Prevalence and Impact of Chronic Edema in Bariatric Patients: A LIMPRINT Study

Newman, Amy; Keeley, Vaughan; Pinnington, Lorraine; Green, Carol; Riches, Katie; Franks, Peter J.; Idris, Iskandar; Moffatt, Christine J.

Abstract

Background: Chronic edema (CO) is a complex condition, arising from different factors, including immobility and obesity. Edema and obesity can have a significant impact on quality of life of patients and their families. Understanding how to manage edema in obese patients is an increasing challenge for both patients and clinicians. As effective treatment options are limited for this population, it is more cost-effective for patients to lose weight before starting treatment. When patients cannot maintain weight loss, one option is to have bariatric surgery. This study was part of LIMPRINT: Lymphedema IMpact and PRevalence INTernational, a study with the aim of identifying the prevalence and impact of CO in different countries and health care settings. Study Purpose: To evaluate the prevalence and impact of CO among patients in a United Kingdom bariatric surgical service. Methods and Results: The gold standard pitting test assessed the presence of edema. General (EuroQOL-5 Dimensions [EQ-5D], RAND 36-Item Short Form Health Survey, Version 1.0 [SF-36], Generalized Anxiety Disorder 7-Item Scale [GAD-7] and Patient Health Questionnaire-9 [PHQ-9]), and edema-specific (Lymphedema Quality of Life [LYMQOL]) quality-of-life questionnaires were used to evaluate impact of edema. The prevalence of edema was 52.1% (25 of 48 participants had edema), potentially linked to obesity, immobility, and medications. Most participants had International Society of Lymphology (ISL) Stage I edema. There were no statistically significant differences between the quality of life of participants with and without edema. However, comparing SF-36 results and normative population data indicated that quality of life was much lower than those in the normative population. Conclusions: This study highlights the high prevalence of edema and low quality of life of this bariatric population. ClinicalTrials.gov ID: NCT03154593.

Citation

Newman, A., Keeley, V., Pinnington, L., Green, C., Riches, K., Franks, P. J., …Moffatt, C. J. (2021). Prevalence and Impact of Chronic Edema in Bariatric Patients: A LIMPRINT Study. Lymphatic Research and Biology, 19(5), 431-441. https://doi.org/10.1089/lrb.2021.0055

• Journal Article Type: Article
• Acceptance Date: Sep 15, 2021
• Online Publication Date: Oct 15, 2021
• Publication Date: Oct 1, 2021
• Deposit Date: Dec 2, 2021
• Publicly Available Date: Dec 2, 2021
• Journal: Lymphatic Research and Biology
• Print ISSN: 1539-6851
• Electronic ISSN: 1557-8585
• Publisher: Mary Ann Liebert Inc
• Peer Reviewed: Peer Reviewed
• Volume: 19
• Issue: 5
• Pages: 431-441
• DOI: https://doi.org/10.1089/lrb.2021.0055
• Keywords: Cardiology and Cardiovascular Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/6846535
• Publisher URL: https://www.liebertpub.com/doi/10.1089/lrb.2021.0055
• Additional Information: Estimated acceptance date.