A two-directional approach to pyrrolizidines: total syntheses and biological evaluation of alkaloid cis-223B and (+/-)-xenovenine

Barthelme, Alexandre; Richards, David; Mellor, Ian R.; Stockman, Robert A.

Abstract

Total syntheses of alkaloid cis-223B and xenovenine are reported in 3 and 4 steps respectively using a two-directional synthesis/triple reductive amination strategy, and their neurotoxic properties assessed.

Citation

Barthelme, A., Richards, D., Mellor, I. R., & Stockman, R. A. (2013). A two-directional approach to pyrrolizidines: total syntheses and biological evaluation of alkaloid cis-223B and (+/-)-xenovenine. Chemical Communications, 49(89), https://doi.org/10.1039/c3cc46800c

• Journal Article Type: Article
• Acceptance Date: Sep 27, 2013
• Online Publication Date: Sep 27, 2013
• Publication Date: Nov 18, 2013
• Deposit Date: Jul 25, 2016
• Publicly Available Date: Jul 25, 2016
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 49
• Issue: 89
• DOI: https://doi.org/10.1039/c3cc46800c
• Public URL: https://nottingham-repository.worktribe.com/output/719319
• Publisher URL: http://pubs.rsc.org/en/Content/ArticleLanding/2013/CC/c3cc46800c#!divAbstract
• Contract Date: Jul 25, 2016