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Large neighbourhood search with adaptive guided ejection search for the pickup and delivery problem with time windows (2018)
Journal Article

© 2018, The Author(s). An effective and fast hybrid metaheuristic is proposed for solving the pickup and delivery problem with time windows. The proposed approach combines local search, large neighbourhood search and guided ejection search in a novel... Read More about Large neighbourhood search with adaptive guided ejection search for the pickup and delivery problem with time windows.

Growing up in a megalopolis: environmental effects on galaxy evolution in a supercluster at z?0.65 in UKIDSS UDS (2018)
Journal Article

We present a large-scale galaxy structure Cl J021734-0513 at z ∼ 0.65 discovered in the UKIDSS UDS field, made of ∼ 20 galaxy groups and clusters, spreading over 10 Mpc. We report on a VLT/VIMOS spectroscopic follow-up program that, combined with pas... Read More about Growing up in a megalopolis: environmental effects on galaxy evolution in a supercluster at z?0.65 in UKIDSS UDS.

Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24–48 h after exercise in young and old humans (2018)
Journal Article

The molecular and metabolic mechanisms underlying the increase in insulin sensitivity (i.e. increased insulin-stimulated skeletal muscle glucose uptake, phosphorylation and storage as glycogen) observed from 12 to 48 h following a single bout of exer... Read More about Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24–48 h after exercise in young and old humans.

Virtual genome walking across the 32 Gb Ambystoma mexicanum genome; assembling gene models and intronic sequence (2018)
Journal Article

Large repeat rich genomes present challenges for assembly using short read technologies. The 32 Gb axolotl genome is estimated to contain ~19 Gb of repetitive DNA making an assembly from short reads alone effectively impossible. Indeed, this model sp... Read More about Virtual genome walking across the 32 Gb Ambystoma mexicanum genome; assembling gene models and intronic sequence.

Views and experiences of seeking information and help for vitiligo: a qualitative study of written accounts (2018)
Journal Article

Objectives: Vitiligo is a relatively common autoimmune condition causing loss of skin pigment. Around 1 in 100 people in the UK develop vitiligo. It can have a significant impact on quality of life for many of those affected. How people access inform... Read More about Views and experiences of seeking information and help for vitiligo: a qualitative study of written accounts.

Microstructure and properties of C/C–ZrC composites prepared by hydrothermal deposition combined with carbothermal reduction (2018)
Journal Article

Carbon fiber reinforced carbon matrix containing ZrC (C/C–ZrC) composites were prepared by hydrothermal deposition combined with carbothermal reduction. The submicron ZrC particles (100~300 nm) were dispersed in the matrix. The stress-strain curves o... Read More about Microstructure and properties of C/C–ZrC composites prepared by hydrothermal deposition combined with carbothermal reduction.

Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria (2018)
Journal Article

Mitochondrial Ca2+ homoeostasis regulates aerobic metabolism and cell survival. Ca2+ flux into mitochondria is mediated by the mitochondrial calcium uniporter (MCU) channel whereas Ca2+ export is often through an electrogenic Na+–Ca2+ exchanger. Here... Read More about Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria.

Analysis of intercomponent energy transfer in the interaction of oscillating-grid turbulence with an impermeable boundary (2018)
Journal Article

New experimental results are presented that investigate the nature of the intercomponent energy transfer that occurs in the interaction between oscillating-grid turbulence and a solid impermeable boundary, using instantaneous velocity measurements ob... Read More about Analysis of intercomponent energy transfer in the interaction of oscillating-grid turbulence with an impermeable boundary.

Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery (2018)
Journal Article

A robust discovery methodology is presented to identify novel biomaterials suitable for 3D printing. Currently the application of Additive Manufacturing is limited by the availability of functional inks, especially in the area of biomaterials-this me... Read More about Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery.

A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort (2018)
Journal Article

Objectives: Cognitive deficits are a common feature of neuropsychiatric disorders. We investigated the relationship between cognitive performance and a deletion allele within GluK4 protective against risk for bipolar disorder, in 1642 individuals fro... Read More about A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort.