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In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer’s Disease (2021)
Journal Article
Amat-Ur-rasool, H., Ahmed, M., Hasnain, S., Ahmed, A., & Carter, W. G. (2022). In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer’s Disease. Current Issues in Molecular Biology, 44(1), 152-175. https://doi.org/10.3390/cimb44010012

The number of patients with neurodegenerative diseases, particularly Alzheimer’s disease (AD), continues to grow yearly. Cholinesterase inhibitors (ChEIs) represent the first-line symptomatic drug treatment for mild-to-moderate AD; however, there is... Read More about In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer’s Disease.

The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies (2021)
Journal Article
Prakash, S., & Carter, W. G. (2021). The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies. Brain Sciences, 11(12), Article 1573. https://doi.org/10.3390/BRAINSCI11121573

Currently, there are no pharmacological treatments able to reverse nigral degeneration in Parkinson’s disease (PD), hence the unmet need for the provision of neuroprotective agents. Cannabis-derived phytocannabinoids (CDCs) and resveratrol (RSV) may... Read More about The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies.

Mental health among elite sportspeople: Lessons for medical education (2021)
Journal Article
Walker, I., Brierley, E., Patel, T., Jaffer, R., Rajpara, M., Heslop, C., & Patel, R. (2021). Mental health among elite sportspeople: Lessons for medical education. Medical Teacher, 44(2), 214-216. https://doi.org/10.1080/0142159X.2021.1994134

Leading sportspeople across 2021, such as Simone Biles (US gymnast), Naomi Osaka (Japanese tennis player) and Ben Stokes (English cricketer), have talked openly about the pressure of performing on the highest stage, including the challenge of managin... Read More about Mental health among elite sportspeople: Lessons for medical education.

Prevalence and Impact of Chronic Edema in Bariatric Patients: A LIMPRINT Study (2021)
Journal Article
Newman, A., Keeley, V., Pinnington, L., Green, C., Riches, K., Franks, P. J., …Moffatt, C. J. (2021). Prevalence and Impact of Chronic Edema in Bariatric Patients: A LIMPRINT Study. Lymphatic Research and Biology, 19(5), 431-441. https://doi.org/10.1089/lrb.2021.0055

Background: Chronic edema (CO) is a complex condition, arising from different factors, including immobility and obesity. Edema and obesity can have a significant impact on quality of life of patients and their families. Understanding how to manage ed... Read More about Prevalence and Impact of Chronic Edema in Bariatric Patients: A LIMPRINT Study.

Applying sport psychology in health professions education: A systematic review of performance mental skills training (2021)
Journal Article
Sandars, J., Jenkins, L., Church, H., Patel, R., Rumbold, J., Maden, M., …Brown, J. (2022). Applying sport psychology in health professions education: A systematic review of performance mental skills training. Medical Teacher, 44(1), 71-78. https://doi.org/10.1080/0142159X.2021.1966403

Introduction Health professionals are expected to consistently perform to a high standard during a variety of challenging clinical situations, which can provoke stress and impair their performance. There is increasing interest in applying sport psyc... Read More about Applying sport psychology in health professions education: A systematic review of performance mental skills training.

Harnessing the medical humanities to consider LGBT+ elder healthcare within the undergraduate curriculum (2021)
Presentation / Conference
Agius, S., & Church, H. (2021, August). Harnessing the medical humanities to consider LGBT+ elder healthcare within the undergraduate curriculum. Poster presented at AMEE 2021, Virtual

Background: Many older LGBT+ adults [elders] in the UK will have endured extraordinary discrimination and homophobia/transphobia during their life course, often intersectional, which may have had an enduring impact upon their physical and mental well... Read More about Harnessing the medical humanities to consider LGBT+ elder healthcare within the undergraduate curriculum.

Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild-type TNFR1 activity (2021)
Journal Article
Albogami, S., Todd, I., Negm, O., Fairclough, L. C., & Tighe, P. J. (2021). Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild-type TNFR1 activity. Immunology, https://doi.org/10.1111/imm.13400

The tumour necrosis factor receptor superfamily (TNFRSF) members contain cysteine-rich domains (CRD) in their extracellular regions, and the membrane-distal CRD1 forms homologous interactions in the absence of ligand. The CRD1 is therefore termed a p... Read More about Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild-type TNFR1 activity.

Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans (2021)
Journal Article
Willis, C. R., Gallagher, I. J., Wilkinson, D. J., Brook, M. S., Bass, J. J., Phillips, B. E., …Atherton, P. J. (2021). Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans. FASEB Journal, 35(9), Article e21830. https://doi.org/10.1096/fj.202100276RR

Muscle disuse leads to a rapid decline in muscle mass, with reduced muscle protein synthesis (MPS) considered the primary physiological mechanism. Here, we employed a systems biology approach to uncover molecular networks and key molecular candidates... Read More about Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans.

The FAST Workstation Shows Construct Validity and Participant Endorsement (2021)
Journal Article
Baxter, J. A., Bhamber, N. S., Patel, R. S., & Tennent, D. (2021). The FAST Workstation Shows Construct Validity and Participant Endorsement. Arthroscopy, Sports Medicine, and Rehabilitation, 3(4), e1133-e1140. https://doi.org/10.1016/j.asmr.2021.04.004

Purpose: To determine in what way the proposed simulation-based intervention (SBI) is an effective intervention for use in basic arthroscopic skills training. Methods: Twenty candidates were recruited and grouped according to experience. Performance... Read More about The FAST Workstation Shows Construct Validity and Participant Endorsement.

The F3 phenomenon: Early?career training breaks in medical training. A scoping review (2021)
Journal Article
Church, H. R., & Agius, S. (2021). The F3 phenomenon: Early?career training breaks in medical training. A scoping review. Medical Education, 55(9), 1033-1046. https://doi.org/10.1111/medu.14543

Background Since 2017 more than 50% of UK doctors have undertaken a ‘Foundation 3 (F3) Year’ training break after completing their Foundation Programme (the first two years following graduation), rather than immediately enter specialty training. The... Read More about The F3 phenomenon: Early?career training breaks in medical training. A scoping review.

The experience of widening participation students in undergraduate medical education in the UK: A qualitative systematic review (2021)
Journal Article
Krsti?, C., Krsti?, L., Tulloch, A., Agius, S., Warren, A., & Doody, G. A. (2021). The experience of widening participation students in undergraduate medical education in the UK: A qualitative systematic review. Medical Teacher, 43(9), 1044-1053. https://doi.org/10.1080/0142159x.2021.1908976

Most Widening Participation (WP) research is focused on medical school recruitment; there is a paucity of research examining whether the experience of medical school itself is an equal experience for both 'traditional' and WP students. This qualitati... Read More about The experience of widening participation students in undergraduate medical education in the UK: A qualitative systematic review.

The challenge of understanding, evaluating and providing feedback on regulation during group learning (2021)
Journal Article
Sandars, J., Cecilio-Fernandes, D., Gandomkar, R., & Patel, R. (2021). The challenge of understanding, evaluating and providing feedback on regulation during group learning. Scientia Medica, 31(1), Article e39294. https://doi.org/10.15448/1980-6108.2021.1.39294

Learning in groups is commonly used in academic and clinical health professions education (HPE). There is growing recognition that regulation during learning is essential for both the individual learner and group learning. The authors in this article... Read More about The challenge of understanding, evaluating and providing feedback on regulation during group learning.

Rethinking the course of psychotic disorders: modelling long-term symptom trajectories (2021)
Journal Article
Morgan, C., Dazzan, P., Lappin, J., Heslin, M., Donoghue, K., Fearon, P., …Reininghaus, U. (2021). Rethinking the course of psychotic disorders: modelling long-term symptom trajectories. Psychological Medicine, https://doi.org/10.1017/S0033291720004705

Background The clinical course of psychotic disorders is highly variable. Typically, researchers have captured different course types using broad pre-defined categories. However, whether these adequately capture symptom trajectories of psychotic di... Read More about Rethinking the course of psychotic disorders: modelling long-term symptom trajectories.