Skip to main content

Research Repository

Advanced Search

Injury among children and young adults with epilepsy

Prasad, Vibhore; Kendrick, Denise; Sayal, Kapil; Thomas, Sara L.; West, Joe

Authors

Vibhore Prasad

DENISE KENDRICK denise.kendrick@nottingham.ac.uk
Professor of Primary Care Research

KAPIL SAYAL kapil.sayal@nottingham.ac.uk
Professor of Child and Adolescentpsychiatry

Sara L. Thomas

JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
Professor of Epidemiology



Abstract

OBJECTIVE: To investigate whether children and young adults with epilepsy are at a greater risk of fracture, thermal injury, or poisoning than those without.
METHODS: A cohort study was conducted by using the Clinical Practice Research Datalink (1987–2009), a longitudinal database containing primary care records. A total of 11 934 people with epilepsy and 46 598 without, aged between 1 and 24 years at diagnosis, were followed for a median (interquartile range) of 2.6 (0.8–5.9) years. The risk of fractures (including long bone fractures), thermal injuries, and poisonings (including medicinal and nonmedicinal poisonings) was estimated.
RESULTS: Adjusting for age, gender, Strategic Health Authority region, deprivation, and calendar year at study entry (and, for medicinal poisonings, behavior disorder), people with epilepsy had an 18% increase in risk of fracture (hazard ratio [HR] = 1.18; 95% confidence interval [CI], 1.09–1.27), a 23% increase in risk of long bone fracture (HR = 1.23; 95% CI, 1.10–1.38), a 49% increase in risk of thermal injury (HR = 1.49; 95% CI, 1.27–1.75), and more than twice the risk of poisoning (HR = 2.47; 95% CI, 2.15–2.84), which was limited to poisoning from medicinal products (medicinal HR = 2.54; 95% CI, 2.16–2.99; nonmedicinal HR = 0.96; 95% CI, 0.61–1.52).
CONCLUSIONS: Children and young adults with epilepsy are at a greater risk of fracture, thermal injury, and poisoning than those without. The greatest risk is from medicinal poisonings. Doctors and other health care professionals should provide injury and poison prevention advice at diagnosis and epilepsy reviews.

Citation

Prasad, V., Kendrick, D., Sayal, K., Thomas, S. L., & West, J. (in press). Injury among children and young adults with epilepsy. Pediatrics, 133(5), https://doi.org/10.1542/peds.2013-2554

Journal Article Type Article
Acceptance Date Jan 24, 2014
Online Publication Date May 1, 2014
Deposit Date Aug 31, 2017
Publicly Available Date Aug 31, 2017
Journal Pediatrics
Print ISSN 0031-4005
Electronic ISSN 0031-4005
Publisher American Academy of Pediatrics
Peer Reviewed Peer Reviewed
Volume 133
Issue 5
DOI https://doi.org/10.1542/peds.2013-2554
Keywords epilepsy, injury, fractures, burns, poisoning
Public URL http://eprints.nottingham.ac.uk/id/eprint/45284
Publisher URL http://pediatrics.aappublications.org/content/133/5/827
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

Files

Prasad Pediatrics 2014 AAM.pdf (552 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





You might also like



Downloadable Citations