Genetics of human and canine dilated cardiomyopathy
Simpson, Siobhan; Edwards, Jennifer; Ferguson-Mignan, Thomas F.N.; Cobb, Malcolm; Mongan, Nigel P.; Rutland, Catrin S.
Thomas F.N. Ferguson-Mignan
MALCOLM COBB firstname.lastname@example.org
Professor of Comparative Veterinary Medicine
NIGEL MONGAN email@example.com
Professor of Oncology
CATRIN RUTLAND firstname.lastname@example.org
Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than 50 genetic loci associated with the disease. Despite canine DCM having similar disease progression to human DCM studies into the genetic basis of canine DCM lag far behind those of human DCM. In this review the aetiology, epidemiology, and clinical characteristics of canine DCM are examined, along with highlighting possible different subtypes of canine DCM and their potential relevance to human DCM. Finally the current position of genetic research into canine and human DCM, including the genetic loci, is identified and the reasons many studies may have failed to find a genetic association with canine DCM are reviewed.
|Journal Article Type||Article|
|Publication Date||Jun 23, 2015|
|Journal||International Journal of Genomics|
|Publisher||Hindawi Publishing Corporation|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Simpson, S., Edwards, J., Ferguson-Mignan, T. F., Cobb, M., Mongan, N. P., & Rutland, C. S. (2015). Genetics of human and canine dilated cardiomyopathy. International Journal of Genomics, 2015, https://doi.org/10.1155/2015/204823|
|Keywords||cardiovascular disease, dilated cardiomyopathy|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0|
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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