Pseudomonas spp. in Canine Otitis Externa

Secker, Bailey; Shaw, Stephen; Atterbury, Robert J.

Abstract

Canine otitis externa (OE) is a commonly diagnosed condition seen in veterinary practice worldwide. In this review, we discuss the mechanisms of the disease, with a particular focus on the biological characteristics of Pseudomonas aeruginosa and the impact that antibiotic resistance has on successful recovery from OE. We also consider potential alternatives to antimicrobial chemotherapy for the treatment of recalcitrant infections. P. aeruginosa is not a typical constituent of the canine ear microbiota, but is frequently isolated from cases of chronic OE, and the nature of this pathogen often makes treatment difficult. Biofilm formation is identified in 40–95% of P. aeruginosa from cases of OE and intrinsic and acquired antibiotic resistance, especially resistance to clinically important antibiotics, highlights the need for alternative treatments. The role of other virulence factors in OE remains relatively unexplored and further work is needed. The studies described in this work highlight several potential alternative treatments, including the use of bacteriophages. This review provides a summary of the aetiology of OE with particular reference to the dysbiosis that leads to colonisation by P. aeruginosa and highlights the need for novel treatments for the future management of P. aeruginosa otitis.

Citation

Secker, B., Shaw, S., & Atterbury, R. J. (2023). Pseudomonas spp. in Canine Otitis Externa. Microorganisms, 11(11), Article 2650. https://doi.org/10.3390/microorganisms11112650

• Journal Article Type: Review
• Acceptance Date: Oct 25, 2023
• Online Publication Date: Oct 28, 2023
• Publication Date: Nov 1, 2023
• Deposit Date: Nov 7, 2023
• Publicly Available Date: Nov 7, 2023
• Journal: Microorganisms
• Electronic ISSN: 2076-2607
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 11
• Article Number: 2650
• DOI: https://doi.org/10.3390/microorganisms11112650
• Keywords: Pseudomonas; canine; otitis externa; dog; companion animal
• Public URL: https://nottingham-repository.worktribe.com/output/27075443
• Publisher URL: https://www.mdpi.com/2076-2607/11/11/2650