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Predatory bacteria as living antibiotics – where are we now?

Atterbury, Robert J.; Tyson, Jess

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Authors

Jess Tyson



Abstract

Antimicrobial resistance (AMR) is a global health and economic crisis. With too few antibiotics in development to meet current and anticipated needs, there is a critical need for new therapies to treat Gram-negative infections. One potential approach is the use of living predatory bacteria, such as Bdellovibrio bacteriovorus (small Gram-negative bacteria that naturally invade and kill Gram-negative pathogens of humans, animals and plants). Moving toward the use of Bdellovibrio as a ‘living antibiotic’ demands the investigation and characterization of these bacterial predators in biologically relevant systems. We review the fundamental science supporting the feasibility of predatory bacteria as alternatives to antibiotics.

Citation

Atterbury, R. J., & Tyson, J. (2021). Predatory bacteria as living antibiotics – where are we now?. Microbiology, 167(1), Article 001025. https://doi.org/10.1099/mic.0.001025

Journal Article Type Review
Acceptance Date Jan 6, 2021
Publication Date Jan 19, 2021
Deposit Date Jun 23, 2022
Publicly Available Date Mar 29, 2024
Journal Microbiology
Print ISSN 1350-0872
Electronic ISSN 1465-2080
Publisher Microbiology Society
Peer Reviewed Peer Reviewed
Volume 167
Issue 1
Article Number 001025
DOI https://doi.org/10.1099/mic.0.001025
Keywords Microbiology
Public URL https://nottingham-repository.worktribe.com/output/5262452
Publisher URL https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.001025

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