All Outputs (594)

Beyond resistance and nationalism: local history and the case of Afaq Khoja (2012)
Journal Article

Kashgar's seventeenth-century ruler-saint, Afaq Khoja, is remarkable for the amount of historical writing he has inspired, both outside and within Chinese Turkestan. His reputation among Uyghur historians is one of the few aspects of local Uyghur his... Read More about Beyond resistance and nationalism: local history and the case of Afaq Khoja.

Lost in translation? Psychometric properties and construct validity of the English Essen Climate Evaluation Schema (EssenCES) social climate questionnaire (2012)
Journal Article

A randomised trial of primary tamoxifen versus mastectomy plus adjuvant tamoxifen in fit elderly women with invasive breast carcinoma of high oestrogen receptor content: long-term results at 20 years of follow-up (2012)
Journal Article

Background Long-term analysis of a randomised trial in Nottingham comparing tamoxifen versus surgery as initial treatment demonstrated that in oestrogen receptor (ER)-unselected cases, surgery achieved better local control, with no difference in ove... Read More about A randomised trial of primary tamoxifen versus mastectomy plus adjuvant tamoxifen in fit elderly women with invasive breast carcinoma of high oestrogen receptor content: long-term results at 20 years of follow-up.

A new model and a hyper-heuristic approach for two-dimensional shelf space allocation (2012)
Journal Article

In this paper, we propose a two-dimensional shelf space allocation model. The second dimension stems from the height of the shelf. This results in an integer nonlinear programming model with a complex form of objective function. We propose a multiple... Read More about A new model and a hyper-heuristic approach for two-dimensional shelf space allocation.

Future bronchodilator therapy: a bitter pill to swallow? (2012)
Journal Article

The challenge of Schmallenberg virus emergence in Europe (2012)
Journal Article

The large-scale outbreak of disease across Northern Europe caused by a new orthobunyavirus known as Schmallenberg virus has caused considerable disruption to lambing and calving. Although advances in technology and collaboration between veterinary... Read More about The challenge of Schmallenberg virus emergence in Europe.

Cost effectiveness of epidural steroid injections to manage chronic lower back pain (2012)
Journal Article

Background The efficacy of epidural steroid injections in the management of chronic low back pain is disputed, yet the technique remains popular amongst physicians and patients alike. This study assesses the cost effectiveness of injections administ... Read More about Cost effectiveness of epidural steroid injections to manage chronic lower back pain.

Reliability of quantitative echocardiography in adult sheep and goats (2012)
Journal Article

Background Echocardiography is a non-invasive method for assessment of the ovine and caprine heart. Complete reference ranges for cardiac dimensions and time indices for both species are not currently available and reliability of these measurements... Read More about Reliability of quantitative echocardiography in adult sheep and goats.

Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in acute Myeloid Leukaemia (2012)
Journal Article

Background The CD34+CD38- subset of AML cells is enriched for resistance to current chemotherapeutic agents and considered to contribute to disease progression and relapse in Acute Myeloid Leukaemia (AML) patients following initial treatment. Met... Read More about Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in acute Myeloid Leukaemia.

Perceptual learning reconfigures the effects of visual adaptation (2012)
Journal Article

Our sensory experiences over a range of different timescales shape our perception of the environment. Two particularly striking short-term forms of plasticity with manifestly different time courses and perceptual consequences are those caused by visu... Read More about Perceptual learning reconfigures the effects of visual adaptation.

Cognitive control over motor output in Tourette syndrome (2012)
Journal Article

Tourette syndrome [TS] is a neurodevelopmental disorder characterised by chronic vocal and motor tics. TS has been associated with dysfunctional cognitive (inhibitory) control of behaviour, however the evidence for this, beyond the occurrence of tics... Read More about Cognitive control over motor output in Tourette syndrome.

WNT/?-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma (2012)
Journal Article

Background: Medulloblastoma is the most common malignant childhood brain tumour. Aberrant activation of the WNT/β-catenin pathway occurs in approximately 25% of medulloblastomas. However, its role in medulloblastoma pathogenesis is not understood.... Read More about WNT/?-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma.

Mapping the laminin receptor binding domains of Neisseria meningitidis PorA and Haemophilus influenzae OmpP2 (2012)
Journal Article

Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae are major bacterial agents of meningitis. They each bind the 37/67-kDa laminin receptor (LamR) via the surface protein adhesins: meningococcal PilQ and PorA, H. influenzae Om... Read More about Mapping the laminin receptor binding domains of Neisseria meningitidis PorA and Haemophilus influenzae OmpP2.

Why are family carers of people with dementia dissatisfied with general hospital care?: a qualitative study (2012)
Journal Article

Background Families and other carers report widespread dissatisfaction with general hospital care for confused older people. Methods We undertook a qualitative interviews study of 35 family carers of 34 confused older patients to ascertain their... Read More about Why are family carers of people with dementia dissatisfied with general hospital care?: a qualitative study.

Why is the Liverpool care pathway used for some dying cancer patients and not others? Healthcare professionals’ perspectives (2012)
Journal Article

Background: Despite evidence suggesting that the Liverpool Care Pathway for the Dying Patient is a structured and proficient means of supporting care delivery in the last hours or days of life, discrepancies in uptake are widespread. This explorator... Read More about Why is the Liverpool care pathway used for some dying cancer patients and not others? Healthcare professionals’ perspectives.

Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female (2012)
Journal Article

In Drosophila, the accessory gland proteins (Acps) secreted from the male accessory glands (MAGs) and transferred along with sperm into the female reproductive tract have been implicated in triggering postmating behavioral changes, including refracto... Read More about Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female.

A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion (2012)
Journal Article

Protein phosphorylation and dephosphorylation (catalysed by kinases and phosphatases, respectively) are post-translational modifications that play key roles in many eukaryotic signalling pathways, and are often deregulated in a number of pathological... Read More about A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion.

A cooperative instinct (2012)
Journal Article

Acting on a gut feeling may sometimes lead to poor decisions, but it will usually support the common good, according to a study showing that human intuition favours cooperative, rather than selfish, behaviour.

Coping with and factors impacting upon the experience of lung cancer in patients and primary carers (2012)
Journal Article

There is a paucity of research exploring patients' and their informal carers' experience of coping with and factors impacting on the lung cancer experience. This study aims to explore how patients and their informal carers cope with a diagnosis of lu... Read More about Coping with and factors impacting upon the experience of lung cancer in patients and primary carers.

A Bayesian elicitation of veterinary beliefs regarding systemic dry cow therapy: variation and importance for clinical trial design (2012)
Journal Article

The two key aims of this research were: (i) to conduct a probabilistic elicitation to quantify the variation in veterinarians’ beliefs regarding the efficacy of systemic antibiotics when used as an adjunct to intra-mammary dry cow therapy and (ii) to... Read More about A Bayesian elicitation of veterinary beliefs regarding systemic dry cow therapy: variation and importance for clinical trial design.