All Outputs (131)

Oncoplastic breast surgery in older women with primary breast cancer: a systematic review (2023)
Journal Article

Oncoplastic procedures allow excision of larger breast tumours, or unfavourable tumour/breast ratio lesions while achieving a good cosmetic outcome. This increases the pool of patients eligible for breast conservation over mastectomy, reducing the ne... Read More about Oncoplastic breast surgery in older women with primary breast cancer: a systematic review.

Comparison of the effectiveness of exclusively facilitated clinical teaching as an alternative to traditional practice-based primary care placements (2023)
Journal Article

Introduction: COVID-19 presented major challenges to undergraduate GP placement capacity and there was an increased reliance on clinical training using facilitated simulation. The authors present a novel comparison of the effectiveness and cost-effec... Read More about Comparison of the effectiveness of exclusively facilitated clinical teaching as an alternative to traditional practice-based primary care placements.

The Use of Art Observation Interventions to Improve Medical Students' Diagnostic Skills: A Scoping Review (2023)
Journal Article

Clinical observation skills are fundamental to the practice of medicine. Yet, the skill of looking carefully is rarely taught within the medical curriculum. This may be a contributory factor in diagnostic errors in healthcare. A growing number of med... Read More about The Use of Art Observation Interventions to Improve Medical Students' Diagnostic Skills: A Scoping Review.

Predictors of the quality of work life and job satisfaction among serving military healthcare personnel in the Nigerian armed forces (2023)
Journal Article

Introduction: Quality of work life and perception affects the productivity of healthcare professionals. The study aimed to determine the quality of work life (QWL) and job satisfaction (JS) of military healthcare professionals in Nigeria. Methods: A... Read More about Predictors of the quality of work life and job satisfaction among serving military healthcare personnel in the Nigerian armed forces.

Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival (2023)
Journal Article

Introduction Breast cancer in older women tends to have more favourable biology, compared to younger women. Androgen receptor (AR) is significant for breast tumour carcinogenesis; however, the role of AR in older women has not been fully explored.... Read More about Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival.

Differentiated Neurons Are More Vulnerable to Organophosphate and Carbamate Neurotoxicity than Undifferentiated Neurons Due to the Induction of Redox Stress and Accumulate Oxidatively-Damaged Proteins (2023)
Journal Article

Organophosphate (OP) and carbamate pesticides are toxic to pests through targeted inhibition of acetylcholinesterase (AChE). However, OPs and carbamates may be harmful to non-target species including humans and could induce developmental neurotoxicit... Read More about Differentiated Neurons Are More Vulnerable to Organophosphate and Carbamate Neurotoxicity than Undifferentiated Neurons Due to the Induction of Redox Stress and Accumulate Oxidatively-Damaged Proteins.

Acai Berry (Euterpe sp.) Extracts Are Neuroprotective against L-Glutamate-Induced Toxicity by Limiting Mitochondrial Dysfunction and Cellular Redox Stress (2023)
Journal Article

Aberrant accumulation of the neurotransmitter L-glutamate (L-Glu) has been implicated as a mechanism of neurodegeneration, and the release of L-Glu after stroke onset leads to a toxicity cascade that results in neuronal death. The acai berry (Euterpe... Read More about Acai Berry (Euterpe sp.) Extracts Are Neuroprotective against L-Glutamate-Induced Toxicity by Limiting Mitochondrial Dysfunction and Cellular Redox Stress.

The roles and experiences of informal carers providing care to people with advanced cancer in Africa—A systematic review and critical interpretive analysis (2023)
Journal Article

There is an increasing prevalence of cancer in Africa with approximately 80% of cancers diagnosed at an advanced stage. High out-of-pocket healthcare costs and overstretched health systems lead to heavy reliance on informal carers for cancer care. Th... Read More about The roles and experiences of informal carers providing care to people with advanced cancer in Africa—A systematic review and critical interpretive analysis.

Really good stuff—May 2023 editorial (2023)
Journal Article

Under- and post-graduate training to manage the acutely unwell patient: a scoping review (2023)
Journal Article

Background: Junior doctors are often the first responders to acutely unwell patients and yet frequently report feeling under-prepared to do so. To understand whether this is consequential of how medical students and doctors are trained to manage acut... Read More about Under- and post-graduate training to manage the acutely unwell patient: a scoping review.

A qualitative study of patients’ and carers’ perspectives on factors influencing access to hypertension care and compliance with treatment in Nigeria (2023)
Journal Article

Objective: We explored patients’ and carers’ perspectives on factors influencing access to hypertension care and compliance with treatment. Methods: This was a qualitative study using in-depth interviews with hypertensive patients and/or famil... Read More about A qualitative study of patients’ and carers’ perspectives on factors influencing access to hypertension care and compliance with treatment in Nigeria.

The educational value of situational judgement tests (SJTs) when used during undergraduate medical training: A systematic review and narrative synthesis (2023)
Journal Article

Introduction Situational judgement tests (SJTs) are a recognised assessment method for admission into medical school, selection into postgraduate training programs, and postgraduate competency assessment. More recently, however, SJTs have been used... Read More about The educational value of situational judgement tests (SJTs) when used during undergraduate medical training: A systematic review and narrative synthesis.

A non-randomised controlled study to assess the effectiveness of a new proactive multidisciplinary care intervention for older people living with frailty (2023)
Journal Article

Background Integrated care may improve outcomes for older people living with frailty. We aimed to assess the effectiveness of a new, anticipatory, multidisciplinary care service in improving the wellbeing and quality of life (QoL) of older people li... Read More about A non-randomised controlled study to assess the effectiveness of a new proactive multidisciplinary care intervention for older people living with frailty.

Mefloquine loaded niosomes as a promising approach for the treatment of acute and chronic toxoplasmosis (2022)
Journal Article

Toxoplasmosis is a disease with a worldwide distribution and significant morbidity and mortality. In search of effective treatment, mefloquine (MQ) was repurposed and loaded with niosomes to treat acute and chronic phases of toxoplasmosis in experime... Read More about Mefloquine loaded niosomes as a promising approach for the treatment of acute and chronic toxoplasmosis.

The Potential of Stilbene Compounds to Inhibit Mpro Protease as a Natural Treatment Strategy for Coronavirus Disease-2019 (2022)
Journal Article

COVID-19 disease has had a global impact on human health with increased levels of morbidity and mortality. There is an unmet need to design and produce effective antivirals to treat COVID-19. This study aimed to explore the potential ability of natur... Read More about The Potential of Stilbene Compounds to Inhibit Mpro Protease as a Natural Treatment Strategy for Coronavirus Disease-2019.

Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men (2022)
Journal Article

Introduction Ageing skeletal muscles become both insulin resistant and atrophic. The hormone glucagon-like peptide 1 (GLP-1) facilitates postprandial glucose uptake as well as augmenting muscle perfusion, independent of insulin action. We thus hypot... Read More about Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men.

Usability: An introduction to and literature review of usability testing for educational resources in radiation oncology (2022)
Journal Article

Usability, or the ease with which something can be used, is a key aspect in ensuring end-users can achieve the best possible outcomes from a given educational resource. Ideally usability testing should take place iteratively throughout the design of... Read More about Usability: An introduction to and literature review of usability testing for educational resources in radiation oncology.

Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium (2022)
Journal Article

Our aim was to, firstly, identify characteristics at first-episode of psychosis that are associated with later antipsychotic treatment resistance (TR) and, secondly, to develop a parsimonious prediction model for TR. We combined data from ten prospec... Read More about Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium.

Motor unit dysregulation following 15 days of unilateral lower limb immobilisation (2022)
Journal Article

Abstract: Disuse atrophy, caused by situations of unloading such as limb immobilisation, causes a rapid yet diverging reduction in skeletal muscle function when compared to muscle mass. While mechanistic insight into the loss of mass is well studied,... Read More about Motor unit dysregulation following 15 days of unilateral lower limb immobilisation.

Factors associated with the timely completion of doctoral research studies in clinical pharmacy: A mixed-methods study (2022)
Journal Article

Introduction There is growing scientific evidence of mental and well-being issues that doctoral research students face as a result of not finishing their program on time. This study aims to explore the factors associated with the timely completion o... Read More about Factors associated with the timely completion of doctoral research studies in clinical pharmacy: A mixed-methods study.