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Reducing antimicrobial use on dairy farms using a herd health approach (2019)
Journal Article
Hyde, R., Tisdall, D., Gordon, P., & Remnant, J. (2019). Reducing antimicrobial use on dairy farms using a herd health approach. In Practice, 41(8), 368-382. https://doi.org/10.1136/inp.l5518

Background: There has been much scrutiny of antimicrobial use in the livestock sector, since the O’Neill report, a 2015 government -commissioned review of antimicrobial resistance, called for the agriculture industry to reduce its use of antimicrobia... Read More about Reducing antimicrobial use on dairy farms using a herd health approach.

What Makes a Rabbit Cute? Preference for Rabbit Faces Differs according to Skull Morphology and Demographic Factors (2019)
Journal Article
Harvey, N. D., Oxley, J. A., Miguel-Pacheco, G., Gosling, E. M., & Farnworth, M. (2019). What Makes a Rabbit Cute? Preference for Rabbit Faces Differs according to Skull Morphology and Demographic Factors. Animals, 9(10), Article 728. https://doi.org/10.3390/ani9100728

Domesticated rabbits typically exhibit shorter, flatter skulls than their wild counterparts (brachycephalism). However, brachycephaly is associated with considerable health problems, including problems with dentition. The aim of this study was to est... Read More about What Makes a Rabbit Cute? Preference for Rabbit Faces Differs according to Skull Morphology and Demographic Factors.

Do UK sheep farmers use orf vaccine correctly and could their vaccination strategy affect vaccine efficacy? (2019)
Journal Article
Small, S., Cresswell, L., Lovatt, F., Gummery, E., Onyango, J., McQuilkin, C., & Wapenaar, W. (2019). Do UK sheep farmers use orf vaccine correctly and could their vaccination strategy affect vaccine efficacy?. Veterinary Record, 185(10), 305. https://doi.org/10.1136/vr.105472

© British Veterinary Association 2019. No commercial re-use. See rights and permissions. Published by BMJ. Orf, a parapoxvirus, is a zoonosis causing a contagious pustular dermatitis, and has a high morbidity in sheep worldwide. Despite a vaccine bei... Read More about Do UK sheep farmers use orf vaccine correctly and could their vaccination strategy affect vaccine efficacy?.

Serum metabolomic alterations in Beagle dogs experimentally infected with Toxocara canis (2019)
Journal Article
Zou, Y., Zheng, W.-B., Elsheikha, H. M., Liu, G.-H., Hu, M.-H., Wang, S.-L., & Zhu, X.-Q. (2019). Serum metabolomic alterations in Beagle dogs experimentally infected with Toxocara canis. Parasites and Vectors, 12(1), 1-10. https://doi.org/10.1186/s13071-019-3703-5

Background
Toxocara canis, a globally distributed roundworm, can cause debilitating disease in dogs and humans; however, little is known about the metabolomic response of the hosts to T. canis infection. There is an increasing need to understand the... Read More about Serum metabolomic alterations in Beagle dogs experimentally infected with Toxocara canis.

Dealing with maedi visna in UK sheep flocks (2019)
Journal Article
Ogden, N., Davies, P., & Lovatt, F. (2019). Dealing with maedi visna in UK sheep flocks. In Practice, 41(7), 321-328. https://doi.org/10.1136/inp.l4838

Background: Maedi visna (MV) is considered to be one of the ‘iceberg diseases’ of sheep; a group of infectious, production-limiting diseases which are endemic to the UK. Characterised by slow, progressive onset, these diseases lie undetected and can... Read More about Dealing with maedi visna in UK sheep flocks.

Sex pilus specific bateriophage to drive bacterial population towards antibiotic sensitivity (2019)
Journal Article
Colom, J., Batista, D., Baig, A., Tang, Y., Liu, S., Yuan, F., Belkhiri, A., Marcelino, L., Barbosa, F., Rubio, M., Atterbury, R., Berchieri, A., Onuigbo, E., & Barrow, P. (2019). Sex pilus specific bateriophage to drive bacterial population towards antibiotic sensitivity. Scientific Reports, 9, 1-11. https://doi.org/10.1038/s41598-019-48483-9

Antimicrobial resistance (AMR) is now a major global problem largely resulting from the overuse of antibiotics in humans and livestock. In some AMR bacteria, resistance is encoded by conjugative plasmids expressing sex-pili that can readily spread re... Read More about Sex pilus specific bateriophage to drive bacterial population towards antibiotic sensitivity.

Advances in the Production and Batch Reformatting of Phage Antibody Libraries (2019)
Journal Article
Reader, R. H., Workman, R. G., Maddison, B. C., & Gough, K. C. (2019). Advances in the Production and Batch Reformatting of Phage Antibody Libraries. Molecular Biotechnology, 61, 801-815. https://doi.org/10.1007/s12033-019-00207-0

Phage display antibody libraries have proven an invaluable resource for the isolation of diagnostic and potentially therapeutic antibodies, the latter usually being antibody fragments converted into IgG formats. Recent advances in the production of h... Read More about Advances in the Production and Batch Reformatting of Phage Antibody Libraries.

iTRAQ-Based Global Phosphoproteomics Reveals Novel Molecular Differences Between Toxoplasma gondii Strains of Different Genotypes (2019)
Journal Article
Wang, Z.-X., Zhou, C.-X., Calderón-Mantilla, G., Petsalaki, E., He, J.-J., Song, H.-Y., Elsheikha, H. M., & Zhu, X.-Q. (2019). iTRAQ-Based Global Phosphoproteomics Reveals Novel Molecular Differences Between Toxoplasma gondii Strains of Different Genotypes. Frontiers in Cellular and Infection Microbiology, 9, 1-19. https://doi.org/10.3389/fcimb.2019.00307

To gain insights into differences in the virulence among T. gondii strains at the post-translational level, we conducted a quantitative analysis of the phosphoproteome profile of T. gondii strains belonging to three different genotypes. Phosphopeptid... Read More about iTRAQ-Based Global Phosphoproteomics Reveals Novel Molecular Differences Between Toxoplasma gondii Strains of Different Genotypes.

Developing and evaluating threshold-based algorithms to detect drinking behavior in dairy cows using reticulorumen temperature (2019)
Journal Article
Vázquez-Diosdado, J., Miguel-Pacheco, G., Plant, B., Dottorini, T., Green, M., & Kaler, J. (2019). Developing and evaluating threshold-based algorithms to detect drinking behavior in dairy cows using reticulorumen temperature. Journal of Dairy Science, 102(11), 10471-10482. https://doi.org/10.3168/jds.2019-16442

© 2019 American Dairy Science Association In this study, we assessed for the first time the use of a reticuloruminal temperature bolus and a thresholding method to detect drinking events and investigated different factors that can affect drinking beh... Read More about Developing and evaluating threshold-based algorithms to detect drinking behavior in dairy cows using reticulorumen temperature.

Development of a comprehensive protein microarray for immunoglobulin E profiling in horses with severe asthma (2019)
Journal Article
Moore‐Colyer, M., White, S., Moore-Colyer, M., Marti, E., Coüetil, L., Hannant, D., Richard, E. A., & Alcocer, M. (2019). Development of a comprehensive protein microarray for immunoglobulin E profiling in horses with severe asthma. Journal of Veterinary Internal Medicine, 33(5), 2327-2335. https://doi.org/10.1111/jvim.15564

Background
Severe asthma in horses, known as severe equine asthma (SEA), is a prevalent, performance‐limiting disease associated with increased allergen‐specific immunoglobulin E (IgE) against a range of environmental aeroallergens.

Objective
To... Read More about Development of a comprehensive protein microarray for immunoglobulin E profiling in horses with severe asthma.

Association of lameness and mastitis with return-to-service oestrus detection in the dairy cow (2019)
Journal Article
Remnant, J., Green, M. J., Huxley, J., Roberts, G., Jones, R., Hirst-Beecham, J., & Hudson, C. D. (2019). Association of lameness and mastitis with return-to-service oestrus detection in the dairy cow. Veterinary Record, 185(14), 442. https://doi.org/10.1136/vr.105535

© British Veterinary Association 2019. No commercial re-use. See rights and permissions. Published by BMJ. Oestrus detection is an important part of maintaining efficient reproductive performance in dairy herds. Both lameness and mastitis are common... Read More about Association of lameness and mastitis with return-to-service oestrus detection in the dairy cow.

Imaging features of discospondylitis in cats (2019)
Journal Article
Garosi, L. S., Gomes, S. A., Gomes, S. A., Behr, S., Garosi, L. S., Carrera, I., Targett, M., & Lowrie, M. (2020). Imaging features of discospondylitis in cats. Journal of Feline Medicine and Surgery, 22(7), 631-640. https://doi.org/10.1177/1098612X19869705

Objectives
This study describes the imaging features of feline discospondylitis on MRI, comparing them to CT and radiographic findings where available.

Methods
The medical records of cats diagnosed with discospondylitis, presented to three refer... Read More about Imaging features of discospondylitis in cats.

Environmental risk factors for canine atopic dermatitis: a retrospective large‐scale study in Labrador and golden retrievers (2019)
Journal Article
Harvey, N. D., Shaw, S. C., Craigon, P. J., Blott, S. C., & England, G. C. (2019). Environmental risk factors for canine atopic dermatitis: a retrospective large‐scale study in Labrador and golden retrievers. Veterinary Dermatology, 30(5), 396-e119. https://doi.org/10.1111/vde.12782

Background - canine atopic dermatitis (cAD) is one the most common and distressing skin disorders seen in dogs. It is characterised by dysfunction in the skin barrier, with a complex pathogenesis combining both genetic and environmental factors.

O... Read More about Environmental risk factors for canine atopic dermatitis: a retrospective large‐scale study in Labrador and golden retrievers.

Immunomodulation by vasoactive intestinal peptide is associated with increased survival and growth of Salmonella Typhimurium in mice (2019)
Journal Article
Askar, B., Higgins, J., Barrow, P., & Foster, N. (2020). Immunomodulation by vasoactive intestinal peptide is associated with increased survival and growth of Salmonella Typhimurium in mice. Cytokine, 125, Article 154787. https://doi.org/10.1016/j.cyto.2019.154787

© 2019 Elsevier Ltd Studies have shown that administration of vasoactive intestinal peptide (VIP) in mice rescues them from lethal endotoxaemia and that this is correlated with decreased concentration of inflammatory cytokines. VIP has, therefore, be... Read More about Immunomodulation by vasoactive intestinal peptide is associated with increased survival and growth of Salmonella Typhimurium in mice.

Equine viral encephalitis: prevalence, impact, and management strategies (2019)
Journal Article
Barba, M., Fairbanks, E., & Daly, J. M. (2019). Equine viral encephalitis: prevalence, impact, and management strategies. Veterinary Medicine: Research and Reports, 2019(10), 99-110. https://doi.org/10.2147/VMRR.S168227

Members of several different virus families cause equine viral encephalitis, the majority of which are arthropod-borne viruses (arboviruses) with zoonotic potential. The clinical signs caused are rarely pathognomonic; therefore, a clinical diagnosis... Read More about Equine viral encephalitis: prevalence, impact, and management strategies.

Sulfadiazine Sodium Ameliorates the Metabolomic Perturbation in Mice Infected with Toxoplasma gondii (2019)
Journal Article
Zhu, X.-Q., Zhou, C.-X., Liu, Q., Gan, Y., Cong, H., Elsheikha, H. M., & Chen, X.-Q. (2019). Sulfadiazine Sodium Ameliorates the Metabolomic Perturbation in Mice Infected with Toxoplasma gondii. Antimicrobial Agents and Chemotherapy, 63(10), Article e00312-19. https://doi.org/10.1128/AAC.00312-19

In this study, we analyzed the global metabolomic changes associated with Toxoplasma gondii infection in mice in the presence or absence of sulfadiazine sodium (SDZ) treatment. BALB/c mice were infected with T. gondii GT1 strain and treated orally wi... Read More about Sulfadiazine Sodium Ameliorates the Metabolomic Perturbation in Mice Infected with Toxoplasma gondii.

Lentiviral-Mediated shRNA Approaches: Applications in Cellular Differentiation and Autophagy (2019)
Book Chapter
Orfali, N., Jeyapalan, J. N., Woodcock, C. L., O’Donovan, T. R., Benjamin, D., Cahill, M., McKenna, S., Gudas, L. J., & Mongan, N. P. (2019). Lentiviral-Mediated shRNA Approaches: Applications in Cellular Differentiation and Autophagy. In Retinoid and Rexinoid Signaling (33-49). Humana Press. https://doi.org/10.1007/978-1-4939-9585-1_3

Acute myeloid leukemia (AML) is characterized by the accumulation of immature white blood cell precursors in the bone marrow and peripheral circulation. In essence, leukemic cells fail to differentiate and are stalled at a particular step of hematopo... Read More about Lentiviral-Mediated shRNA Approaches: Applications in Cellular Differentiation and Autophagy.

Metabolomic signature of mouse cerebral cortex following Toxoplasma gondii infection (2019)
Journal Article
Ma, J., He, J.-J., Hou, J.-L., Zhou, C.-X., Zhang, F.-K., Elsheikha, H. M., & Zhu, X.-Q. (2019). Metabolomic signature of mouse cerebral cortex following Toxoplasma gondii infection. Parasites and Vectors, 12, 1-11. https://doi.org/10.1186/s13071-019-3623-4

Background: The protozoan parasite Toxoplasma gondii infects and alters the neurotransmission in cerebral cortex and other brain regions, leading to neurobehavioral and neuropathologic changes in humans and animals. However, the molecules that contri... Read More about Metabolomic signature of mouse cerebral cortex following Toxoplasma gondii infection.

Genetic diversity of Koala retrovirus env gene subtypes: insights into northern and southern koala populations (2019)
Journal Article
Sarker, N., Fabijan, J., Seddon, J., Tarlinton, R., Owen, H., Simmons, G., Thia, J., Mark Blanchard, A., Speight, N., Kaler, J., Emes, R. D., Woolford, L., Trott, D., Hemmatzadeh, F., & Meers, J. (2019). Genetic diversity of Koala retrovirus env gene subtypes: insights into northern and southern koala populations. Journal of General Virology, 100(9), 1328-1339. https://doi.org/10.1099/jgv.0.001304

Koala retrovirus (KoRV) is a recently endogenised retrovirus associated with neoplasia and immunosuppression in koala populations. The virus is known to display sequence variability and to be present at varying prevalence in different populations, wi... Read More about Genetic diversity of Koala retrovirus env gene subtypes: insights into northern and southern koala populations.