Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration

Rogers, N.; Paine, S.; Bedford, L.; Layfield, R.

Abstract

The significance of the accumulation of ubiquitin-positive intraneuronal inclusions in the brains of those affected with different neurodegenerative diseases is currently unclear. While one interpretation is that the disease mechanism(s) involves dysfunction of an ubiquitin-mediated process, such as the ubiquitin-proteasome system, the inclusions are also found in surviving neurones, suggesting a possible neuroprotective role. Here we review recent evidence in support of these seemingly opposing notions gleaned from cell and animal models as well as investigations of patient samples, with particular emphasis on studies relevant to Parkinson's disease. © 2010 Blackwell Publishing Ltd.

Citation

Rogers, N., Paine, S., Bedford, L., & Layfield, R. (2010). Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration. Neuropathology and Applied Neurobiology, 36(2), 113-124. https://doi.org/10.1111/j.1365-2990.2010.01063.x

• Journal Article Type: Article
• Acceptance Date: Feb 19, 2010
• Online Publication Date: Mar 23, 2010
• Publication Date: 2010-04
• Deposit Date: Dec 5, 2018
• Journal: Neuropathology and Applied Neurobiology
• Print ISSN: 0305-1846
• Electronic ISSN: 1365-2990
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 36
• Issue: 2
• Pages: 113-124
• DOI: https://doi.org/10.1111/j.1365-2990.2010.01063.x
• Public URL: https://nottingham-repository.worktribe.com/output/1175447
• Publisher URL: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2990.2010.01063.x