Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition

Smith, Stuart J.; Wilson, Martin; Ward, Jennifer H.; Rahman, Cheryl V.; Peet, Andrew C.; Macarthur, Donald C.; Rose, Felicity R.A.J.; Grundy, Richard G.; Rahman, Ruman

doi:10.1371/journal.pone.0052335

Women, Mothers, and Priests in the Church of England. What a Vocation! (2012)
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This paper will consider how women priests in the Church of England have been incorporated into the occupational life of the Church, highlighting the ways in which women are negotiating a discriminatory terrain. Although general opposition to women’s... Read More about Women, Mothers, and Priests in the Church of England. What a Vocation!.

Using the "documentary method" to analyse qualitative data in logistics research (2012)
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Purpose This paper aims to examine the use of a qualitative data analysis technique, the documentary method, in the development of knowledge in logistics. The value of the method is illustrated through an example of its application in a study of i... Read More about Using the "documentary method" to analyse qualitative data in logistics research.

Tissue-specific expression of p73 C-terminal isoforms in mice (2012)
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p73 is a p53 family transcription factor. Due to the presence in the 5? flanking region of two promoters, there are two N-terminal variants, TAp73, which retains a fully active transactivation domain (TA), and ?Np73, in which the N terminus is trunca... Read More about Tissue-specific expression of p73 C-terminal isoforms in mice.

Indirect object recognition: Evidence for associative processes in recognition memory (2012)
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Fulham 878–79: a new consideration of Viking manoeuvres (2012)
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This paper uses evidence from a variety of disciplines in order to re-evaluate an apparently enigmatic event reported in several early sources – the landing of a Viking force at Fulham in 878. It examines the vocabulary of written accounts of their a... Read More about Fulham 878–79: a new consideration of Viking manoeuvres.

Social care in older people's services-facilitating the flexible use of resources (2012)
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Personal budgets in social care are a mechanism for the allocation of resources for care that permits users' greater choice and flexibility. This study was designed to explore developments in care coordination arrangements by examining the flexible u... Read More about Social care in older people's services-facilitating the flexible use of resources.

Optimization of switching losses and capacitor voltage ripple using model predictive control of a cascaded H-bridge multi-level StatCom (2012)
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This paper further develops a Model Predictive Control (MPC) scheme which is able to exploit the large number of redundant switching states available in a multi-level H-bridge StatCom (H-StatCom). The new sections of the scheme provide optimised meth... Read More about Optimization of switching losses and capacitor voltage ripple using model predictive control of a cascaded H-bridge multi-level StatCom.

A comparison of the content of memory rehabilitation groups for patients with neurological disabilities (2012)
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The aim of the study was to compare the fidelity of manualised group memory rehabilitation programmes for participants with neurological disabilities. A sample of 11 neurological patients with memory problems, enrolled in a ran¬domised controlled tri... Read More about A comparison of the content of memory rehabilitation groups for patients with neurological disabilities.

Experimental measurement and theoretical assessment of fast lanthanide electronic relaxation in solution with four series of isostructural complexes (2012)
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The rates of longitudinal relaxation for ligand nuclei in four isostructural series of lanthanide(III) complexes have been measured by solution state NMR at 295 K at five magnetic fields in the range 4.7-16.5 T. The electronic relaxation time Tle is... Read More about Experimental measurement and theoretical assessment of fast lanthanide electronic relaxation in solution with four series of isostructural complexes.

Development of a poststroke checklist to standardize follow-up care for stroke survivors (2012)
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Background: Long-termcare for stroke survivors is fragmented and lacks an evidence-based, easy-to-use tool to identify persistent long-term problems among stroke survivors and streamline referral for treatment. We sought to develop a poststroke check... Read More about Development of a poststroke checklist to standardize follow-up care for stroke survivors.

Analysis of ripening-related gene expression in papaya using an Arabidopsis-based microarray (2012)
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Background Papaya (Carica papaya L.) is a commercially important crop that produces climacteric fruits with a soft and sweet pulp that contain a wide range of health promoting phytochemicals. Despite its importance, little is known about transcrip... Read More about Analysis of ripening-related gene expression in papaya using an Arabidopsis-based microarray.

Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem (2012)
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Background and Purpose Prokineticin 2 (PK2) has recently been shown to acutely reduce food intake in rodents. We aimed to determine the CNS sites and receptors that mediate the anorectic effects of peripherally administered PK2 and its chronic effect... Read More about Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem.

The socio-technical organisation of community pharmacies as a factor in the Electronic Prescription Service Release Two implementation: a qualitative study (2012)
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Use of metered-dose inhaler electronic monitoring in a real-world asthma randomized controlled trial (2012)
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Background Electronic monitoring of inhaled asthma medications is one method to measure medication adherence and patterns of use. Information on the performance of monitors in a randomized controlled trial allows researchers and clinicians to unde... Read More about Use of metered-dose inhaler electronic monitoring in a real-world asthma randomized controlled trial.

A neural network approach to predicting price negotiation outcomes in business-to-business contexts (2012)
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Price premiums are a key profit driver for long-term business relationships. For sellers in business-to-business (B2B) relationships, it is important to have appropriate strategies to negotiate price increases without trading off the relationships wi... Read More about A neural network approach to predicting price negotiation outcomes in business-to-business contexts.

Soft-bound synaptic plasticity increases storage capacity (2012)
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Accurate models of synaptic plasticity are essential to understand the adaptive properties of the nervous system and for realistic models of learning and memory. Experiments have shown that synaptic plasticity depends not only on pre- and post-synapt... Read More about Soft-bound synaptic plasticity increases storage capacity.

What do we mean by wet? Geoarchaeology and the reconstruction of water availability (2012)
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Geoarchaeology has a key role to play in the human-climate-environment debate, including research into the controls and variability of water availability. However its interdisciplinarity can cause complications as well as advantages and leads to conf... Read More about What do we mean by wet? Geoarchaeology and the reconstruction of water availability.

Can GPs working in secure environments in England re-license using the Royal College of General Practitioners revalidation proposals? (2012)
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Background Revalidation for UK doctors is expected to be introduced from late 2012. For general practitioners (GPs), this entails collecting supporting information to be submitted and assessed in a revalidation portfolio every five years. The aim of... Read More about Can GPs working in secure environments in England re-license using the Royal College of General Practitioners revalidation proposals?.

Medieval business networks: St Mary's guild and the borough court in later medieval Nottingham (2012)
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Historians have suggested that medieval urban guilds played a role in political and commercial networking. Guilds' commercial protectionism was designed to benefit their membership and close ties have been discovered between merchant guilds and urban... Read More about Medieval business networks: St Mary's guild and the borough court in later medieval Nottingham.

Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition (2012)
Journal Article

INTRODUCTION Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated... Read More about Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.

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