S. J. White
Antigen array for serological diagnosis and novel allergen identification in severe equine asthma
White, S. J.; Moore-Colyer, M.; Marti, E.; Hannant, D.; Gerber, V.; Coüetil, L.; Richard, E. A.; Alcocer, M.
E. A. Richard
Severe equine asthma (sEA), which closely resembles human asthma, is a debilitating and performance-limiting allergic respiratory disorder which affects 14% of horses in the Northern Hemisphere and is associated with increased allergen-specific immunoglobulin E (IgE) against a range of environmental proteins. A comprehensive microarray platform was developed to enable the simultaneous detection of allergen-specific equine IgE in serum against a wide range of putative allergenic proteins. The microarray revealed a plethora of novel pollen, bacteria, mould and arthropod proteins significant in the aetiology of sEA. Moreover, the analyses revealed an association between sEA-affected horses and IgE antibodies specific for proteins derived from latex, which has traditionally been ubiquitous to the horse’s environment in the form of riding surfaces and race tracks. Further work is required to establish the involvement of latex proteins in sEA as a potential risk factor. This work demonstrates a novel and rapid approach to sEA diagnosis, providing a platform for tailored management and the development of allergen-specific immunotherapy.
|Journal Article Type||Article|
|Publisher||Nature Publishing Group|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||White, S. J., Moore-Colyer, M., Marti, E., Hannant, D., Gerber, V., Coüetil, L., …Alcocer, M. (2019). Antigen array for serological diagnosis and novel allergen identification in severe equine asthma. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-51820-7|
|Additional Information||Received: 24 April 2019; Accepted: 8 October 2019; First Online: 23 October 2019; : The authors declare no competing interests.|
Scientific Reports SEA Paper 23 Oct 2019