All Outputs (119)

Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation (2019)
Journal Article
Gomzikova, M. O., James, V., & Rizvanov, A. A. (2019). Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation. Frontiers in Immunology, 10, Article 2663. https://doi.org/10.3389/fimmu.2019.02663

The immunosuppressive potential of mesenchymal stem cells has been extensively investigated in many studies in vivo and in vitro. In recent years, a variety preclinical and clinical studies have demonstrated that mesenchymal stem cells ameliorate imm... Read More about Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation.

Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk (2019)
Journal Article
Es-Haghi, M., Godakumara, K., Häling, A., Lättekivi, F., Lavrits, A., Viil, J., Andronowska, A., Nafee, T., James, V., Jaakma, Ü., Salumets, A., & Fazeli, A. (2019). Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk. Cell Communication and Signaling, 17(1), Article 146. https://doi.org/10.1186/s12964-019-0448-x

© 2019 The Author(s). Background: Successful establishment of pregnancy hinges on appropriate communication between the embryo and the uterus prior to implantation, but the nature of this communication remains poorly understood. Here, we tested the h... Read More about Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk.

Induction and measurement of the early stage of a host-parasite interaction using a combined optical trapping and Raman microspectroscopy system (2019)
Journal Article
Sinjab, F., Elsheikha, H. M., Dooley, M., & Notingher, I. (2020). Induction and measurement of the early stage of a host-parasite interaction using a combined optical trapping and Raman microspectroscopy system. Journal of Biophotonics, 13(2), Article e201960065. https://doi.org/10.1002/jbio.201960065

© 2019 The Authors. Journal of Biophotonics published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Understanding and quantifying the temporal acquisition of host cell molecules by intracellular pathogens is fundamentally important in biology. In t... Read More about Induction and measurement of the early stage of a host-parasite interaction using a combined optical trapping and Raman microspectroscopy system.

Sustainable lamb production: Evaluation of factors affecting lamb growth using hierarchical, cross classified and multiple memberships models (2019)
Journal Article
Lima, E., Lovatt, F., Green, M., Roden, J., Davies, P., & Kaler, J. (2020). Sustainable lamb production: Evaluation of factors affecting lamb growth using hierarchical, cross classified and multiple memberships models. Preventive Veterinary Medicine, 174, Article 104822. https://doi.org/10.1016/j.prevetmed.2019.104822

© 2019 Elsevier B.V. In light of current concerns about the sustainability of red meat production in a world with increasing global demand for food from animal origin there is a need for a better understanding of factors that influence the growth rat... Read More about Sustainable lamb production: Evaluation of factors affecting lamb growth using hierarchical, cross classified and multiple memberships models.

Production and Application of Multicistronic Constructs for Various Human Disease Therapies (2019)
Journal Article
Shaimardanova, A. A., Kitaeva, K. V., Abdrakhmanova, I. I., Chernov, V. M., Rutland, C. S., Rizvanov, A. A., Chulpanova, D. S., & Solovyeva, V. V. (2019). Production and Application of Multicistronic Constructs for Various Human Disease Therapies. Pharmaceutics, 11, 580. https://doi.org/10.3390/pharmaceutics11110580

The development of multicistronic vectors has opened up new opportunities to address the fundamental issues of molecular and cellular biology related to the need for the simultaneous delivery and joint expression of several genes. To date, the exampl... Read More about Production and Application of Multicistronic Constructs for Various Human Disease Therapies.

Label-Free Quantitative Acetylome Analysis Reveals Toxoplasma gondii Genotype-Specific Acetylomic Signatures (2019)
Journal Article
Wang, Z.-X., Hu, R.-S., Zhou, C.-X., He, J.-J., M. Elsheikha, H., & Zhu, X.-Q. (2019). Label-Free Quantitative Acetylome Analysis Reveals Toxoplasma gondii Genotype-Specific Acetylomic Signatures. Microorganisms, 7(11), 1-19. https://doi.org/10.3390/microorganisms7110510

Distinct genotypic and pathogenic differences exist between Toxoplasma gondii genotypes. For example, genotype I is highly virulent, whereas genotype II and genotype III are less virulent. Moreover, Chinese 1 genotype (ToxoDB#9) is also virulent. Her... Read More about Label-Free Quantitative Acetylome Analysis Reveals Toxoplasma gondii Genotype-Specific Acetylomic Signatures.

Animals, veterinarians and the sociology of diagnosis (2019)
Journal Article
Hobson‐West, P., & Jutel, A.-M. (2020). Animals, veterinarians and the sociology of diagnosis. Sociology of Health and Illness, 42(2), 393-406. https://doi.org/10.1111/1467-9566.13017

While sociologists of medicine have focused their efforts on understanding human health, illness, and medicine, veterinary medical practice has not yet caught their attention in any sustained way. In this critical review paper, we use insights from t... Read More about Animals, veterinarians and the sociology of diagnosis.

Author Correction: The Beta-adrenergic agonist, Ractopamine, increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program (2019)
Journal Article
Brown, D., Ryan, K., Daniel, Z., Mareko, M., Talbot, R., Moreton, J., Giles, T. C., Emes, R., Hodgman, C., Parr, T., & Brameld, J. M. (2019). Author Correction: The Beta-adrenergic agonist, Ractopamine, increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program. Scientific Reports, 9(1), Article 15412. https://doi.org/10.1038/s41598-019-43807-1

© 2019, The Author(s). In the Supplementary Information file originally published with this Article, Table 2 was omitted. This error has been corrected in the Supplementary Information that now accompanies the Article.

Appointment scheduling and cost in first opinion small animal practice (2019)
Journal Article
Corah, L., Lambert, A., Cobb, K., & Mossop, L. (2019). Appointment scheduling and cost in first opinion small animal practice. Heliyon, 5(10), Article e02567. https://doi.org/10.1016/j.heliyon.2019.e02567

Approximately half of first opinion, small animal consultations exceed their allocated time and there's a growing call in the UK for longer consults. The aim of this study was to investigate and describe allocated appointment length in first opinion,... Read More about Appointment scheduling and cost in first opinion small animal practice.

Potential therapeutic application of mesenchymal stem cells in ophthalmology (2019)
Journal Article
Zakirova, E. Y., Valeeva, A., Aimaletdinov, A., Nefedovskaya, L., Akhmetshin, R., Rutland, C., & Rizvanov, A. (2019). Potential therapeutic application of mesenchymal stem cells in ophthalmology. Experimental Eye Research, 189, Article 107863. https://doi.org/10.1016/j.exer.2019.107863

At present a wide variety of methods have been proposed to treat eye disorders, drug therapies are most commonly used. It should be noted that effective treatment modalities especially for degeneration of the retina and optic nerve are lacking. In th... Read More about Potential therapeutic application of mesenchymal stem cells in ophthalmology.

Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells (2019)
Journal Article
Brearley, M. C., Li, C., Daniel, Z. C., Loughna, P. T., Parr, T., & Brameld, J. M. (2019). Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells. Biochemistry and Biophysics Reports, 20, Article 100694. https://doi.org/10.1016/j.bbrep.2019.100694

Skeletal muscle is a highly metabolic and dynamic tissue that is formed through the complex and well-organised process of myogenesis. Although there is a good understanding about the role of the Muscle Regulatory Factors during myogenesis, little is... Read More about Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells.

Antigen array for serological diagnosis and novel allergen identification in severe equine asthma (2019)
Journal Article
White, S. J., Moore-Colyer, M., Marti, E., Hannant, D., Gerber, V., Coüetil, L., Richard, E. A., & Alcocer, M. (2019). Antigen array for serological diagnosis and novel allergen identification in severe equine asthma. Scientific Reports, 9, Article 15170. https://doi.org/10.1038/s41598-019-51820-7

Severe equine asthma (sEA), which closely resembles human asthma, is a debilitating and performance-limiting allergic respiratory disorder which affects 14% of horses in the Northern Hemisphere and is associated with increased allergen-specific immun... Read More about Antigen array for serological diagnosis and novel allergen identification in severe equine asthma.

555 Questions in Veterinary and Tropical Parasitology (2019)
Book
Elsheikha, H., & Zhu, X.-Q. (2019). 555 Questions in Veterinary and Tropical Parasitology. CAB International

Parasites are a major issue affecting animal and human health, welfare, and economic productivity. This book provides 555 questions to test your knowledge of animal and tropical parasitology, to help you study anywhere, with any amount of time. Key f... Read More about 555 Questions in Veterinary and Tropical Parasitology.

Extracellular vesicles in the diagnosis and treatment of central nervous system diseases (2019)
Journal Article
Shaimardanova, A. A., Solovyeva, V. V., Chulpanova, D. S., James, V., Kitaeva, K. V., & Rizvanov, A. A. (2020). Extracellular vesicles in the diagnosis and treatment of central nervous system diseases. Neural Regeneration Research, 15(4), 586=596. https://doi.org/10.4103/1673-5374.266908

Extracellular vesicles, exosomes and microvesicles, play a fundamental role in the activity of the nervous system, participating in signal transmission between neurons and providing the interaction of central nervous system (CNS) with all body system... Read More about Extracellular vesicles in the diagnosis and treatment of central nervous system diseases.

Behavioural Differences in Dogs with Atopic Dermatitis Suggest Stress Could Be a Significant Problem Associated with Chronic Pruritus (2019)
Journal Article
Harvey, N. D., Craigon, P. J., Shaw, S. C., Blott, S. C., & England, G. C. (2019). Behavioural Differences in Dogs with Atopic Dermatitis Suggest Stress Could Be a Significant Problem Associated with Chronic Pruritus. Animals, 9(10), Article 813. https://doi.org/10.3390/ani9100813

Canine atopic dermatitis (cAD) is a common allergic skin condition in dogs that causes chronic pruritus. The overall quality of life in dogs with cAD is known to be reduced, and human patients with pruritic conditions report significant psychological... Read More about Behavioural Differences in Dogs with Atopic Dermatitis Suggest Stress Could Be a Significant Problem Associated with Chronic Pruritus.

Vaccination of foals with a modified live, equid herpesvirus-1 gM deletion mutant (RacHΔgM) confers partial protection against infection (2019)
Journal Article
Kydd, J. H., Hannant, D., Robinson, R. S., Bryant, N., & Osterrieder, N. (2020). Vaccination of foals with a modified live, equid herpesvirus-1 gM deletion mutant (RacHΔgM) confers partial protection against infection. Vaccine, 38(2), 388-398. https://doi.org/10.1016/j.vaccine.2019.09.106

Equid herpesvirus-1 (EHV-1) causes respiratory and neurological disease and late gestation abortion in pregnant mares. Current vaccines contain either inactivated or live EHV-1, but fail to provide complete clinical or virological protection, namely... Read More about Vaccination of foals with a modified live, equid herpesvirus-1 gM deletion mutant (RacHΔgM) confers partial protection against infection.

Complex and dynamic transcriptional changes allow the helminth Fasciola gigantica to adjust to its intermediate snail and definitive mammalian hosts (2019)
Journal Article
Zhang, X.-X., Cwiklinski, K., Hu, R.-S., Zheng, W.-B., Sheng, Z.-A., Zhang, F.-K., Elsheikha, H. M., Dalton, J. P., & Zhu, X.-Q. (2019). Complex and dynamic transcriptional changes allow the helminth Fasciola gigantica to adjust to its intermediate snail and definitive mammalian hosts. BMC Genomics, 20, 1-18. https://doi.org/10.1186/s12864-019-6103-5

Background
The tropical liver fluke, Fasciola gigantica causes fasciolosis, an important disease of humans and livestock. We characterized dynamic transcriptional changes associated with the development of the parasite in its two hosts, the snail in... Read More about Complex and dynamic transcriptional changes allow the helminth Fasciola gigantica to adjust to its intermediate snail and definitive mammalian hosts.

A reconnaissance survey of farmers’ awareness of hypomagnesaemic tetany in UK cattle and sheep farms (2019)
Journal Article
Kumssa, D. B., Penrose, B., Bone, P. A., Lovatt, A., Broadley, M. R., Kendall, N. R., & Ander, L. (2019). A reconnaissance survey of farmers’ awareness of hypomagnesaemic tetany in UK cattle and sheep farms. PLoS ONE, 14(10), Article e022386. https://doi.org/10.1371/journal.pone.0223868

Hypomagnesaemic tetany (HypoMgT) in ruminants is a physiological disorder caused by inadequate intake or impaired absorption of magnesium (Mg) in the gut. If it is not detected and treated in time, HypoMgT can cause the death of the affected animal.... Read More about A reconnaissance survey of farmers’ awareness of hypomagnesaemic tetany in UK cattle and sheep farms.

The prognostic significance of wild type isocitrate dehydrogenase 2 (IDH2) in breast cancer (2019)
Journal Article
Aljohani, A. I., Toss, M. S., Kurozumi, S., Joseph, C., Aleskandarany, M. A., Miligy, I. M., Ansari, R. E., Mongan, N. P., Ellis, I. O., Green, A. R., & Rakha, E. (2020). The prognostic significance of wild type isocitrate dehydrogenase 2 (IDH2) in breast cancer. Breast Cancer Research and Treatment, 179(1), 79–90. https://doi.org/10.1007/s10549-019-05459-7

Background: Lymphovascular invasion (LVI) is a prerequisite step in breast cancer (BC) metastasis. We have previously identified wild type isocitrate dehydrogenase 2 (IDH2) as a key putative driver of LVI. Thus, we explored the prognostic significanc... Read More about The prognostic significance of wild type isocitrate dehydrogenase 2 (IDH2) in breast cancer.

Sites of persistence of Fusobacterium necrophorum and Dichelobacter nodosus: a paradigm shift in understanding the epidemiology of footrot in sheep (2019)
Journal Article
Clifton, R., Giebel, K., Liu, N. L., Purdy, K. J., & Green, L. E. (2019). Sites of persistence of Fusobacterium necrophorum and Dichelobacter nodosus: a paradigm shift in understanding the epidemiology of footrot in sheep. Scientific Reports, 9, Article 14429. https://doi.org/10.1038/s41598-019-50822-9

Sites of persistence of bacterial pathogens contribute to disease dynamics of bacterial diseases. Footrot is a globally important bacterial disease that reduces health and productivity of sheep. It is caused by Dichelobacter nodosus, a pathogen appar... Read More about Sites of persistence of Fusobacterium necrophorum and Dichelobacter nodosus: a paradigm shift in understanding the epidemiology of footrot in sheep.