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Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration

Rogers, N.; Paine, S.; Bedford, L.; Layfield, R.

Authors

N. Rogers

STUART PAINE Stuart.Paine@nottingham.ac.uk
Professor of Pharmacometrics

L. Bedford

ROBERT LAYFIELD ROBERT.LAYFIELD@NOTTINGHAM.AC.UK
Professor of Protein Biochemistry



Abstract

The significance of the accumulation of ubiquitin-positive intraneuronal inclusions in the brains of those affected with different neurodegenerative diseases is currently unclear. While one interpretation is that the disease mechanism(s) involves dysfunction of an ubiquitin-mediated process, such as the ubiquitin-proteasome system, the inclusions are also found in surviving neurones, suggesting a possible neuroprotective role. Here we review recent evidence in support of these seemingly opposing notions gleaned from cell and animal models as well as investigations of patient samples, with particular emphasis on studies relevant to Parkinson's disease. © 2010 Blackwell Publishing Ltd.

Citation

Rogers, N., Paine, S., Bedford, L., & Layfield, R. (2010). Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration. Neuropathology and Applied Neurobiology, 36(2), 113-124. https://doi.org/10.1111/j.1365-2990.2010.01063.x

Journal Article Type Article
Acceptance Date Feb 19, 2010
Online Publication Date Mar 23, 2010
Publication Date 2010-04
Deposit Date Dec 5, 2018
Journal Neuropathology and Applied Neurobiology
Print ISSN 0305-1846
Electronic ISSN 1365-2990
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 36
Issue 2
Pages 113-124
DOI https://doi.org/10.1111/j.1365-2990.2010.01063.x
Public URL https://nottingham-repository.worktribe.com/output/1175447
Publisher URL https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2990.2010.01063.x