Potential therapeutic application of mesenchymal stem cells in ophthalmology

Zakirova, E. Yu; Valeeva, A.N.; Aimaletdinov, A.M.; Nefedovskaya, L.V.; Akhmetshin, R.F.; Rutland, C.S.; Rizvanov, A.A.

Abstract

At present a wide variety of methods have been proposed to treat eye disorders, drug therapies are most commonly used. It should be noted that effective treatment modalities especially for degeneration of the retina and optic nerve are lacking. In the last few years stem cell transplantation has been proposed as an alternative method. The opportunities that stem cells provide within clinical use are almost unlimited. These cells are presently applied to treat various traumatic and degenerative disorders due to their unique biologic properties. Stem cells have high proliferative capabilities and are a self-maintained population of cells capable of differentiating into different cell types. Thus, they are represent a very primary stage of a cell lineage. Their ability to differentiate into different pathways provides animals with great plasticity in the renewal of somatic cells in postnatal ontogenesis. Pre-clinical and clinical ophthalmology studies where mesenchymal stem cells are applied and various methods of their administration are discussed herein. In addition the safety and efficacy of using bone marrow- and adipose tissue-derived mesenchymal stem cells have been discussed.

• Journal Article Type: Article
• Acceptance Date: Oct 23, 2019
• Online Publication Date: Oct 24, 2019
• Publication Date: 2019-12
• Deposit Date: Oct 31, 2019
• Publicly Available Date: Oct 25, 2020
• Journal: Experimental Eye Research
• Print ISSN: 0014-4835
• Electronic ISSN: 1096-0007
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 189
• Article Number: 107863
• DOI: https://doi.org/10.1016/j.exer.2019.107863
• Keywords: Ophthalmology; Sensory Systems; Cellular and Molecular Neuroscience
• Public URL: https://nottingham-repository.worktribe.com/output/3000624
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0014483519304737