S. J. Johnston
A randomised trial of primary tamoxifen versus mastectomy plus adjuvant tamoxifen in fit elderly women with invasive breast carcinoma of high oestrogen receptor content: long-term results at 20 years of follow-up
Johnston, S. J.; Kenny, F. S.; Syed, B. M.; Robertson, J. F. R.; Pinder, S. E.; Winterbottom, L.; Ellis, I. O.; Blamey, R. W.; Cheung, K. L.
Authors
F. S. Kenny
B. M. Syed
Professor JOHN ROBERTSON john.robertson@nottingham.ac.uk
PROFESSOR OF SURGERY
S. E. Pinder
L. Winterbottom
I. O. Ellis
R. W. Blamey
Professor KWOK_LEUNG CHEUNG KWOK_LEUNG.CHEUNG@NOTTINGHAM.AC.UK
DEPUTY HEAD OF EDUCATION & DIRECTOR OF THE BMBS MEDICINE PROGRAMMES
Abstract
Background
Long-term analysis of a randomised trial in Nottingham comparing tamoxifen versus surgery as initial treatment demonstrated that in oestrogen receptor (ER)-unselected cases, surgery achieved better local control, with no difference in overall survival. It was suggested that for patients with ER-rich tumours, local control and survival may be comparable. We now present long-term follow-up of a randomised trial designed to address this clinical scenario.
Patients and methods
One hundred and fifty three fit elderly (≥70 years) women with clinically node-negative primary invasive breast carcinoma
Citation
Johnston, S. J., Kenny, F. S., Syed, B. M., Robertson, J. F. R., Pinder, S. E., Winterbottom, L., Ellis, I. O., Blamey, R. W., & Cheung, K. L. (2012). A randomised trial of primary tamoxifen versus mastectomy plus adjuvant tamoxifen in fit elderly women with invasive breast carcinoma of high oestrogen receptor content: long-term results at 20 years of follow-up. Annals of Oncology, 23(9), 2296-2300. https://doi.org/10.1093/annonc/mdr630
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 20, 2011 |
Online Publication Date | Jan 6, 2020 |
Publication Date | 2012-09 |
Deposit Date | Nov 28, 2018 |
Journal | Annals of Oncology |
Print ISSN | 0923-7534 |
Electronic ISSN | 1569-8041 |
Publisher | Oxford University Press |
Peer Reviewed | Peer Reviewed |
Volume | 23 |
Issue | 9 |
Pages | 2296-2300 |
DOI | https://doi.org/10.1093/annonc/mdr630 |
Public URL | https://nottingham-repository.worktribe.com/output/1138781 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S0923753419351993?via%3Dihub |
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