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Sex pilus specific bateriophage to drive bacterial population towards antibiotic sensitivity

Colom, Joan; Batista, Diego; Baig, Abiyad; Tang, Ying; Liu, Siyang; Yuan, Fangzhong; Belkhiri, Aoutif; Marcelino, Lucas; Barbosa, Fernanda; Rubio, Marcela; Atterbury, Robert; Berchieri, Angelo; Onuigbo, Ebele; Barrow, Paul

Authors

Joan Colom

Diego Batista

Abiyad Baig

Ying Tang

Siyang Liu

Fangzhong Yuan

Aoutif Belkhiri

Lucas Marcelino

Fernanda Barbosa

Marcela Rubio

Angelo Berchieri

Ebele Onuigbo

Paul Barrow



Abstract

Antimicrobial resistance (AMR) is now a major global problem largely resulting from the overuse of antibiotics in humans and livestock. In some AMR bacteria, resistance is encoded by conjugative plasmids expressing sex-pili that can readily spread resistance through bacterial populations. The aim of this study was to use sex pilus-specific (SPS) phage to reduce the carriage of AMR plasmids. Here, we demonstrate that SPS phage can kill AMR Escherichia coli and select for AMR plasmid loss in vitro. For the first time, we also demonstrate that SPS phage can both prevent the spread of AMR Salmonella Enteritidis infection in chickens and shift the bacterial population towards antibiotic sensitivity.

Citation

Colom, J., Batista, D., Baig, A., Tang, Y., Liu, S., Yuan, F., …Barrow, P. (2019). Sex pilus specific bateriophage to drive bacterial population towards antibiotic sensitivity. Scientific Reports, 9, 1-11. https://doi.org/10.1038/s41598-019-48483-9

Journal Article Type Article
Acceptance Date Jun 26, 2019
Online Publication Date Aug 30, 2019
Publication Date Aug 30, 2019
Deposit Date Aug 2, 2019
Publicly Available Date Mar 28, 2024
Journal Scientific Reports
Print ISSN 2045-2322
Electronic ISSN 2045-2322
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 9
Article Number 12616
Pages 1-11
DOI https://doi.org/10.1038/s41598-019-48483-9
Public URL https://nottingham-repository.worktribe.com/output/2379593
Publisher URL https://www.nature.com/articles/s41598-019-48483-9
Additional Information Received: 20 July 2018; Accepted: 24 July 2019; First Online: 30 August 2019; : The authors declare no competing interests.

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