Genetics of human and canine dilated cardiomyopathy

Simpson, Siobhan; Edwards, Jennifer; Ferguson-Mignan, Thomas F.N.; Cobb, Malcolm; Mongan, Nigel P.; Rutland, Catrin S.

Abstract

Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than 50 genetic loci associated with the disease. Despite canine DCM having similar disease progression to human DCM studies into the genetic basis of canine DCM lag far behind those of human DCM. In this review the aetiology, epidemiology, and clinical characteristics of canine DCM are examined, along with highlighting possible different subtypes of canine DCM and their potential relevance to human DCM. Finally the current position of genetic research into canine and human DCM, including the genetic loci, is identified and the reasons many studies may have failed to find a genetic association with canine DCM are reviewed.

Citation

Simpson, S., Edwards, J., Ferguson-Mignan, T. F., Cobb, M., Mongan, N. P., & Rutland, C. S. (2015). Genetics of human and canine dilated cardiomyopathy. International Journal of Genomics, 2015, Article 204823. https://doi.org/10.1155/2015/204823

• Journal Article Type: Article
• Acceptance Date: Jun 23, 2015
• Publication Date: Jun 23, 2015
• Deposit Date: Oct 12, 2015
• Publicly Available Date: Oct 12, 2015
• Journal: International Journal of Genomics
• Print ISSN: 2314-436X
• Electronic ISSN: 2314-4378
• Publisher: Hindawi
• Peer Reviewed: Peer Reviewed
• Volume: 2015
• Article Number: 204823
• DOI: https://doi.org/10.1155/2015/204823
• Keywords: cardiovascular disease, dilated cardiomyopathy
• Public URL: https://nottingham-repository.worktribe.com/output/753878
• Publisher URL: http://www.hindawi.com/journals/ijg/2015/204823/
• Contract Date: Oct 12, 2015