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All Outputs (532)

An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England (2021)
Journal Article
Nafilyan, V., Humberstone, B., Mehta, N., Diamond, I., Coupland, C., Lorenzi, L., …Hippisley-Cox, J. (2021). An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England. The Lancet. Digital Health, 3(7), E425-E433. https://doi.org/10.1016/S2589-7500%2821%2900080-7

Background: Public policy measures and clinical risk assessments relevant to COVID-19 need to be aided by risk prediction models that are rigorously developed and validated. We aimed to externally validate a risk prediction algorithm (QCovid) to esti... Read More about An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England.

Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study (2021)
Journal Article
Patone, M., Thomas, K., Hatch, R., Tan, P. S., Coupland, C., Liao, W., …Hippisley-Cox, J. (2021). Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study. Lancet Infectious Diseases, 21(11), 1518-1528. https://doi.org/10.1016/s1473-3099%2821%2900318-2

Background: A more transmissible variant of SARS-CoV-2, the variant of concern 202012/01 or lineage B.1.1.7, has emerged in the UK. We aimed to estimate the risk of critical care admission, mortality in patients who are critically ill, and overall mo... Read More about Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study.

Impact of the national home safety equipment scheme ‘Safe At Home’ on hospital admissions for unintentional injury in children under 5: controlled interrupted time series analysis (2021)
Journal Article
Hill, T., Coupland, C., Kendrick, D., Jones, M., Akbari, A., Rodgers, S., …Orton, E. (2022). Impact of the national home safety equipment scheme ‘Safe At Home’ on hospital admissions for unintentional injury in children under 5: controlled interrupted time series analysis. Journal of Epidemiology and Community Health, 76(1), 53-59. https://doi.org/10.1136/jech-2021-216613

Background: Unintentional home injuries are a leading cause of preventable death in young children. Safety education and equipment provision improve home safety practices, but their impact on injuries is less clear. Between 2009 and 2011 a national h... Read More about Impact of the national home safety equipment scheme ‘Safe At Home’ on hospital admissions for unintentional injury in children under 5: controlled interrupted time series analysis.

Association Between Race and COVID-19 Outcomes Among 2.6 Million Children in England (2021)
Journal Article
Saatci, D., Ranger, T. A., Garriga, C., Clift, A. K., Zaccardi, F., Tan, P. S., …Hippisley-Cox, J. (2021). Association Between Race and COVID-19 Outcomes Among 2.6 Million Children in England. JAMA Pediatrics, 175(9), 928-938. https://doi.org/10.1001/jamapediatrics.2021.1685

Importance: Although children mainly experience mild COVID-19 disease, hospitalization rates are increasing, with limited understanding of underlying factors. There is an established association between race and severe COVID-19 outcomes in adults in... Read More about Association Between Race and COVID-19 Outcomes Among 2.6 Million Children in England.

Anticholinergic drugs and risk of dementia: Time for action? (2021)
Journal Article
Bell, B., Avery, A., Bishara, D., Coupland, C., Ashcroft, D., & Orrell, M. (2021). Anticholinergic drugs and risk of dementia: Time for action?. Pharmacology Research and Perspectives, 9(3), Article e00793. https://doi.org/10.1002/prp2.793

Evidence suggests that the prescription of bladder anticholinergics is increasing. Recent studies have accentuated concerns about whether certain prescribed medications could increase risk of dementia, including anticholinergic drugs, and specificall... Read More about Anticholinergic drugs and risk of dementia: Time for action?.

Regional lymphadenopathy following COVID-19 vaccination: considerations for primary care management (2021)
Journal Article
Garreffa, E., York, J., Turnbull, A., & Kendrick, D. (2021). Regional lymphadenopathy following COVID-19 vaccination: considerations for primary care management. British Journal of General Practice, 71(707), 284-285. https://doi.org/10.3399/bjgp21X716117

Regional lymphadenopathy has been rarely reported following the administration of vaccinations for tuberculosis, influenza, and human papillomavirus (≤1–2/100 000 vaccines).1,2 In the first months of 2021, there seems to have been an increase in the... Read More about Regional lymphadenopathy following COVID-19 vaccination: considerations for primary care management.

Subjective vision and hearing impairment and falls among community-dwelling adults: a prospective study in the Survey of Health, Ageing and Retirement in Europe (SHARE) (2021)
Journal Article
Ogliari, G., Ryg, J., Qureshi, N., Andersen-Ranberg, K., Scheel-Hincke, L. L., & Masud, T. (2021). Subjective vision and hearing impairment and falls among community-dwelling adults: a prospective study in the Survey of Health, Ageing and Retirement in Europe (SHARE). European Geriatric Medicine, 12(5), 1031-1043. https://doi.org/10.1007/s41999-021-00505-4

Purpose: To investigate the association between vision and hearing impairment and falls in community-dwelling adults aged ≥ 50 years. Methods: This is a prospective study on 50,986 participants assessed in Waves 6 and 7 of the Survey of Health, Agein... Read More about Subjective vision and hearing impairment and falls among community-dwelling adults: a prospective study in the Survey of Health, Ageing and Retirement in Europe (SHARE).

Keeping adults physically active after falls management exercise (FaME) programmes end: Development of a physical activity maintenance intervention (2021)
Journal Article
Sarah, A., Kendrick, D., Logan, P., & Orton, E. (2021). Keeping adults physically active after falls management exercise (FaME) programmes end: Development of a physical activity maintenance intervention. Pilot and Feasibility Studies, 7, Article 108. https://doi.org/10.1186/s40814-021-00844-w

Background: Falls prevention exercise programmes help to improve muscle strength, balance, physical function and reduce falling rates in older adults. Improvements in muscle strength, balance and physical function are reversed if older adults do not... Read More about Keeping adults physically active after falls management exercise (FaME) programmes end: Development of a physical activity maintenance intervention.

Depression, anxiety and stress during the COVID-19 pandemic: results from a New Zealand cohort study on mental well-being (2021)
Journal Article
Gasteiger, N., Vedhara, K., Massey, A., Jia, R., Ayling, K., Chalder, T., …Broadbent, E. (2021). Depression, anxiety and stress during the COVID-19 pandemic: results from a New Zealand cohort study on mental well-being. BMJ Open, 11(5), Article e045325. https://doi.org/10.1136/bmjopen-2020-045325

Objectives: The COVID-19 pandemic has caused unprecedented disruption to daily life. This study investigated depression, anxiety and stress in New Zealand (NZ) during the first ten weeks of the COVID-19 pandemic, and associated psychological and beha... Read More about Depression, anxiety and stress during the COVID-19 pandemic: results from a New Zealand cohort study on mental well-being.

The implementation, use and sustainability of a clinical decision support system for medication optimisation in primary care: A qualitative evaluation (2021)
Journal Article
Jeffries, M., Salema, N., Laing, L., Shamsuddin, A., Sheikh, A., Avery, A., …Keers, R. (2021). The implementation, use and sustainability of a clinical decision support system for medication optimisation in primary care: A qualitative evaluation. PLoS ONE, 16(5), Article e0250946. https://doi.org/10.1371/journal.pone.0250946

Background: The quality and safety of prescribing in general practice is important, Clinical decision support (CDS) systems can be used which present alerts to health professionals when prescribing in order to identify patients at risk of potentiall... Read More about The implementation, use and sustainability of a clinical decision support system for medication optimisation in primary care: A qualitative evaluation.

Predicting the risk of prostate cancer in asymptomatic men: a cohort study to develop and validate a novel algorithm (2021)
Journal Article
Coupland, C., & Hippisley-Cox, J. (2021). Predicting the risk of prostate cancer in asymptomatic men: a cohort study to develop and validate a novel algorithm. British Journal of General Practice, 71(706), e364-e371. https://doi.org/10.3399/bjgp20x714137

Background: Diagnosis of prostate cancer at an early stage can potentially identify tumours when intervention may improve treatment options and survival. Aim: To develop and validate an equation to predict absolute risk of prostate cancer in asymp... Read More about Predicting the risk of prostate cancer in asymptomatic men: a cohort study to develop and validate a novel algorithm.

Agreement and Disparities between Women and Stop-Smoking Specialists about How to Promote Adherence to Nicotine Replacement Therapy in Pregnancy (2021)
Journal Article
McDaid, L., Thomson, R., Emery, J., Coleman, T., Cooper, S., Phillips, L., & Naughton, F. (2021). Agreement and Disparities between Women and Stop-Smoking Specialists about How to Promote Adherence to Nicotine Replacement Therapy in Pregnancy. International Journal of Environmental Research and Public Health, 18(9), Article 4673. https://doi.org/10.3390/ijerph18094673

Evidence for the effectiveness of nicotine replacement therapy (NRT) for smoking-cessation in pregnancy is weak. This has been attributed to insufficient dosing and low adherence. This study investigated the acceptability of key messages and delivery... Read More about Agreement and Disparities between Women and Stop-Smoking Specialists about How to Promote Adherence to Nicotine Replacement Therapy in Pregnancy.

Randomised controlled trial of a Just-In-Time Adaptive Intervention (JITAI) smoking cessation smartphone app: The Quit Sense feasibility trial protocol (2021)
Journal Article
Naughton, F., Brown, C., High, J., Notley, C., Mascolo, C., Coleman, T., …Hope, A. (2021). Randomised controlled trial of a Just-In-Time Adaptive Intervention (JITAI) smoking cessation smartphone app: The Quit Sense feasibility trial protocol. BMJ Open, 11, Article e048204. https://doi.org/10.1136/bmjopen-2020-048204

Introduction A lapse (any smoking) early in a smoking cessation attempt is strongly associated with reduced success. A substantial proportion of lapses are due to urges to smoke triggered by situational cues. Currently no available interventions proa... Read More about Randomised controlled trial of a Just-In-Time Adaptive Intervention (JITAI) smoking cessation smartphone app: The Quit Sense feasibility trial protocol.

Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study (2021)
Journal Article
Zghebi, S. S., Mamas, M. A., Ashcroft, D. M., Rutter, M. K., Van Marwijk, H., Salisbury, C., …Kontopantelis, E. (2021). Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study. Open Heart, 8(1), Article e001498. https://doi.org/10.1136/openhrt-2020-001498

Objective: Most current cardiovascular disease (CVD) risk stratification tools are for people without CVD, but very few are for prevalent CVD. In this study, we developed and validated a CVD severity score in people with coronary heart disease (CHD)... Read More about Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study.

Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study (2021)
Journal Article
Blake, H., Knight, H., Jia, R., Corner, J., Morling, J. R., Denning, C., …Vedhara, K. (2021). Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study. International Journal of Environmental Research and Public Health, 18(8), Article 4182. https://doi.org/10.3390/ijerph18084182

We aimed to explore university students’ perceptions and experiences of SARS-CoV-2 mass asymptomatic testing, social distancing and self-isolation, during the COVID-19 pandemic. This qualitative study comprised of four rapid online focus groups condu... Read More about Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study.

Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK (2021)
Journal Article
Iyen, B., Weng, S., Vinogradova, Y., Akyea, R. K., Qureshi, N., & Kai, J. (2021). Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK. BMC Public Health, 21, Article 576. https://doi.org/10.1186/s12889-021-10606-1

Background: Although obesity is a well-recognised risk factor for cardiovascular disease (CVD), the impact of long-term body mass index (BMI) changes in overweight or obese adults, on the risk of heart failure, CVD and mortality has not been quantifi... Read More about Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK.

Systematic Identification of Familial Hypercholesterolaemia in Primary Care—A Systematic Review (2021)
Journal Article
Silva, L., Qureshi, N., Abdul-Hamid, H., Weng, S., Kai, J., & Leonardi-Bee, J. (2021). Systematic Identification of Familial Hypercholesterolaemia in Primary Care—A Systematic Review. Journal of Personalized Medicine, 11(4), Article 302. https://doi.org/10.3390/jpm11040302

Familial hypercholesterolaemia (FH) is a common inherited cause of premature cardiovascular disease, but the majority of patients remain undiagnosed. The aim of this systematic review was to assess the effectiveness of interventions to systematically... Read More about Systematic Identification of Familial Hypercholesterolaemia in Primary Care—A Systematic Review.

Helping Us Grow generations of GPs (HUGG): A pilot study evaluating Longitudinal Support Networks (LSNs) on recruitment, retention and resilience of GPs in Derbyshire (2021)
Journal Article
Imtiaz-Umer, S., Taggar, J., & Allsopp, G. (2021). Helping Us Grow generations of GPs (HUGG): A pilot study evaluating Longitudinal Support Networks (LSNs) on recruitment, retention and resilience of GPs in Derbyshire. Education for Primary Care, 32(3), 182-184. https://doi.org/10.1080/14739879.2021.1897955

Aim: To understand if longitudinal support networks (LSNs), including all career stages in General Practice (GP) from medical school to retirement, provide informal cross-generational support impacting on recruitment, retention and resilience of GPs... Read More about Helping Us Grow generations of GPs (HUGG): A pilot study evaluating Longitudinal Support Networks (LSNs) on recruitment, retention and resilience of GPs in Derbyshire.