All Outputs (787)

The interleukin-10 – 1082 G/A polymorphism: allele frequency in different populations and functional significance (2002)
Journal Article

Genotypic variation in the human interleukin-10 (IL-10) promoter may account for marked inter-individual variation in IL-10 production and may influence susceptibility to autoimmune diseases. The G/A polymorphism at position -1082 has been linked to... Read More about The interleukin-10 – 1082 G/A polymorphism: allele frequency in different populations and functional significance.

Comparision of the DNA binding properties of the E2 proteins from a high-risk and a low-risk HPV (2001)
Conference Proceeding

Combination of progesterone and mifepristone for cancer therapy (2001)
Other

Use of a steroid hormone or steroid hormone analogue and at least a portioUse of a steroid hormone or steroid hormone analogue and at least a portion of HPV E2 protein in the preparation of a pharmaceutical composition for the treatment of cervical c... Read More about Combination of progesterone and mifepristone for cancer therapy.

Human T-cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells (2001)
Journal Article

Persistent infection with human papillomavirus (HPV) type 16 has been implicated in the etiology of cervical cancer. The E2 protein is required early in viral infection and therefore may serve as a useful immune target for a vaccine aimed at preventi... Read More about Human T-cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells.

Contributions in the domain of cancer research: Review¶Human papillomaviruses and their role in cervical cancer (2001)
Journal Article

Human papillomaviruses (HPVs) have been linked to a variety of human diseases, most notably cancer of the cervix, a disease responsible for at least 200,000 deaths per year worldwide. Over 100 different types of HPV have been identified and these can... Read More about Contributions in the domain of cancer research: Review¶Human papillomaviruses and their role in cervical cancer.

Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins (2001)
Journal Article

Human papillomavirus (HPV) type 16 infects the genital tract and is generally acknowledged to be a causative agent of cervical cancer. HPV infection alone is not sufficient to induce cervical cancer and other factors such as steroid hormones are thou... Read More about Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins.

Pathological validation and significance of micrometastasis in sentinel nodes in primary breast cancer (2001)
Journal Article

In embracing a multidisciplinary approach to the management of patients with sentinel node biopsy in breast cancer, the pathologist task is to screen sentinel nodes for possible metastasis. The consequences of missing sentinel node micrometastasis ca... Read More about Pathological validation and significance of micrometastasis in sentinel nodes in primary breast cancer.

Investigation of human T cell responses to HPV16 E2 (2000)
Conference Proceeding

Methods of Inducing Cell Death (2000)
Other

The E2 proteins from high-risk and low-risk papillomaviruses differ in their ability to induce apoptotic cell death (2000)
Presentation / Conference

Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors (2000)
Journal Article

The human Surf-1 and Surf-2 genes are divergently transcribed and share a single bi-directional promoter. The addition of serum growth factors to serum-starved cells activates transcription in the Surf-1 direction, but has no effect on transcription... Read More about Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors.

The HPV 16 E2 protein induces p53-dependent apoptosis (2000)
Presentation / Conference

The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway (2000)
Journal Article

The human papillomavirus (HPV) E2 protein regulates viral gene expression and is also required for viral replication. HPV-transformed cells often contain chromosomally integrated copies of the HPV genome in which the viral E2 gene is disrupted. We ha... Read More about The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.

Magnesium ions enhance the transfer of Human Papillomavirus E2 protein from non-specific to specific binding sites (1999)
Journal Article

The human papillomavirus 16 E2 protein binds to four specific DNA sequences present within the HPV 16 genome and regulates viral gene expression and DNA replication. However, the E2 protein can also bind tightly to non-specific DNA sequences. Here, w... Read More about Magnesium ions enhance the transfer of Human Papillomavirus E2 protein from non-specific to specific binding sites.

Cellular transcirption factors regulate human papillomavirus type 16 gene expression by binding to a subset of the DNA sequences recognised by the viral E2 protein (1999)
Journal Article

Human papillomavirus type 16 (HPV-16) is a DNA tumour virus that has been implicated in the development of cervical cancer. The HPV-16 E2 protein binds to four sites that are present upstream of the viral P97 promoter and regulates transcription of t... Read More about Cellular transcirption factors regulate human papillomavirus type 16 gene expression by binding to a subset of the DNA sequences recognised by the viral E2 protein.

Disruption of the human papillomavirus type 16 E2 gene protects cervical carcinoma cells from E2F-induced apoptosis (1997)
Journal Article

Human papillomavirus type 16 (HPV-16) is a DNA tumour virus that has been implicated in the development of cervical cancer. In non-transformed HPV-infected cells, the HPV E2 protein regulates transcription of the viral E6 and E7 oncogenes. Malignant... Read More about Disruption of the human papillomavirus type 16 E2 gene protects cervical carcinoma cells from E2F-induced apoptosis.

A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors (1997)
Journal Article

The human Surf-1 and Surf-2 housekeeping genes are divergently transcribed and share a bi-directional, TATA-less promoter. Housekeeping promoters typically contain complex arrays of transcription factor binding sites and several studies have suggeste... Read More about A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors.

DNA binding and bending by the human papillomavirus type 16 E2 protein: recognition of an extended binding site (1997)
Journal Article

The human papillomavirus (HPV) 16 E2 protein (hE2) binds to four sites present upstream of the P97 promoter and regulates transcription of the viral E6 and E7 oncogenes. We have determined the relative binding constants for the interaction of the ful... Read More about DNA binding and bending by the human papillomavirus type 16 E2 protein: recognition of an extended binding site.

CpG methylation directly inhibits binding of the human papillomavirus type-16 E2 protein to specific DNA sequences (1996)
Journal Article

CpG methylation of the human papillomavirus upstream regulatory region has previously been shown to reduce virus promoter activity. Here, we demonstrate that methylation of the CpG dinucleotides contained within the binding site of the human papillom... Read More about CpG methylation directly inhibits binding of the human papillomavirus type-16 E2 protein to specific DNA sequences.

CpG methylation and the binding of YY1 and ETC proteins to the Surf-1/Surf-2 bidirectional promoter (1995)
Journal Article

The divergently transcribed Surf-1 and Surf-2 genes are separated by a bi-directional, TATA-less promoter which contains three important factor-binding sites, Sul, Su2 and Su3. The transcription initiation factor YY1 binds to the Sul site and stimula... Read More about CpG methylation and the binding of YY1 and ETC proteins to the Surf-1/Surf-2 bidirectional promoter.