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Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration

Rogers, N.; Paine, S.; Bedford, L.; Layfield, R.

Authors

N. Rogers

L. Bedford



Abstract

The significance of the accumulation of ubiquitin-positive intraneuronal inclusions in the brains of those affected with different neurodegenerative diseases is currently unclear. While one interpretation is that the disease mechanism(s) involves dysfunction of an ubiquitin-mediated process, such as the ubiquitin-proteasome system, the inclusions are also found in surviving neurones, suggesting a possible neuroprotective role. Here we review recent evidence in support of these seemingly opposing notions gleaned from cell and animal models as well as investigations of patient samples, with particular emphasis on studies relevant to Parkinson's disease. © 2010 Blackwell Publishing Ltd.

Journal Article Type Article
Publication Date 2010-04
Journal Neuropathology and Applied Neurobiology
Print ISSN 0305-1846
Electronic ISSN 1365-2990
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 36
Issue 2
Pages 113-124
APA6 Citation Rogers, N., Paine, S., Bedford, L., & Layfield, R. (2010). Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration. Neuropathology and Applied Neurobiology, 36(2), 113-124. https://doi.org/10.1111/j.1365-2990.2010.01063.x
DOI https://doi.org/10.1111/j.1365-2990.2010.01063.x
Publisher URL https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2990.2010.01063.x
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