Skip to main content

Research Repository

Advanced Search

All Outputs (559)

Multicentre cluster randomised trial comparing a community group exercise programme with home based exercise with usual care for people aged 65 and over in primary care (2014)
Journal Article
Iliffe, S., Kendrick, D., Morris, R., Masud, T., Gage, H., Skelton, D., …Belcher, C. (2014). Multicentre cluster randomised trial comparing a community group exercise programme with home based exercise with usual care for people aged 65 and over in primary care. Health Technology Assessment, 18(49), https://doi.org/10.3310/hta18490

Background: Regular physical activity (PA) reduces the risk of falls and hip fractures, and mortality from all causes. However, PA levels are low in the older population and previous intervention studies have demonstrated only modest, short-term impr... Read More about Multicentre cluster randomised trial comparing a community group exercise programme with home based exercise with usual care for people aged 65 and over in primary care.

The SNAP trial: A randomised placebo-controlled trial of nicotine replacement therapy in pregnancy - Clinical effectiveness and safety until 2 years after delivery, with economic evaluation (2014)
Journal Article
Cooper, S., Lewis, S., Thornton, J., Marlow, N., Watts, K., Britton, J., …Coleman, T. (2014). The SNAP trial: A randomised placebo-controlled trial of nicotine replacement therapy in pregnancy - Clinical effectiveness and safety until 2 years after delivery, with economic evaluation. Health Technology Assessment, 18(54), 1-128. https://doi.org/10.3310/hta18540

Background: Smoking during pregnancy causes many adverse pregnancy and birth outcomes. Nicotine replacement therapy (NRT) is effective for cessation outside pregnancy but efficacy and safety in pregnancy are unknown. We hypothesised that NRT would in... Read More about The SNAP trial: A randomised placebo-controlled trial of nicotine replacement therapy in pregnancy - Clinical effectiveness and safety until 2 years after delivery, with economic evaluation.

The Optimal Study: describing the key components of optimal health care delivery to UK care home residents: a research protocol (2014)
Journal Article
Gordon, A. L., Goodman, C., Dening, T., Davies, S., Gladman, J. R., Bell, B. G., …Victor, C. (2014). The Optimal Study: describing the key components of optimal health care delivery to UK care home residents: a research protocol. Journal of the American Medical Directors Association, 15(9), https://doi.org/10.1016/j.jamda.2014.06.011

Long term institutional care in the UK is provided by care homes. Residents have prevalent cognitive impairment and disability, have multiple diagnoses and are subject to polypharmacy. Prevailing models of healthcare provision - ad hoc, reactive and... Read More about The Optimal Study: describing the key components of optimal health care delivery to UK care home residents: a research protocol.

Predicting risk of upper gastrointestinal bleed and intracranial bleed with anticoagulants: cohort study to derive and validate the QBleed scores (2014)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2014). Predicting risk of upper gastrointestinal bleed and intracranial bleed with anticoagulants: cohort study to derive and validate the QBleed scores. BMJ, 349, Article g4606. https://doi.org/10.1136/bmj.g4606

Objective: To develop and validate risk algorithms (QBleed) for estimating the absolute risk of upper gastrointestinal and intracranial bleed for patients with and without anticoagulation aged 21-99 years in primary care. Design: Open cohort study... Read More about Predicting risk of upper gastrointestinal bleed and intracranial bleed with anticoagulants: cohort study to derive and validate the QBleed scores.

Nicotine patch preloading for smoking cessation (the preloading trial): study protocol for a randomized controlled trial (2014)
Journal Article
Lindson-Hawley, N., Coleman, T., Docherty, G., Hajek, P., Lewis, S., Lycett, D., …Aveyard, P. (2014). Nicotine patch preloading for smoking cessation (the preloading trial): study protocol for a randomized controlled trial. Trials, 15(296), https://doi.org/10.1186/1745-6215-15-296

Background: The use of nicotine replacement therapy before quitting smoking is called nicotine preloading. Standard smoking cessation protocols suggest commencing nicotine replacement therapy only on the first day of quitting smoking (quit day) aimin... Read More about Nicotine patch preloading for smoking cessation (the preloading trial): study protocol for a randomized controlled trial.

Exploring safety systems for dispensing in community pharmacies: Focusing on how staff relate to organizational components (2014)
Journal Article
Harvey, J., Avery, A. J., Ashcroft, D., Boyd, M., Phipps, D. L., & Barber, N. (2015). Exploring safety systems for dispensing in community pharmacies: Focusing on how staff relate to organizational components. Research in Social and Administrative Pharmacy, 11(2), 216-227. https://doi.org/10.1016/j.sapharm.2014.06.005

Background: Identifying risk is an important facet of a safety practice in an organization. To identify risk, all components within a system of operation should be considered. In clinical safety practice, a team of people, technologies, procedures an... Read More about Exploring safety systems for dispensing in community pharmacies: Focusing on how staff relate to organizational components.

Coverage of common cancer types in UK national newspapers: A content analysis (2014)
Journal Article
Konfortion, J., Jack, R. H., & Davies, E. A. (2014). Coverage of common cancer types in UK national newspapers: A content analysis. BMJ Open, 4(7), https://doi.org/10.1136/bmjopen-2013-004677

Objective: To determine whether recent newspaper coverage of the four most common cancer types relates to their relative burden and national awareness months, and to identify the subject focus during highcoverage periods. Design: Content analysis usi... Read More about Coverage of common cancer types in UK national newspapers: A content analysis.

Parents' responses to receiving sickle cell or cystic fibrosis carrier results for their child following newborn screening (2014)
Journal Article
Qureshi, N., Ulph, F., Cullinan, T., & Kai, J. (2015). Parents' responses to receiving sickle cell or cystic fibrosis carrier results for their child following newborn screening. European Journal of Human Genetics, 23(4), 459–465. https://doi.org/10.1038/ejhg.2014.126

Universal newborn screening for sickle cell disorders and cystic fibrosis aims to enable the early identification and treatment of affected babies. Screening can also identify infants who are healthy carriers, with carrier results being the commonest... Read More about Parents' responses to receiving sickle cell or cystic fibrosis carrier results for their child following newborn screening.

Comparison of cotinine levels in pregnant women while smoking and when using nicotine replacement therapy (2014)
Journal Article
Bowker, K. A., Lewis, S., Coleman, T., Vaz, L. R., & Cooper, S. (2014). Comparison of cotinine levels in pregnant women while smoking and when using nicotine replacement therapy. Nicotine and Tobacco Research, 16(6), https://doi.org/10.1093/ntr/ntu029

BACKGROUND: Nicotine replacement therapy (NRT) helps smokers quit smoking, but trials indicate that there is no evidence that it is effective during pregnancy. As metabolism increases during pregnancy, NRT may deliver insufficient nicotine to allevia... Read More about Comparison of cotinine levels in pregnant women while smoking and when using nicotine replacement therapy.

Cost-effectiveness of interventions for increasing the possession of functioning smoke alarms in households with pre-school children: a modelling study (2014)
Journal Article
Saramago, P., Cooper, N. J., Sutton, A. J., Hayes, M., Dunn, K., Manca, A., & Kendrick, D. (2014). Cost-effectiveness of interventions for increasing the possession of functioning smoke alarms in households with pre-school children: a modelling study. BMC Public Health, 14, Article 459. https://doi.org/10.1186/1471-2458-14-459

Background The UK has one of the highest rates for deaths from fire and flames in children aged 0-14 years compared to other high income countries. Evidence shows that smoke alarms can reduce the risk of fire-related injury but little exists on th... Read More about Cost-effectiveness of interventions for increasing the possession of functioning smoke alarms in households with pre-school children: a modelling study.

Longitudinal cohort survey of women's smoking behaviour and attitudes in pregnancy: study methods and baseline data (2014)
Journal Article
Orton, S., Bowker, K., Cooper, S., Naughton, F., Ussher, M., Pickett, K. E., …Coleman, T. (2014). Longitudinal cohort survey of women's smoking behaviour and attitudes in pregnancy: study methods and baseline data. BMJ Open, 4(5), https://doi.org/10.1136/bmjopen-2014-004915

Objectives: To report methods used to assemble a contemporary pregnancy cohort for investigating influences on smoking behaviour before, during and after pregnancy and to report characteristics of women recruited. Design: Longitudinal cohort surve... Read More about Longitudinal cohort survey of women's smoking behaviour and attitudes in pregnancy: study methods and baseline data.

Injury among children and young adults with epilepsy (2014)
Journal Article
Prasad, V., Kendrick, D., Sayal, K., Thomas, S. L., & West, J. (in press). Injury among children and young adults with epilepsy. Pediatrics, 133(5), https://doi.org/10.1542/peds.2013-2554

OBJECTIVE: To investigate whether children and young adults with epilepsy are at a greater risk of fracture, thermal injury, or poisoning than those without. METHODS: A cohort study was conducted by using the Clinical Practice Research Datalink (198... Read More about Injury among children and young adults with epilepsy.

Introducing genetic testing for cardiovascular disease in primary care: a qualitative study (2014)
Journal Article
Middlemass, J., Yazdani, M., Kai, J., Standen, P., & Qureshi, N. (2014). Introducing genetic testing for cardiovascular disease in primary care: a qualitative study. British Journal of General Practice, 64(622), Article e282-e289. https://doi.org/10.3399/bjgp14X679714

Background: While primary care systematically offers conventional cardiovascular risk assessment, genetic tests for coronary heart disease (CHD) are increasingly commercially available to patients. It is unclear how individuals may respond to these n... Read More about Introducing genetic testing for cardiovascular disease in primary care: a qualitative study.

The effect of the electronic transmission of prescriptions on dispensing errors and prescription enhancements made in English community pharmacies: a naturalistic stepped wedge study (2014)
Journal Article
Franklin, B. D., Reynolds, M., Sadler, S., Hibberd, R., Avery, A. J., Armstrong, S. J., …Barber, N. (2014). The effect of the electronic transmission of prescriptions on dispensing errors and prescription enhancements made in English community pharmacies: a naturalistic stepped wedge study. BMJ Quality and Safety, 23(8), https://doi.org/10.1136/bmjqs-2013-002776

Objectives: To compare prevalence and types of dispensing errors and pharmacists’ labelling enhancements, for prescriptions transmitted electronically versus paper prescriptions. Design: Naturalistic stepped wedge study. Setting: 15 English communi... Read More about The effect of the electronic transmission of prescriptions on dispensing errors and prescription enhancements made in English community pharmacies: a naturalistic stepped wedge study.

Nicotine dependence and biochemical exposure measures in the second trimester of pregnancy (2014)
Journal Article
Kwok, T. C., Taggar, J., Cooper, S., Lewis, S., & Coleman, T. (2014). Nicotine dependence and biochemical exposure measures in the second trimester of pregnancy. Nicotine and Tobacco Research, 16(2), https://doi.org/10.1093/ntr/ntt127

Introduction: The Heaviness of Smoking Index (HSI) is validated to measure nicotine dependence in nonpregnant smokers, and in these smokers, mean salivary and serum cotinine levels are related by a ratio of 1.25. However, as nicotine metabolism inc... Read More about Nicotine dependence and biochemical exposure measures in the second trimester of pregnancy.

Exploring recruitment barriers and facilitators in early cancer detection trials: the use of pre-trial focus groups (2014)
Journal Article
das Nair, R., Skellington Orr, K., Vedhara, K., & Kendrick, D. (2014). Exploring recruitment barriers and facilitators in early cancer detection trials: the use of pre-trial focus groups. Trials, 15(1), Article 98. https://doi.org/10.1186/1745-6215-15-98

Background Recruiting to randomized controlled trials is fraught with challenges; with less than one third recruiting to their original target. In preparation for a trial evaluating the effectiveness of a blood test to screen for lung cancer (the... Read More about Exploring recruitment barriers and facilitators in early cancer detection trials: the use of pre-trial focus groups.

Cost Effectiveness of a Pharmacist-Led Information Technology Intervention for Reducing Rates of Clinically Important Errors in Medicines Management in General Practices (PINCER) (2014)
Journal Article
Elliott, R., Putman, K. D., Franklin, M., Annemans, L., Verhaeghe, N., Eden, M., …Avery, A. J. (2014). Cost Effectiveness of a Pharmacist-Led Information Technology Intervention for Reducing Rates of Clinically Important Errors in Medicines Management in General Practices (PINCER). PharmacoEconomics, 32(6), 573-590. https://doi.org/10.1007/s40273-014-0148-8