Predatory bacteria as living antibiotics – where are we now?

Atterbury, Robert J.; Tyson, Jess

Abstract

Antimicrobial resistance (AMR) is a global health and economic crisis. With too few antibiotics in development to meet current and anticipated needs, there is a critical need for new therapies to treat Gram-negative infections. One potential approach is the use of living predatory bacteria, such as Bdellovibrio bacteriovorus (small Gram-negative bacteria that naturally invade and kill Gram-negative pathogens of humans, animals and plants). Moving toward the use of Bdellovibrio as a ‘living antibiotic’ demands the investigation and characterization of these bacterial predators in biologically relevant systems. We review the fundamental science supporting the feasibility of predatory bacteria as alternatives to antibiotics.

Citation

Atterbury, R. J., & Tyson, J. (2021). Predatory bacteria as living antibiotics – where are we now?. Microbiology, 167(1), Article 001025. https://doi.org/10.1099/mic.0.001025

• Journal Article Type: Review
• Acceptance Date: Jan 6, 2021
• Publication Date: Jan 19, 2021
• Deposit Date: Jun 23, 2022
• Publicly Available Date: Jun 24, 2022
• Journal: Microbiology
• Print ISSN: 1350-0872
• Electronic ISSN: 1465-2080
• Publisher: Microbiology Society
• Peer Reviewed: Peer Reviewed
• Volume: 167
• Issue: 1
• Article Number: 001025
• DOI: https://doi.org/10.1099/mic.0.001025
• Keywords: Microbiology
• Public URL: https://nottingham-repository.worktribe.com/output/5262452
• Publisher URL: https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.001025