All Outputs (419)

A polygenic risk score for alcohol-related cirrhosis among heavy drinkers with European ancestry (2024)
Journal Article

Background & Aims: Polygenic Risk Scores (PRS) based on results from genome-wide association studies offer the prospect of risk stratification for many common and complex diseases. We developed a PRS for alcohol-related cirrhosis by comparing SNPs am... Read More about A polygenic risk score for alcohol-related cirrhosis among heavy drinkers with European ancestry.

Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: Human ex-vivo study (2024)
Journal Article

High dose glucocorticoids: Improving outcomes of emergency laparotomy by reducing inflammation (2024)
Journal Article

The characteristics and prognostic significance of histone H1 expression in breast cancer (2024)
Journal Article

Sparsely PEGylated poly(beta-amino ester) polyplexes enhance antigen specific T-cell response of a bivalent SARS-CoV-2 DNA vaccine (2024)
Journal Article

DNA technology has emerged as a promising route to accelerated manufacture of sequence agnostic vaccines. For activity, DNA vaccines must be protected and delivered to the correct antigen presenting cells. However, the physicochemical properties of t... Read More about Sparsely PEGylated poly(beta-amino ester) polyplexes enhance antigen specific T-cell response of a bivalent SARS-CoV-2 DNA vaccine.

Neuroinflammation and Lysosomal Abnormalities Characterise the Essential Role for Oxidation Resistance 1 in the Developing and Adult Cerebellum (2024)
Journal Article

Loss-of-function mutations in the TLDc family of proteins cause a range of severe childhood-onset neurological disorders with common clinical features that include cerebellar neurodegeneration, ataxia and epilepsy. Of these proteins, oxidation resist... Read More about Neuroinflammation and Lysosomal Abnormalities Characterise the Essential Role for Oxidation Resistance 1 in the Developing and Adult Cerebellum.

Protein Oxidative Modifications in Neurodegenerative Diseases: From Advances in Detection and Modelling to Their Use as Disease Biomarkers (2024)
Journal Article

Oxidation–reduction post-translational modifications (redox-PTMs) are chemical alterations to amino acids of proteins. Redox-PTMs participate in the regulation of protein conformation, localization and function, acting as signalling effectors that im... Read More about Protein Oxidative Modifications in Neurodegenerative Diseases: From Advances in Detection and Modelling to Their Use as Disease Biomarkers.

Population infection estimation from wastewater surveillance for SARS-CoV-2 in Nagpur, India during the second pandemic wave (2024)
Journal Article

Wastewater-based epidemiology (WBE) has emerged as an effective environmental surveillance tool for predicting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease outbreaks in high-income countries (HICs) with centralized sewage infr... Read More about Population infection estimation from wastewater surveillance for SARS-CoV-2 in Nagpur, India during the second pandemic wave.

How Long Does It Take to Read a Mammogram? Investigating the Reading Time of Digital Breast Tomosynthesis and Digital Mammography (2024)
Journal Article

Purpose To analyse digital breast tomosynthesis (DBT) reading times in the screening setting, compared to 2D full-field digital mammography (FFDM), and investigate the impact of reader experience and professional group on interpretation times. Me... Read More about How Long Does It Take to Read a Mammogram? Investigating the Reading Time of Digital Breast Tomosynthesis and Digital Mammography.

ATF4 as a Prognostic Marker and Modulator of Glutamine Metabolism in Estrogen Receptor Positive Breast Cancer (2024)
Journal Article

Introduction: ATF4, a stress-responsive transcription factor that upregulates adaptive genes, is a potential prognostic marker and modulator of glutamine metabolism in breast cancer. However, its exact role remains to be elucidated. Methods: ATF4... Read More about ATF4 as a Prognostic Marker and Modulator of Glutamine Metabolism in Estrogen Receptor Positive Breast Cancer.

A requirement for the use of supplementary oxygen to guide medical treatment decisions may introduce bias against non-white individuals (2024)
Journal Article

Immunohistochemical inflammation in histologically normal gallbladders containing gallstones (2024)
Journal Article

Background: The aim of this study was to establish features of inflammation in histologically normal gallbladders with gallstones and compare the expression of inflammatory markers in acutely and chronically inflamed gallbladders. Methods: Immunohist... Read More about Immunohistochemical inflammation in histologically normal gallbladders containing gallstones.

Tripartite Motif Containing 2, a glutamine metabolism-associated protein, predicts poor patient outcome in triple negative breast cancer treated with chemotherapy (2024)
Journal Article

Background Breast cancer (BC) remains heterogeneous in terms of prognosis and response to treatment. Metabolic reprogramming is a critical part of oncogenesis and a potential therapeutic target. Glutaminase (GLS), which generates glutamate from glu... Read More about Tripartite Motif Containing 2, a glutamine metabolism-associated protein, predicts poor patient outcome in triple negative breast cancer treated with chemotherapy.

Intraoperative spectroscopic evaluation of sentinel lymph nodes in breast cancer surgery (2024)
Journal Article

Background and objectives: Sentinel lymph node (SLN) biopsy is a standard procedure for patients with breast cancer and normal axilla on imaging. Positive SLNs on histological examination can lead to a subsequent surgery for axillary lymph node clear... Read More about Intraoperative spectroscopic evaluation of sentinel lymph nodes in breast cancer surgery.

Deciphering the Clinical Behaviour of Invasive Lobular Carcinoma of the Breast Defines an Aggressive Subtype (2024)
Journal Article

Background: Invasive lobular carcinoma (ILC), the most common special type of breast cancer (BC), has unique clinical behaviour and is different from invasive ductal carcinoma of no special type (IDC-NST). However, ILC further comprises a diverse gro... Read More about Deciphering the Clinical Behaviour of Invasive Lobular Carcinoma of the Breast Defines an Aggressive Subtype.

Pancreatic neuroendocrine tumours: a comparison of cytological classification systems. (2024)
Journal Article

Aims: Cytological classification systems provide a standardised interpretation framework for reporting cytological specimens. Three well-known classification systems can be applied when reporting pancreatic cytology. This study aimed to compare the a... Read More about Pancreatic neuroendocrine tumours: a comparison of cytological classification systems..

Enabling High-fidelity Personalized Pharmaceutical Tablets through Multimaterial Inkjet 3D Printing with a Water-soluble Excipient (2024)
Journal Article

Additive manufacturing offers manufacture of personalised pharmaceutical tablets through design freedoms and material deposition control at an individual voxel level. This control goes beyond geometry and materials choices: inkjet based 3D printing e... Read More about Enabling High-fidelity Personalized Pharmaceutical Tablets through Multimaterial Inkjet 3D Printing with a Water-soluble Excipient.

Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task (2024)
Journal Article

Fecal microbiota transplantation: current challenges and future landscapes (2024)
Journal Article

Given the importance of gut microbial homeostasis in maintaining health, there has been considerable interest in developing innovative therapeutic strategies for restoring gut microbiota. One such approach, fecal microbiota transplantation (FMT), is... Read More about Fecal microbiota transplantation: current challenges and future landscapes.

Multiple drug-delivery strategies to enhance the pharmacological and toxicological properties of Mefenamic acid (2024)
Journal Article

Objective: To improve the biological and toxicological properties of Mefenamic acid (MA), the galactosylated prodrug of MA named MefeGAL was included in polymeric solid dispersions (PSs) composed of poly(glycerol adipate) (PGA) and Pluronic® F68 (Mef... Read More about Multiple drug-delivery strategies to enhance the pharmacological and toxicological properties of Mefenamic acid.