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An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids

Amey, Joanna S.; O'Reilly, Andrias O.; Burton, Mark J.; Puinean, Alin M.; Mellor, Ian R.; Duce, Ian R.; Field, Linda M.; Wallace, B.A.; Williamson, Martin S.; Davies, T.G. Emyr

Authors

Joanna S. Amey

Andrias O. O'Reilly

Mark J. Burton

Alin M. Puinean

IAN MELLOR ian.mellor@nottingham.ac.uk
Assistant Professor

Ian R. Duce

Linda M. Field

B.A. Wallace

Martin S. Williamson

T.G. Emyr Davies



Abstract

We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin. We demonstrate that this channel has most likely arisen by adaptation (gene fission or duplication) of an invertebrate ancestral mono(hetero)meric channel. This is the only identifiable voltage-gated sodium channel homologue in the aphid genome(s), and the channel's novel selectivity filter motif (DENS instead of the usual DEKA found in other eukaryotes) may result in a loss of sodium selectivity, as indicated experimentally in mutagenised Drosophila channels.

Citation

Amey, J. S., O'Reilly, A. O., Burton, M. J., Puinean, A. M., Mellor, I. R., Duce, I. R., …Davies, T. E. (2015). An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids. FEBS Letters, 589(5), 598-607. https://doi.org/10.1016/j.febslet.2015.01.020

Journal Article Type Article
Acceptance Date Jan 5, 2015
Online Publication Date Jan 27, 2015
Publication Date Feb 27, 2015
Deposit Date Jul 15, 2016
Publicly Available Date Jul 15, 2016
Journal FEBS Letters
Print ISSN 0014-5793
Electronic ISSN 1873-3468
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 589
Issue 5
Pages 598-607
DOI https://doi.org/10.1016/j.febslet.2015.01.020
Keywords Voltage-gated sodium channel, Aphid, Evolution, Tetrodotoxin
Public URL http://eprints.nottingham.ac.uk/id/eprint/34979
Publisher URL http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.01.020/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
Additional Information This article is maintained by: Elsevier; Article Title: An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids; Journal Title: FEBS Letters; CrossRef DOI link to publisher maintained version: http://dx.doi.org/10.1016/j.febslet.2015.01.020; Content Type: article; Copyright: Copyright © 2015 The Authors. Published by Elsevier B.V.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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