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All Outputs (559)

Using the plan–do–study–act (PDSA) cycle to make change in general practice (2017)
Journal Article
Crowfoot, D., & Prasad, V. (in press). Using the plan–do–study–act (PDSA) cycle to make change in general practice. InnovAiT, https://doi.org/10.1177/1755738017704472

As new members of the team, GP trainees can provide a fresh perspective on practice systems. They are, therefore, ideally placed to enact change within practices. However, GP trainees may feel ill-equipped to suggest and deliver change to their pract... Read More about Using the plan–do–study–act (PDSA) cycle to make change in general practice.

Antipsychotic Prescribing to Patients Diagnosed with Dementia Without a Diagnosis of Psychosis in the Context of National Guidance and Drug Safety Warnings: Longitudinal Study in UK General Practice (2017)
Journal Article
Stocks, S. J., Kontopantelis, E., Webb, R. T., Avery, A. J., Burns, A., & Ashcroft, D. M. (2017). Antipsychotic Prescribing to Patients Diagnosed with Dementia Without a Diagnosis of Psychosis in the Context of National Guidance and Drug Safety Warnings: Longitudinal Study in UK General Practice. Drug Safety, 40(8), 679-692. https://doi.org/10.1007/s40264-017-0538-x

© 2017, The Author(s). Introduction: Policy interventions to address inappropriate prescribing of antipsychotic drugs to older people diagnosed with dementia are commonplace. In the UK, warnings were issued by the Medicines Healthcare products Regula... Read More about Antipsychotic Prescribing to Patients Diagnosed with Dementia Without a Diagnosis of Psychosis in the Context of National Guidance and Drug Safety Warnings: Longitudinal Study in UK General Practice.

A randomised controlled trial of a complex intervention to reduce children’s exposure to secondhand smoke in the home (2017)
Journal Article
Ratschen, E., Thorley, R., Jones, L. L., Opazo Breton, M., Cook, J., McNeill, A., …Lewis, S. (2018). A randomised controlled trial of a complex intervention to reduce children’s exposure to secondhand smoke in the home. Tobacco Control, 27(2), 155-162. https://doi.org/10.1136/tobaccocontrol-2016-053279

Objectives: Exposing children to secondhand tobacco smoke (SHS) causes significant harm and occurs predominantly through smoking by caregivers in the family home. We report a trial of a complex intervention designed to reduce secondhand smoke exposur... Read More about A randomised controlled trial of a complex intervention to reduce children’s exposure to secondhand smoke in the home.

Child injury prevention: a survey of local authorities and health boards (2017)
Journal Article
Chisholm, A., Watson, M. C., Jones, S. J., & Kendrick, D. (in press). Child injury prevention: a survey of local authorities and health boards. International Journal of Health Promotion and Education, 55(4), https://doi.org/10.1080/14635240.2017.1312479

Aims: Unintentional home injuries are a significant global public health issue and are a major cause of mortality and morbidity. Within each country, injuries disproportionately affect children from low income families. Recent guidance issued in the... Read More about Child injury prevention: a survey of local authorities and health boards.

Smoking cessation support by text message during pregnancy: a qualitative study of views and experiences of the MiQuit intervention (2017)
Journal Article
Sloan, M., Hopewell, S., Coleman, T., Cooper, S., & Naughton, F. (2017). Smoking cessation support by text message during pregnancy: a qualitative study of views and experiences of the MiQuit intervention. Nicotine and Tobacco Research, 19(5), https://doi.org/10.1093/ntr/ntw241

Introduction: SMS text messaging is increasingly used for delivering smoking cessation support and pilot studies suggest this may also be useful in pregnancy. This study explores the views of women who received a tailored text messaging cessation int... Read More about Smoking cessation support by text message during pregnancy: a qualitative study of views and experiences of the MiQuit intervention.

Sources of unsafe primary care for older adults: A mixed-methods analysis of patient safety incident reports (2017)
Journal Article
Cooper, A., Edwards, A., Williams, H., Evans, H. P., Avery, A., Hibbert, P., …Carson-Stevens, A. (2017). Sources of unsafe primary care for older adults: A mixed-methods analysis of patient safety incident reports. Age and Ageing, 46(5), 833-839. https://doi.org/10.1093/ageing/afx044

© The Author 2017. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. Background: older adults are frequent users of primary healthcare services, but are at increased risk of healthcare-related harm... Read More about Sources of unsafe primary care for older adults: A mixed-methods analysis of patient safety incident reports.

Autologous stem-cell transplantation in treatment-refractory Crohn's disease: an analysis of pooled data from the ASTIC trial (2017)
Journal Article
Lindsay, J. O., Clark, M., Allez, M., Labopin, M., Rogler, G., Rovira, M., …Ricart, E. (2017). Autologous stem-cell transplantation in treatment-refractory Crohn's disease: an analysis of pooled data from the ASTIC trial. Lancet Gastroenterology and Hepatology, 2(6), 399-406. https://doi.org/10.1016/S2468-1253%2817%2930056-0

Background: The randomised controlled ASTIC trial showed no benefit of mobilisation and autologous haematopoietic stem-cell transplantation (HSCT) compared with mobilisation followed by conventional therapy using a stringent primary endpoint (steroid... Read More about Autologous stem-cell transplantation in treatment-refractory Crohn's disease: an analysis of pooled data from the ASTIC trial.

Can machine-learning improve cardiovascular risk prediction using routine clinical data (2017)
Journal Article
Weng, S. F., Reps, J. M., Kai, J., Garibaldi, J. M., & Quereshi, N. (2017). Can machine-learning improve cardiovascular risk prediction using routine clinical data. PLoS ONE, 12(4), Article e0174944. https://doi.org/10.1371/journal.pone.0174944

Background Current approaches to predict cardiovascular risk fail to identify many people who would benefit from preventive treatment, while others receive unnecessary intervention. Machine-learning offers opportunity to improve accuracy by exploiti... Read More about Can machine-learning improve cardiovascular risk prediction using routine clinical data.

Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: cluster randomised controlled trial (2017)
Journal Article
Deave, T., Hawkins, A., Kumar, A., Hayes, M., Cooper, N., Watson, M., …Kendrick, D. (2017). Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: cluster randomised controlled trial. PLoS ONE, 12(3), Article e0172584. https://doi.org/10.1371/journal.pone.0172584

Background: Many developed countries have high mortality rates for fire-related deaths in children aged 0–14 years with steep social gradients. Evidence-based interventions to promote fire safety practices exist, but the impact of implementing a rang... Read More about Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: cluster randomised controlled trial.

Use of conspicuity aids by cyclists and risk of crashes involving other road users: population based case-control study (2017)
Journal Article
Miller, P., Kendrick, D., Coupland, C., & Coffey, F. (in press). Use of conspicuity aids by cyclists and risk of crashes involving other road users: population based case-control study. Journal of Transport and Health, 7(A), https://doi.org/10.1016/j.jth.2017.03.008

Background: Cycling can improve health and well-being by reducing inactivity. Concern about collision crashes may be a barrier to participation since collision crashes can lead to significant mortality and morbidity. The conspicuity of cyclists may b... Read More about Use of conspicuity aids by cyclists and risk of crashes involving other road users: population based case-control study.

Understanding the implementation and adoption of a technological intervention to improve medication safety in primary care: a realist evaluation (2017)
Journal Article
Jeffries, M., Phipps, D. L., Howard, R. L., Avery, A. J., Rodgers, S., & Ashcroft, D. M. (2017). Understanding the implementation and adoption of a technological intervention to improve medication safety in primary care: a realist evaluation. BMC Health Services Research, 17(1), https://doi.org/10.1186/s12913-017-2131-5

Background: Monitoring for potentially hazardous prescribing is increasingly important to improve medication safety. Healthcare information technology can be used to achieve this aim, for example by providing access to prescribing data through survei... Read More about Understanding the implementation and adoption of a technological intervention to improve medication safety in primary care: a realist evaluation.

Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS): study protocol for a randomized controlled trial (2017)
Journal Article
Sullivan, F., Farmer, E., Mair, F. S., Treweek, S., Kendrick, D., Jackson, C., …Schembri, S. (2017). Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS): study protocol for a randomized controlled trial. BMC Cancer, 17(1), https://doi.org/10.1186/s12885-017-3175-y

Background: Lung cancer is the most common cause of cancer related death worldwide. The majority of cases are detected at a late stage when prognosis is poor. The EarlyCDT®-Lung Test detects autoantibodies to abnormal cell surface proteins in the ear... Read More about Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS): study protocol for a randomized controlled trial.

Evolocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia: an evidence review group perspective of a NICE single technology appraisal (2017)
Journal Article
Carroll, C., Tappenden, P., Rafia, R., Hamilton, J., Chambers, D., Clowes, M., …Wierzbicki, A. S. (2017). Evolocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia: an evidence review group perspective of a NICE single technology appraisal. PharmacoEconomics, 35, 537-547. https://doi.org/10.1007/s40273-017-0492-6

As part of its single technology appraisal (STA) process, the UK National Institute for Health and Care Excellence (NICE) invited the manufacturer of evolocumab (Amgen) to submit evidence on the clinical and cost effectiveness of evolocumab. The appr... Read More about Evolocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia: an evidence review group perspective of a NICE single technology appraisal.

Promoting Healthy Adolescent Lifestyles Through Serious Games: Enacting a Multidisciplinary Approach (2017)
Book Chapter
Dunwell, I., Condon, L. A., Bul, K. C., Lang, A. R., Atkinson, S., Coulson, N. S., & Collins, E. (2017). Promoting Healthy Adolescent Lifestyles Through Serious Games: Enacting a Multidisciplinary Approach. In Serious Games and Edutainment Applications (323-348). Springer. https://doi.org/10.1007/978-3-319-51645-5_15

© Springer International Publishing AG 2017. Long-term health risks associated with unhealthy lifestyles present a significant current and future burden for healthcare providers. Adolescence represents a critical time for intervention, as habits form... Read More about Promoting Healthy Adolescent Lifestyles Through Serious Games: Enacting a Multidisciplinary Approach.

Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis (2017)
Journal Article
Little, I., Vinogradova, Y., Orton, E., Kai, J., & Qureshi, N. (2017). Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis. BMJ Open, 7(3), Article e012665. https://doi.org/10.1136/bmjopen-2016-012665

Objective: To determine whether sickle cell carriers (‘sickle cell trait’) have an increased risk of venous thromboembolism (VTE). Design: Cohort study with nested case-control analysis. Setting: General population with data from 609 UK gener... Read More about Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis.

Association between maternal depression and anxiety episodes and rates of childhood injuries: a cohort study from England (2017)
Journal Article
Baker, R., Kendrick, D., Tata, L. J., & Orton, E. (2017). Association between maternal depression and anxiety episodes and rates of childhood injuries: a cohort study from England. Injury Prevention, 23(6), 396-402. https://doi.org/10.1136/injuryprev-2016-042294

Background: Maternal depression is common and associated with several child health outcomes. The impact on childhood injuries is underexplored, with existing studies relying on maternal reporting of injury occurrences. Using population healthcare dat... Read More about Association between maternal depression and anxiety episodes and rates of childhood injuries: a cohort study from England.

Psychosocial interventions for supporting women to stop smoking in pregnancy (2017)
Journal Article
Chamberlain, C., O'Mara-Eves, A., Porter, J., Coleman, T., Perlen, S. M., Thomas, J., & McKenzie, J. E. (2017). Psychosocial interventions for supporting women to stop smoking in pregnancy. Cochrane Database of Systematic Reviews, Article CD001055. https://doi.org/10.1002/14651858.CD001055.pub5

Background: Tobacco smoking remains one of the few preventable factors associated with complications in pregnancy, and has serious long-term implications for women and babies. Smoking in pregnancy is decreasing in high-income countries, but is strong... Read More about Psychosocial interventions for supporting women to stop smoking in pregnancy.

Development, validity and reliability testing of the East Midlands Evaluation Tool (EMET) for measuring impacts on trainees’ confidence and competence following end of life care training (2017)
Journal Article
Whittaker, B., Parry, R., Bird, L., Watson, S., & Faull, C. (in press). Development, validity and reliability testing of the East Midlands Evaluation Tool (EMET) for measuring impacts on trainees’ confidence and competence following end of life care training. BMJ Supportive and Palliative Care, https://doi.org/10.1136/-2016001100

Objectives: To develop, test and validate a versatile questionnaire, the East Midlands Evaluation Tool (EMET), for measuring effects of end of life care training events on trainees’ self-reported confidence and competence. Methods: A paper-based q... Read More about Development, validity and reliability testing of the East Midlands Evaluation Tool (EMET) for measuring impacts on trainees’ confidence and competence following end of life care training.