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Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study

Fermont, Jilles M; Bolton, Charlotte E.; Fisk, Marie; Mohan, Divya; Macnee, William; Cockcroft, John R.; McEniery, Carmel; Fuld, Jonathan; Cheriyan, Joseph; Tal-Singer, Ruth; Wilkinson, Ian B; Wood, Angela M; Polkey, Michael I; M�llerova, Hana

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Authors

Jilles M Fermont

Marie Fisk

Divya Mohan

William Macnee

John R. Cockcroft

Carmel McEniery

Jonathan Fuld

Joseph Cheriyan

Ruth Tal-Singer

Ian B Wilkinson

Angela M Wood

Michael I Polkey

Hana M�llerova



Contributors

Stelios Loukides
Editor

Abstract

In chronic obstructive pulmonary disease (COPD), acute exacerbation of COPD requiring hospital admission is associated with mortality and healthcare costs. The ERICA study assessed multiple clinical measures in people with COPD, including the short physical performance battery (SPPB), a simple test of physical function with 3 components (gait speed, balance and sit-to-stand). We tested the hypothesis that SPPB score would relate to risk of hospital admissions and length of hospital stay. Data were analysed from 714 of the total 729 participants (434 men and 280 women) with COPD. Data from this prospective observational longitudinal study were obtained from 4 secondary and 1 tertiary centres from England, Scotland, and Wales. The main outcome measures were to estimate the risk of hospitalisation with acute exacerbation of COPD (AECOPD and length of hospital stay derived from hospital episode statistics (HES). In total, 291 of 714 individuals experienced 762 hospitalised AECOPD during five-year follow up. Poorer performance of SPPB was associated with both higher rate (IRR 1.08 per 1 point decrease, 95% CI 1.01 to 1.14) and increased length of stay (IRR 1.18 per 1 point decrease, 95% CI 1.10 to 1.27) for hospitalised AECOPD. For the individual sit-to-stand component of the SPPB, the association was even stronger (IRR 1.14, 95% CI 1.02 to 1.26 for rate and IRR 1.32, 95% CI 1.16 to 1.49 for length of stay for hospitalised AECOPD). The SPPB, and in particular the sit-to-stand component can both evaluate the risk of H-AECOPD and length of hospital stay in COPD. The SPPB can aid in clinical decision making and when prioritising healthcare resources.

Citation

Fermont, J. M., Bolton, C. E., Fisk, M., Mohan, D., Macnee, W., Cockcroft, J. R., …Müllerova, H. (2020). Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study. PLoS ONE, 15(2), e0228940. https://doi.org/10.1371/journal.pone.0228940

Journal Article Type Article
Acceptance Date Jan 28, 2020
Online Publication Date Feb 10, 2020
Publication Date Feb 10, 2020
Deposit Date Feb 6, 2020
Publicly Available Date Mar 28, 2024
Journal PLoS ONE
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 15
Issue 2
Article Number e0228940
Pages e0228940
DOI https://doi.org/10.1371/journal.pone.0228940
Keywords General Biochemistry, Genetics and Molecular Biology; General Agricultural and Biological Sciences; General Medicine
Public URL https://nottingham-repository.worktribe.com/output/3905354
Publisher URL https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228940

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