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Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare diseases translational research collaborative (2020)
Journal Article
Crossley, D., Stockley, J., Bolton, C. E., Hopkinson, N. S., Mahadeva, R., Steiner, M., …Stockley, R. A. (2020). Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare diseases translational research collaborative. BMJ Open, 10(6), Article e036045. https://doi.org/10.1136/bmjopen-2019-036045

Objectives To establish a database network for the study of alpha-1 antitrypsin deficiency (AATD) and compare the results to CT lung density as the most direct measure of emphysema. Design A central electronic database was established to permit th... Read More about Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare diseases translational research collaborative.

Structural and chemical heterogeneity in ancient glass probed using gas overcondensation, X-ray tomography, and solid-state NMR (2020)
Journal Article
Rigby, S. P., Stevens, L., Meersmann, T., Pavlovskaya, G. E., Rees, G. J., Henderson, J., …Fletcher, R. S. (2020). Structural and chemical heterogeneity in ancient glass probed using gas overcondensation, X-ray tomography, and solid-state NMR. Materials Characterization, 167, Article 110467. https://doi.org/10.1016/j.matchar.2020.110467

Rare ancient glasses have complex, multi-scale structures requiring more sophisticated and non-destructive pore characterisation techniques than usual. Homotattic patch models for nitrogen adsorption gave better fits to the isotherm data, more accura... Read More about Structural and chemical heterogeneity in ancient glass probed using gas overcondensation, X-ray tomography, and solid-state NMR.

Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement (2020)
Journal Article
Gupta, A., Jayes, L. R., Holmes, S., Sahota, O., Canavan, M., Elkin, S. L., …Bolton, C. E. (2020). Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement. International Journal of Chronic Obstructive Pulmonary Disease, 15, 1377-1390. https://doi.org/10.2147/copd.s233398

Introduction: Osteoporosis and bone fractures are common in chronic obstructive pulmonary disease (COPD) and contribute significantly to morbidity and mortality. Current national guidance on COPD management recommends addressing bone health in patien... Read More about Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement.

The prognostic significance of BMI1 expression in invasive breast cancer is dependent on its molecular subtypes (2020)
Journal Article
Althobiti, M., Muftah, A. A., Aleskandarany, M. A., Joseph, C., Toss, M. S., Green, A., & Rakha, E. (2020). The prognostic significance of BMI1 expression in invasive breast cancer is dependent on its molecular subtypes. Breast Cancer Research and Treatment, 182, 581–589. https://doi.org/10.1007/s10549-020-05719-x

Purpose: BMI-1, which is a major component of the polycomb group complex 1 is an essential epigenetic repressor of multiple regulatory genes and has been identified as a cancer stem cell (CSC) marker in several cancers. However, its role in breast c... Read More about The prognostic significance of BMI1 expression in invasive breast cancer is dependent on its molecular subtypes.

Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals (2020)
Journal Article
Leisman, D. E., Harhay, M. O., Lederer, D. J., Abramson, M., Adjei, A. A., Bakker, J., …Maslove, D. M. (2020). Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals. Critical Care Medicine, 48(5), 623-633. https://doi.org/10.1097/ccm.0000000000004246

Prediction models aim to use available data to predict a health state or outcome that has not yet been observed. Prediction is primarily relevant to clinical practice, but is also used in research, and administration. While prediction modeling involv... Read More about Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals.

Phenotypic and functional translation of IL33 genetics in asthma (2020)
Journal Article
Ketelaar, M. E., Portelli, M. A., Dijk, F. N., Shrine, N., Faiz, A., Vermeulen, C. J., …Nawijn, M. C. (2021). Phenotypic and functional translation of IL33 genetics in asthma. Journal of Allergy and Clinical Immunology, 147(1), 144-157. https://doi.org/10.1016/j.jaci.2020.04.051

© 2020 Background: Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have been reproducibly associated with asthma. IL33 levels are elevate... Read More about Phenotypic and functional translation of IL33 genetics in asthma.

Operando visualisation of battery chemistry in a sodium-ion battery by 23Na magnetic resonance imaging (2020)
Journal Article
Kendrick, E., Bray, J. M., Doswell, C. L., Pavlovskaya, G. E., Chen, L., Kishore, B., …Britton, M. M. (2020). Operando visualisation of battery chemistry in a sodium-ion battery by 23Na magnetic resonance imaging. Nature Communications, 11(1), Article 2083. https://doi.org/10.1038/s41467-020-15938-x

© 2020, The Author(s). Sodium-ion batteries are a promising battery technology for their cost and sustainability. This has led to increasing interest in the development of new sodium-ion batteries and new analytical methods to non-invasively, directl... Read More about Operando visualisation of battery chemistry in a sodium-ion battery by 23Na magnetic resonance imaging.

Hospital doctors’ attitudes to brief educational messages that aim to modify diagnostic test requests: a qualitative study (2020)
Journal Article
Young, B., Fogarty, A. W., Skelly, R., Shaw, D., Sturrock, N., Norwood, M., …Cranwell, J. (2020). Hospital doctors’ attitudes to brief educational messages that aim to modify diagnostic test requests: a qualitative study. BMC Medical Informatics and Decision Making, 20(1), 80. https://doi.org/10.1186/s12911-020-1087-2

BACKGROUND: Avoidable use of diagnostic tests can both harm patients and increase the cost of healthcare. Nudge-type educational interventions have potential to modify clinician behaviour while respecting clinical autonomy and responsibility, but the... Read More about Hospital doctors’ attitudes to brief educational messages that aim to modify diagnostic test requests: a qualitative study.

CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model (2020)
Journal Article
Ketley, A., Wojciechowska, M., Ghidelli-Disse, S., Bamborough, P., Ghosh, T. K., Morato, M. L., …Brook, J. D. (2020). CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model. Science Translational Medicine, 12(541), Article eaaz2415. https://doi.org/10.1126/scitranslmed.aaz2415

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Myotonic dystrophy type 1 (DM1) is an RNA-based disease with no current treatment.... Read More about CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model.

Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium (2020)
Journal Article
Portelli, M. A., Dijk, F. N., Ketelaar, M. E., Shrine, N., Hankinson, J., Bhaker, S., …Sayers, I. (2020). Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI insight, 5(8), Article 132446. https://doi.org/10.1172/jci.insight.132446

The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying these associations remain to be def... Read More about Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.

Respiratory and Cardiovascular Outcomes in Survivors of Extremely Preterm Birth at 19 Years (2020)
Journal Article
Hurst, J. R., Beckmann, J., Ni, Y., Bolton, C. E., McEniery, C. M., Cockcroft, J. R., & Marlow, N. (2020). Respiratory and Cardiovascular Outcomes in Survivors of Extremely Preterm Birth at 19 Years. American Journal of Respiratory and Critical Care Medicine, 202(3), 422-432. https://doi.org/10.1164/rccm.202001-0016oc

Rationale: Growth and development during adolescence may modify the respiratory and vascular differences seen among extremely preterm (EP) individuals in childhood and early adolescence. Objective: To assess the trajectory of respiratory and cardi... Read More about Respiratory and Cardiovascular Outcomes in Survivors of Extremely Preterm Birth at 19 Years.

The prognostic significance of immune microenvironment in breast ductal carcinoma in situ (2020)
Journal Article
Toss, M. S., Abidi, A., Lesche, D., Joseph, C., Mahale, S., Saunders, H., …Rakha, E. A. (2020). The prognostic significance of immune microenvironment in breast ductal carcinoma in situ. British Journal of Cancer, 122, 1496–1506. https://doi.org/10.1038/s41416-020-0797-7

Background The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lymphocytes and immune checkpo... Read More about The prognostic significance of immune microenvironment in breast ductal carcinoma in situ.

Persistent ventilation inhomogeneity after an acute exacerbation in preschool children with recurrent wheezing (2020)
Journal Article
Kowalik, K., Dai, R., Safavi, S., Reyna, M. E., Lou, W., Lepine, C., …Subbarao, P. (2020). Persistent ventilation inhomogeneity after an acute exacerbation in preschool children with recurrent wheezing. Pediatric Allergy and Immunology, https://doi.org/10.1111/pai.13245

© 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. Background: Preschool children with recurrent wheezing suffer high morbidity. It is unclear whether objective measures of asthma control, such as pulmonary function tests... Read More about Persistent ventilation inhomogeneity after an acute exacerbation in preschool children with recurrent wheezing.

Predictive value of blood eosinophils and exhaled nitric oxide in adults with mild asthma: a prespecified subgroup analysis of an open-label, parallel-group, randomised controlled trial (2020)
Journal Article
Pavord, I. D., Holliday, M., Reddel, H. K., Braithwaite, I., Ebmeier, S., Hancox, R. J., …Toelle, B. (2020). Predictive value of blood eosinophils and exhaled nitric oxide in adults with mild asthma: a prespecified subgroup analysis of an open-label, parallel-group, randomised controlled trial. Lancet Respiratory Medicine, 8(7), 671-680. https://doi.org/10.1016/s2213-2600%2820%2930053-9

Background Whether blood eosinophil counts and exhaled nitric oxide (FeNO) are associated with important outcomes in mild asthma is unclear. In this prespecified subgroup analysis of a previously published open-label clinical trial, we aimed to asse... Read More about Predictive value of blood eosinophils and exhaled nitric oxide in adults with mild asthma: a prespecified subgroup analysis of an open-label, parallel-group, randomised controlled trial.

A retrospective database study of oral corticosteroid and bisphosphonate prescribing patterns in England (2020)
Journal Article
Chalitsios, C. V., Chalitsios, C. V., Shaw, D. E., & McKeever, T. M. (2020). A retrospective database study of oral corticosteroid and bisphosphonate prescribing patterns in England. npj Primary Care Respiratory Medicine, 30(1), https://doi.org/10.1038/s41533-020-0162-6

© 2020, The Author(s). Exposure to oral corticosteroids (OCS) is associated with an increased risk of osteoporosis and fragility fractures. Guidelines suggest bisphosphonate (BP) therapy as the first-line treatment of glucocorticoid-induced osteoporo... Read More about A retrospective database study of oral corticosteroid and bisphosphonate prescribing patterns in England.

Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study (2020)
Journal Article
Fermont, J. M., Bolton, C. E., Fisk, M., Mohan, D., Macnee, W., Cockcroft, J. R., …Müllerova, H. (2020). Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study. PLoS ONE, 15(2), e0228940. https://doi.org/10.1371/journal.pone.0228940

In chronic obstructive pulmonary disease (COPD), acute exacerbation of COPD requiring hospital admission is associated with mortality and healthcare costs. The ERICA study assessed multiple clinical measures in people with COPD, including the short... Read More about Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study.

Repurposing Antibacterial AM404 as a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells (2019)
Journal Article
Ahmed, M., Jinks, N., Babaei-Jadidi, R., Kashfi, H., Castellanos-Uribe, M., May, S. T., …Nateri, A. S. (2019). Repurposing Antibacterial AM404 as a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells. Cancers, 12(1), Article 106. https://doi.org/10.3390/cancers12010106

Tumour-promoting inflammation is involved in colorectal cancer (CRC) development and therapeutic resistance. However, the antibiotics and antibacterial drugs and signalling that regulate the potency of anticancer treatment upon forced differentiation... Read More about Repurposing Antibacterial AM404 as a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells.