Skip to main content

Research Repository

Advanced Search

Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery

Louzao, Iria; Koch, Britta; Taresco, Vincenzo; Ruiz Cantu, Laura; Irvine, Derek J.; Roberts, Clive J.; Tuck, Christopher J.; Alexander, Cameron; Hague, Richard J.M.; Wildman, Ricky D.; Alexander, Morgan R.

Authors

Iria Louzao

Britta Koch

Laura Ruiz Cantu

DEREK IRVINE derek.irvine@nottingham.ac.uk
Professor of Materials Chemistry

CHRISTOPHER TUCK CHRISTOPHER.TUCK@NOTTINGHAM.AC.UK
Professor of Materials Engineering

RICHARD HAGUE RICHARD.HAGUE@NOTTINGHAM.AC.UK
Professor of Additive Manufacturing

RICKY WILDMAN RICKY.WILDMAN@NOTTINGHAM.AC.UK
Professor of Multiphase Flow and Mechanics

Profile Image

MORGAN ALEXANDER MORGAN.ALEXANDER@NOTTINGHAM.AC.UK
Professor of Biomedical Surfaces



Abstract

A robust discovery methodology is presented to identify novel biomaterials suitable for 3D printing. Currently the application of Additive Manufacturing is limited by the availability of functional inks, especially in the area of biomaterials-this method tackles this problem for the first time allowing hundreds of formulations to be readily assessed. Several functional properties, including the release of an antidepressive drug (paroxetine), cytotoxicity and printability are screened for 253 new ink formulations in a high-throughput format as well as mechanical properties. The selected candidates with the desirable properties are successfully scaled up using 3D printing into a range of objects architectures. A full drug release study, degradability and tensile modulus experiments are presented on a simple architecture to validating the suitability of this methodology to identify printable inks for 3D printing devices with bespoke properties.

Citation

Louzao, I., Koch, B., Taresco, V., Ruiz Cantu, L., Irvine, D. J., Roberts, C. J., …Alexander, M. R. (in press). Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery. ACS Applied Materials and Interfaces, 10(8), https://doi.org/10.1021/acsami.7b15677

Journal Article Type Article
Acceptance Date Jan 11, 2018
Online Publication Date Jan 11, 2018
Deposit Date Jan 15, 2018
Publicly Available Date Mar 28, 2024
Journal ACS Applied Materials & Interfaces
Electronic ISSN 1944-8244
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 10
Issue 8
DOI https://doi.org/10.1021/acsami.7b15677
Keywords 3D printing, Drug Delivery, Polymer materials, Biomedical devices, Sustained drug release
Public URL https://nottingham-repository.worktribe.com/output/904019
Publisher URL https://pubs.acs.org/doi/10.1021/acsami.7b15677