All Outputs (1157)

Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes (2013)
Journal Article

Aims Long-QT syndromes (LQTS) are mostly autosomal-dominant congenital disorders associated with a 1:1000 mutation frequency, cardiac arrest, and sudden death. We sought to use cardiomyocytes derived from human-induced pluripotency stem cells (hiPSCs... Read More about Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes.

Transition to adult mental health services for young people with Attention Deficit/Hyperactivity Disorder (ADHD): A qualitative analysis of their experiences (2013)
Journal Article

Background There is little research on the process of transition between child and adolescent mental health services (CAMHS) and adult mental health services (AMHS). More recently, there is growing recognition that Attention Deficit/Hyperactivity Di... Read More about Transition to adult mental health services for young people with Attention Deficit/Hyperactivity Disorder (ADHD): A qualitative analysis of their experiences.

Corticotropin-releasing factor receptor 1 activation during exposure to novelty stress protects against alzheimer's disease-like cognitive decline in A?PP/PS1 Mice (2013)
Journal Article

A lifestyle rich in physical and mental activities protects against Alzheimer's disease (AD) but the underlying mechanisms are unclear. We have proposed that this is mediated by a stress response and have shown that repeated exposure to novelty stres... Read More about Corticotropin-releasing factor receptor 1 activation during exposure to novelty stress protects against alzheimer's disease-like cognitive decline in A?PP/PS1 Mice.

What promotes greater use of the corporate bond market? A study of the issuance behaviour of firms in Asia (2013)
Journal Article

This paper investigates bond market development in Asia by exploring the determinants of firms’ decisions to issue public debt in a range of Asian economies. Using a novel database covering the period 1995 to 2007, we use comparable micro level panel... Read More about What promotes greater use of the corporate bond market? A study of the issuance behaviour of firms in Asia.

Efficacy and safety of maintenance and reliever combination budesonide–formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial (2013)
Journal Article

Background The Single combination budesonide–formoterol inhaler Maintenance And Reliever Therapy (SMART) regimen reduces severe asthma exacerbations in patients, but whether the high doses of corticosteroid and β agonist increase the risk of adverse... Read More about Efficacy and safety of maintenance and reliever combination budesonide–formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial.

Structural reorganisation of cellulose fibrils in hydrothermally deconstructed lignocellulosic biomass and relationships with enzyme digestibility (2013)
Journal Article

Background: The investigation of structural organisation in lignocellulose materials is important to understand changes in cellulase accessibility and reactivity resulting from hydrothermal deconstruction, to allow development of strategies to maxi... Read More about Structural reorganisation of cellulose fibrils in hydrothermally deconstructed lignocellulosic biomass and relationships with enzyme digestibility.

Gold Nanoparticles with Self-Assembled Cysteine Monolayer Coupled to Nitrate Reductase in Polypyrrole Matrix Enhanced Nitrate Biosensor (2013)
Journal Article

Modified prone position to dissect the popliteal fossa (2013)
Journal Article

Introduction: Traditionally, the prone position is used for dissecting the popliteal fossa, which requires endotracheal intubation. Access to the airway in this position is limited, hence the complications. It is not surprising that the prone positio... Read More about Modified prone position to dissect the popliteal fossa.

Dietary fatty acids and cardiovascular disease (2013)
Journal Article

In 1991, the Committee on Medical Aspects of Food Policy produced a report on the dietary reference values for food energy and nutrients for groups of people in the United Kingdom. The resulting recommendations, which included specific limits for int... Read More about Dietary fatty acids and cardiovascular disease.

Identifying road defect information from smartphones (2013)
Journal Article

Defect repair, for example potholes, is one of the most common and expensive tasks of road maintenance. One of the difficulties of this form of asset management is in identifying these defects early. Although a defect may take many years to initiate,... Read More about Identifying road defect information from smartphones.

Physics-of-failure lifetime prediction models for wire bond interconnects in power electronic modules (2013)
Journal Article

This paper presents a review of the commonly adopted physics-of-failure-based life prediction models for wire bond interconnects in power electronic modules. In the discussed models, lifetime is generally accounted for by loading temperature extreme... Read More about Physics-of-failure lifetime prediction models for wire bond interconnects in power electronic modules.

Peer education for advance care planning: volunteers’ perspectives on training and community engagement activities (2013)
Journal Article

Background  Peer education by volunteers may aid attitudinal change, but there is little understanding of factors assisting the preparation of peer educators. This study contributes to conceptual understandings of how volunteers may be prepared to wo... Read More about Peer education for advance care planning: volunteers’ perspectives on training and community engagement activities.

Do patients registered with CAM-trained GPs really use fewer health care resources and live longer? A response to Kooreman and Baars. Eur J Health Econ (2012). 13:469–776 (2013)
Journal Article

Current status of drug screening and disease modelling in human pluripotent stem cells (2013)
Journal Article

The emphasis in human pluripotent stem cell (hPSC) technologies has shifted from cell therapy to in vitro disease modelling and drug screening. This review examines why this shift has occurred, and how current technological limitations might be overc... Read More about Current status of drug screening and disease modelling in human pluripotent stem cells.

Glacial discharge along the west Antarctic Peninsula during the Holocene (2013)
Journal Article

The causes for rising temperatures along the Antarctic Peninsula during the late Holocene have been debated, particularly in light of instrumental records of warming over the past decades. Suggested mechanisms range from upwelling of warm deep waters... Read More about Glacial discharge along the west Antarctic Peninsula during the Holocene.

Behaviour of the extended Volterra lattice (2013)
Journal Article

We investigate the behaviour of solutions of the recently proposed extended Volterra lattice. A variety of methods are used to determine the effects of the new terms on small amplitude equations, and, following approximation of the partial differenti... Read More about Behaviour of the extended Volterra lattice.

Nucleases in Bdellovibrio bacteriovorus contribute towards efficient self-biofilm formation and eradication of preformed prey biofilms (2013)
Journal Article

Bdellovibrio bacteriovorus are predatory bacteria that burrow into prey bacteria and degrade their cell contents, including DNA and RNA, to grow. Their genome encodes diverse nucleases, some with potential export sequences. Transcriptomic analysis de... Read More about Nucleases in Bdellovibrio bacteriovorus contribute towards efficient self-biofilm formation and eradication of preformed prey biofilms.

Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD (2013)
Journal Article

Background Although renal impairment has been described in COPD, there is opportunity to evaluate further to determine nature and consider optimal management. Increased aortic stiffness, as seen in COPD, leads to reduced buffering of pulsatile flow.... Read More about Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD.

Non-compliance and instrumental variables in behavioural medicine: a commentary on van Dongen et al. (2013)
Journal Article

Laboratory adapted Escherichia coli K-12 becomes a pathogen of Caenorhabditis elegans upon restoration of O antigen biosynthesis (2013)
Journal Article

Escherichia coli has been the leading model organism for many decades. It is a fundamental player in modern biology, facilitating the molecular biology revolution of the last century. The acceptance of E.?coli as model organism is predicated primaril... Read More about Laboratory adapted Escherichia coli K-12 becomes a pathogen of Caenorhabditis elegans upon restoration of O antigen biosynthesis.