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A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort

Koromina, Maria; Flitton, Miles; Mellor, Ian R.; Knight, Helen M.

Authors

Maria Koromina

Miles Flitton

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IAN MELLOR IAN.MELLOR@NOTTINGHAM.AC.UK
Assistant Professor



Abstract

Objectives: Cognitive deficits are a common feature of neuropsychiatric disorders. We investigated the relationship between cognitive performance and a deletion allele within GluK4 protective against risk for bipolar disorder, in 1642 individuals from the TwinsUK study.
Methods: Cognitive performance was assessed using the National Adult Reading Test, four CANTAB tests (Spatial Working Memory, Paired Associates Learning, Pattern Recognition Memory, and Reaction Time), and two Principal Component Analysis derived factors. Performance in individuals homozygous for the insertion allele was compared to deletion carriers and analysis was adjusted for age of diagnosis, medication and clinical diagnosis.
Results: Individuals with the GluK4 protective deletion allele performed significantly better in Spatial Working Memory compared to insertion homozygotes when adjusted for a clinical diagnosis. GluK4 deletion carriers who had a mental health problem (predominately depression) showed better performance in visuo-spatial ability and mental processing speed compared to individuals with mental health problems homozygous for the insertion.
Conclusions: These findings of genotype-dependent cognitive enhancement across clinical groups support the potential clinical use of the GluK4 deletion allele in personalized medicine strategies and provide new insight into the relationship between genetic variation and mood disorders.

Citation

Koromina, M., Flitton, M., Mellor, I. R., & Knight, H. M. (2019). A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort. World Journal of Biological Psychiatry, 20(5), 393-401. https://doi.org/10.1080/15622975.2017.1417637

Journal Article Type Article
Acceptance Date Dec 12, 2017
Online Publication Date Jan 11, 2018
Publication Date 2019
Deposit Date Dec 15, 2017
Publicly Available Date Mar 28, 2024
Journal World Journal of Biological Psychiatry
Print ISSN 1562-2975
Electronic ISSN 1814-1412
Publisher Taylor and Francis
Peer Reviewed Peer Reviewed
Volume 20
Issue 5
Pages 393-401
DOI https://doi.org/10.1080/15622975.2017.1417637
Keywords Kainate receptors, GluK4, deletion allele, cognition, mood disorders
Public URL https://nottingham-repository.worktribe.com/output/903989
Publisher URL http://www.tandfonline.com/doi/abs/10.1080/15622975.2017.1417637
Additional Information This is an Accepted Manuscript of an article published by Taylor & Francis in World Journal of Biological Psychiatry on January 1 2018, available online: http://www.tandfonline.com/10.1080/15622975.2017.1417637

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