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Genetics of human and canine dilated cardiomyopathy

Simpson, Siobhan; Edwards, Jennifer; Ferguson-Mignan, Thomas F.N.; Cobb, Malcolm; Mongan, Nigel P.; Rutland, Catrin S.

Authors

Siobhan Simpson

Jennifer Edwards

Thomas F.N. Ferguson-Mignan

MALCOLM COBB malcolm.cobb@nottingham.ac.uk
Professor of Comparative Veterinary Medicine



Abstract

Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than 50 genetic loci associated with the disease. Despite canine DCM having similar disease progression to human DCM studies into the genetic basis of canine DCM lag far behind those of human DCM. In this review the aetiology, epidemiology, and clinical characteristics of canine DCM are examined, along with highlighting possible different subtypes of canine DCM and their potential relevance to human DCM. Finally the current position of genetic research into canine and human DCM, including the genetic loci, is identified and the reasons many studies may have failed to find a genetic association with canine DCM are reviewed.

Journal Article Type Article
Publication Date Jun 23, 2015
Journal International Journal of Genomics
Print ISSN 2314-436X
Electronic ISSN 2314-436X
Publisher Hindawi Publishing Corporation
Peer Reviewed Peer Reviewed
Volume 2015
Article Number 204823
APA6 Citation Simpson, S., Edwards, J., Ferguson-Mignan, T. F., Cobb, M., Mongan, N. P., & Rutland, C. S. (2015). Genetics of human and canine dilated cardiomyopathy. International Journal of Genomics, 2015, https://doi.org/10.1155/2015/204823
DOI https://doi.org/10.1155/2015/204823
Keywords cardiovascular disease, dilated cardiomyopathy
Publisher URL http://www.hindawi.com/journals/ijg/2015/204823/
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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