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All Outputs (294)

PRH/Hex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling (2010)
Journal Article
Noy, P., Williams, H., Sawasdichai, A., Gaston, K., & Jayaraman, P.-S. (2010). PRH/Hex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling. Molecular and Cellular Biology, 30(9), 2120-2134. https://doi.org/10.1128/MCB.01511-09

The proline-rich homeodomain protein (PRH) plays multiple roles in the control of gene expression during embryonic development and in the adult. Vascular endothelial growth factor (VEGF) is a mitogen that stimulates cell proliferation and survival vi... Read More about PRH/Hex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling.

RepD-mediated recruitment of PcrA helicase at the Staphylococcus aureus pC221 plasmid replication origin, oriD (2010)
Journal Article
Machόn, C., Thomson, N., Lynch, G., Scott, D. J., Thomas, C., & Soultanas, P. (2010). RepD-mediated recruitment of PcrA helicase at the Staphylococcus aureus pC221 plasmid replication origin, oriD. Nucleic Acids Research, 38(6), https://doi.org/10.1093/nar/gkp1153

Plasmid encoded replication initiation (Rep) proteins recruit host helicases to plasmid replication origins. Previously, we showed that RepD recruits directionally the PcrA helicase to the pC221 oriD, remains associated with it, and increases its pro... Read More about RepD-mediated recruitment of PcrA helicase at the Staphylococcus aureus pC221 plasmid replication origin, oriD.

Short-days induce weight loss in siberian hamsters despite overexpression of the agouti-related peptide gene (2010)
Journal Article
Jethwa, P. H., Warner, A., Fowler, M. J., Murphy, M., de Backer, M. W., Adan, R. A., Barrett, P., Brameld, J. M., & Ebling, F. J. (2010). Short-days induce weight loss in siberian hamsters despite overexpression of the agouti-related peptide gene. Journal of Neuroendocrinology, 22(6), 564-575. https://doi.org/10.1111/j.1365-2826.2010.02001.x

Many vertebrates express profound annual cycles of body fattening, although it is not clear whether these represent differential activity of the central pathways known to mediate homeostatic control of food intake and energy expenditure, or whether t... Read More about Short-days induce weight loss in siberian hamsters despite overexpression of the agouti-related peptide gene.

Living with HIV/AIDS and use of online support groups (2010)
Journal Article
Mo, P. K., & Coulson, N. S. (2010). Living with HIV/AIDS and use of online support groups. Journal of Health Psychology, 15(3), 339-350. https://doi.org/10.1177/1359105309348808

The present study explores the association between online support group use and health status, coping and social support among 640 individuals with HIV/AIDS. Results suggested that frequent users tended to be female, younger, single, and in a more ad... Read More about Living with HIV/AIDS and use of online support groups.

Stochastic and deterministic multiscale models for systems biology: An auxin-transport case study (2010)
Journal Article
Twycross, J., Band, L. R., Bennett, M. J., King, J. R., & Krasnogor, N. (2010). Stochastic and deterministic multiscale models for systems biology: An auxin-transport case study. BMC Systems Biology, 4, https://doi.org/10.1186/1752-0509-4-34

Background: Stochastic and asymptotic methods are powerful tools in developing multiscale systems biology models; however, little has been done in this context to compare the efficacy of these methods. The majority of current systems biology modellin... Read More about Stochastic and deterministic multiscale models for systems biology: An auxin-transport case study.

Hybrid ortho/allosteric ligands for the adenosine A(1) receptor (2010)
Journal Article
Narlawar, R., Lane, J. R., Doddareddy, M., Lin, J., Brussee, J., & Ijzerman, A. P. (2010). Hybrid ortho/allosteric ligands for the adenosine A(1) receptor. Journal of Medicinal Chemistry, 53(8), 3028-3037. https://doi.org/10.1021/jm901252a

Many G protein-coupled receptors (GPCRs), including the adenosine A(1) receptor (A(1)AR), have been shown to be allosterically modulated by small molecule ligands. So far, in the absence of structural information, the exact location of the allosteric... Read More about Hybrid ortho/allosteric ligands for the adenosine A(1) receptor.

Community pharmacists' views on adverse drug reactions reporting in Malaysia: A pilot study (2010)
Journal Article
Ting, K.-N., Stratton-Powell, D. M., & Anderson, C. (2010). Community pharmacists' views on adverse drug reactions reporting in Malaysia: A pilot study. Pharmacy World and Science, 32, 339–342. https://doi.org/10.1007/s11096-010-9382-0

Objectives To investigate community pharmacists’ knowledge, attitudes and views on adverse drug reaction (ADR) reporting. Setting Seven community pharmacies in Malaysia. Method Structured interviews with community pharmacists. Informed consent was ob... Read More about Community pharmacists' views on adverse drug reactions reporting in Malaysia: A pilot study.

Targeting, care management and preventative services for older people: The cost-effectiveness of a pilot self-assessment approach in one local authority (2010)
Journal Article
Clarkson, P., Hughes, J., Challis, D., Thorley, L., & Kilshaw, C. (2010). Targeting, care management and preventative services for older people: The cost-effectiveness of a pilot self-assessment approach in one local authority. British Journal of Social Work, 40(7), 2255-2273. https://doi.org/10.1093/bjsw/bcq042

As social services councils face a more constrained economic environment and as eligibility criteria tighten, the issue of targeting becomes increasingly relevant. This paper presents findings from a pilot project in one local authority that aimed to... Read More about Targeting, care management and preventative services for older people: The cost-effectiveness of a pilot self-assessment approach in one local authority.

TopoGSA: network topological gene set analysis (2010)
Journal Article
Glaab, E., Baudot, A., Krasnogor, N., & Valencia, A. (2010). TopoGSA: network topological gene set analysis. Bioinformatics, 26(9), https://doi.org/10.1093/bioinformatics/btq131

TopoGSA (Topology-based Gene Set Analysis) is a web-application dedicated to the computation and visualization of network topological properties for gene and protein sets in molecular interaction networks. Different topological characteristics, such... Read More about TopoGSA: network topological gene set analysis.

Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration (2010)
Journal Article
Rogers, N., Paine, S., Bedford, L., & Layfield, R. (2010). Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration. Neuropathology and Applied Neurobiology, 36(2), 113-124. https://doi.org/10.1111/j.1365-2990.2010.01063.x

The significance of the accumulation of ubiquitin-positive intraneuronal inclusions in the brains of those affected with different neurodegenerative diseases is currently unclear. While one interpretation is that the disease mechanism(s) involves dys... Read More about Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration.

Garlic as an inhibitor of pseudomonas aeruginosa quorum sensing in cystic fibrosis - A pilot randomized controlled trial (2010)
Journal Article
Smyth, A. R., Cifelli, P. M., Ortori, C. A., Righetti, K., Lewis, S., Erskine, P., Holland, E. D., Givskov, M., Williams, P., Cámara, M., Barrett, D. A., & Knox, A. (2010). Garlic as an inhibitor of pseudomonas aeruginosa quorum sensing in cystic fibrosis - A pilot randomized controlled trial. Pediatric Pulmonology, 45(4), 356-362. https://doi.org/10.1002/ppul.21193

Pseudomonas aeruginosa forms biofilms in the cystic fibrosis lung. Quorum sensing (QS) controls biofilm maturation, immune evasion, antibiotic tolerance and virulence factor production. Garlic shows QS inhibitory activity in vitro and in animal model... Read More about Garlic as an inhibitor of pseudomonas aeruginosa quorum sensing in cystic fibrosis - A pilot randomized controlled trial.

Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy (2010)
Journal Article
Mistry, H., Kurlak, L., Williams, P., Ramsay, M., Symonds, M., & Broughton Pipkin, F. (2010). Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy. Placenta, 31(5), https://doi.org/10.1016/j.placenta.2010.02.011

Preeclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality; it may also predispose the mother and fetus to increased risks of adult cardiovascular disease. The selenopr... Read More about Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy.

'They all supported me but I felt like I suddenly didn't belong anymore': An exploration of perceived disadvantages to online support seeking (2010)
Journal Article
Malik, S., & Coulson, N. S. (2010). 'They all supported me but I felt like I suddenly didn't belong anymore': An exploration of perceived disadvantages to online support seeking. Journal of Psychosomatic Obstetrics and Gynecology, 31(3), 140-149. https://doi.org/10.3109/0167482X.2010.504870

In recent years, there has been a significant rise in the number of online support communities dedicated to issues surrounding infertility. The aim of this study was to focus on investigating the perceived disadvantages of online infertility support... Read More about 'They all supported me but I felt like I suddenly didn't belong anymore': An exploration of perceived disadvantages to online support seeking.

Case management for long-term conditions: Developing targeting processes (2010)
Journal Article
Abell, J., Hughes, J., Reilly, S., Berzins, K., & Challis, D. (2010). Case management for long-term conditions: Developing targeting processes. Care Management Journals, 11(1), 11-18. https://doi.org/10.1891/1521-0987.11.1.11

Intensive case management (ICM) is traditionally targeted atpatients with complex needs and exists within a wider service context. Targeting is integral to the efficiency of the service. A process and outcome evaluation of case management wasconducte... Read More about Case management for long-term conditions: Developing targeting processes.

Differential Yeast Gene Transcription During Brewery Propagation (2010)
Journal Article
Gibson, B. R., Graham, N. S., Boulton, C. A., Box, W. G., Lawrence, S. J., Linforth, R. S. T., May, S. T., & Smart, K. A. (2010). Differential Yeast Gene Transcription During Brewery Propagation. Journal of The American Society of Brewing Chemists, 68(1), 21-29. https://doi.org/10.1094/ASBCJ-2009-1123-01

The aim of this study was to determine the transcriptomic response of Saccharomyces pastorianus to environmental change during brewery propagation. Utilization of amino acids and fermentable carbohydrates during fullscale brewery propagation was comp... Read More about Differential Yeast Gene Transcription During Brewery Propagation.

A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients (2010)
Journal Article
Soria, D., Garibaldi, J. M., Ambrogi, F., Green, A. R., Powe, D., Rakha, E., Douglas Macmillan, R., Blamey, R. W., Ball, G., Lisboa, P. J., Etchells, T. A., Boracchi, P., Biganzoli, E. M., & Ellis, I. O. (2010). A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients. Computers in Biology and Medicine, 40(3), https://doi.org/10.1016/j.compbiomed.2010.01.003

Single clustering methods have often been used to elucidate clusters in high dimensional medical data, even though reliance on a single algorithm is known to be problematic. In this paper, we present a methodology to determine a set of ‘core classes’... Read More about A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients.

Carbon gold rush and carbon cowboys: a new chapter in green mythology? (2010)
Journal Article
Nerlich, B., & Koteyko, N. (2010). Carbon gold rush and carbon cowboys: a new chapter in green mythology?. Environmental Communication, 4(1), https://doi.org/10.1080/17524030903522389

Individual and collective efforts to mitigate climate change in the form of carbon offsetting and emissions trading schemes have recently become the focus of much media attention. In this paper we explore a subset of the UK national press coverage ce... Read More about Carbon gold rush and carbon cowboys: a new chapter in green mythology?.

Adaptivity and a posteriori error control for bifurcation problems II: Incompressible fluid flow in open systems with Z_2 symmetry (2010)
Journal Article
Cliffe, A., Hall, E., Houston, P., Phipps, E. T., & Salinger, A. G. Adaptivity and a posteriori error control for bifurcation problems II: Incompressible fluid flow in open systems with Z_2 symmetry. Manuscript submitted for publication

In this article we consider the a posteriori error estimation and adaptive mesh refinement of discontinuous Galerkin finite element approximations of the bifurcation problem associated with the steady incompressible Navier-Stokes equations. Particula... Read More about Adaptivity and a posteriori error control for bifurcation problems II: Incompressible fluid flow in open systems with Z_2 symmetry.