background and study aims Pancreatic cysts are common incidental findings, with an estimated prevalence of 13-15% in imaging done for other reasons. It is difficult to identify cysts with malignant potential. Diagnosis often relies on collection of c... Read More about Next-generation sequencing of pancreatic cyst wall specimens obtained using Moray micro-forceps for improving diagnostic accuracy.

Pathways for the Valorization of Animal and Human Waste to Biofuels, Sustainable Materials and Value-Added Chemicals (2023)
Working Paper

Human and animal waste, including waste products originating from human or animal digestive systems such as urine, feces, and animal manure, have constituted a nuisance to the environment. Inappropriate disposal and poor sanitation of human and anima... Read More about Pathways for the Valorization of Animal and Human Waste to Biofuels, Sustainable Materials and Value-Added Chemicals.

Assessing changes in global fire regimes (2023)
Working Paper

Human activity has fundamentally altered wildfire on Earth, creating serious consequences for human health, global biodiversity, and climate change. However, it remains difficult to predict fire interactions with land use, management, and climate cha... Read More about Assessing changes in global fire regimes.

The influence of heteroresistance on minimum inhibitory concentration (MIC), investigated using weak-acid stress in food spoilage yeasts (2023)
Working Paper

Populations of microbial cells may resist environmental stress by maintaining a high population-median resistance (IC50) or, potentially, a high variability in resistance between individual cells (heteroresistance); where heteroresistance would allow... Read More about The influence of heteroresistance on minimum inhibitory concentration (MIC), investigated using weak-acid stress in food spoilage yeasts.

The biocide triclosan induces (p)ppGpp dependent antibiotic tolerance and alters SarA dependent biofilm structures in Staphylococcus aureus (2023)
Working Paper

The biocide triclosan is used extensively in both household and hospital settings. The chronic exposure to the biocide occurring in individuals that use triclosan-containing products results in low levels of triclosan present in the human body that h... Read More about The biocide triclosan induces (p)ppGpp dependent antibiotic tolerance and alters SarA dependent biofilm structures in Staphylococcus aureus.

AI4Green: An Open-Source ELN for Green and Sustainable Chemistry (2023)
Working Paper

An Electronic Laboratory Notebook (ELN) combining features, including data archival, collaboration tools, and green and sustainability metrics for organic chemistry, is presented. AI4Green is a web-based application, available as open-source code and... Read More about AI4Green: An Open-Source ELN for Green and Sustainable Chemistry.

Sustainability of Bioenergy – Mapping the Risks & Benefits to Inform Future Bioenergy Systems (2023)
Working Paper

Bioenergy is widely included in energy strategies for its GHG mitigation potential. Bioenergy technologies will likely have to be deployed at scale to meet decarbonisation targets, and consequently biomass will have to be increasingly grown/mobilised... Read More about Sustainability of Bioenergy – Mapping the Risks & Benefits to Inform Future Bioenergy Systems.

OptoRheo: Simultaneous in situ micro-mechanical sensing and 3D imaging of live cell cultures (2023)
Working Paper

Biomechanical cues from the extracellular matrix (ECM) are essential for directing many cellular processes, from normal development and repair, to disease progression. To better understand cell-matrix interactions, we have developed a new instrument... Read More about OptoRheo: Simultaneous in situ micro-mechanical sensing and 3D imaging of live cell cultures.

Estimating the energy requirements for long term memory formation (2023)
Working Paper

Brains consume metabolic energy to process information, but also to store memories. The energy required for memory formation can be substantial, for instance in fruit flies memory formation leads to a shorter lifespan upon subsequent starvation (Mery... Read More about Estimating the energy requirements for long term memory formation.

Patient and Public Involvement and Engagement for PhD Students (2023)
Working Paper

This paper aims to provide useful advice regarding the development of skills for patient and public involvement and engagement (PPIE) in research. The authors of this paper comprise experienced PhD supervisors and trainers, researchers leading PPIE a... Read More about Patient and Public Involvement and Engagement for PhD Students.

Establishment of a novel set of vectors for transformation of the dinoflagellate Amphidinium carterae (2022)
Working Paper

Peridinin-containing dinoflagellate algae have a chloroplast genome formed from plasmid-like minicircles. This fragmented genome has allowed us to develop a genetic modification methodology involving the use of biolistics to introduce artificial mini... Read More about Establishment of a novel set of vectors for transformation of the dinoflagellate Amphidinium carterae.

The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation: a prospective multi-centre cohort study (2022)
Working Paper

The protective role of staff wellbeing centres for wellbeing and presenteeism in healthcare workers during the COVID-19 pandemic: Secondary analysis of COVID-Well data (2022)
Working Paper

Background Supported wellbeing centres established during the COVID-19 pandemic provided high quality rest spaces and access to peer-to-peer psychological first aid for healthcare workers (HCWs). The centres were well accessed and valued by HCWs,... Read More about The protective role of staff wellbeing centres for wellbeing and presenteeism in healthcare workers during the COVID-19 pandemic: Secondary analysis of COVID-Well data.

GPT4 : The Ultimate Brain (2022)
Working Paper

We introduce a powerful general probabilistic theory, GPT4, that extends classical and quantum theories to include higher-dimensional probabilistic models. GPT4 results from the four-fold integration of GPT in physics (Generalized Probabilistic T... Read More about GPT4 : The Ultimate Brain.

Modified bronchoscopy masks mitigate aerosols during gastroscopies (2022)
Working Paper

Digestive endoscopy has been proven to produce aerosols (1–3). This represents a risk of infection by COVID-19 and other airborne viruses. A number of protective barriers have been proposed to minimise that risk. Continuous suction of the oral cavity... Read More about Modified bronchoscopy masks mitigate aerosols during gastroscopies.

Assessing diversity and inclusivity is the next frontier in mental health recovery narrative research and practice (Preprint) (2022)
Working Paper

Demand for digital health interventions is increasing in many countries. The use of recorded mental health recovery narratives in digital health interventions is becoming more widespread in clinical practice. Mental health recovery narratives are fir... Read More about Assessing diversity and inclusivity is the next frontier in mental health recovery narrative research and practice (Preprint).

Solutions to Hazardous Wastes Issues in the Leather Industry: Adsorption of Chromium Iii and Vi from Leather Industry Wastewaters Using Activated Carbons Produced from Leather Industry Solid Wastes (2022)
Working Paper

This study presents the use of an innovative material to tackle hazardous wastes in the leather industry. Activated carbons produced from Leather industry waste (LIW) were used to adsorb Chromium (Cr) III and (VI), which are found in leather wastewa... Read More about Solutions to Hazardous Wastes Issues in the Leather Industry: Adsorption of Chromium Iii and Vi from Leather Industry Wastewaters Using Activated Carbons Produced from Leather Industry Solid Wastes.

Feasibility and Acceptability of an Internet of Things–Enabled Sedentary Behavior Intervention: Mixed Methods Study (Preprint) (2022)
Working Paper

Background: Encouraging office workers to break up prolonged sedentary behavior (SB) at work with regular micro-breaks can be beneficial yet challenging. Internet of Things (IoT) offers great promise for delivering more subtle and hence acceptable b... Read More about Feasibility and Acceptability of an Internet of Things–Enabled Sedentary Behavior Intervention: Mixed Methods Study (Preprint).